Orvosi Hetilap
Volume/Issue:
Volume 151: Issue 51
Role of exhaled nitric oxide in predicting steroid response in chronic obstructive pulmonary disease
Author: Balázs Antus 1
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  • 1 Országos Korányi Tbc és Pulmonológiai Intézet Kórélettani Osztály Budapest Pihenő út 1. 1529
DOI:
https://doi.org/10.1556/oh.2010.28972
Page Count:
2083–2088
Publication Date:
01 Dec 2010
Online Publication Date:
08 Dec 2010
Article Category:
Research Article
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A kilégzett levegőben mérhető nitrogén-monoxid a legszélesebb körben vizsgált légúti biomarker. A stabil állapotú krónikus obstruktív tüdőbetegségben a kilégzett nitrogén-monoxid-szint hasonló vagy csak kismértékben emelkedett az egészségesekhez képest. Mivel a nitrogén-monoxid-szint szoros összefüggést mutat a légúti eosinophilia mértékével, és mivel az eosinophil típusú légúti gyulladás szteroidokra érzékenyebb, az emelkedett nitrogén-monoxid-szinttel rendelkező betegek jobb válaszkészséget mutatnak az inhalációs vagy szisztémás kortikoszteroidkezelésre. A krónikus obstruktív tüdőbetegség akut exacerbatiója során a kilégzett nitrogén-monoxid szintje megemelkedik, majd ennek kezelése után csökken. Mivel a nitrogén-monoxid-szint és a kezelés során elért légzésfunkciós javulás szoros korrelációt mutat egymással, a nitrogén-monoxid-méréssel a terápiás válasz megjósolható. Összefoglalva: a nitrogén-monoxid-méréssel a krónikus obstruktív tüdőbetegségben szenvedő betegek olyan alcsoportját lehet elkülöníteni, amelynek szteroidérzékenysége nagyobb. Orv. Hetil., 2010, 151, 2083–2088.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
COPD; légúti gyulladás; dohányzás; kilégzett NO; szteroid; válaszkészség; COPD; airway inflammation; smoking; exhaled nitric oxide; steroid; responsiveness

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