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  • 1 Vas Megyei Markusovszky Lajos Általános, Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktató Kórház Általános Belgyógyászati Osztály Szombathely
  • 2 Vas Megyei Markusovszky Lajos Általános, Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktató Kórház Központi Laboratórium Szombathely Markusovszky L. u. 5. 9700
  • 3 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest
  • 4 Pécsi Tudományegyetem, Egészségtudományi Kar Gyakorlati Diagnosztikai Tanszéki Csoport, Szombathelyi Képzési Központ Szombathely
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A differenciált pajzsmirigy-karcinómás betegek gondozásában a szérumtireoglobulin alapvető tumormarker. A tireoglobulin teljes hiányát nem lehet bizonyítani immunanalitikai módszerekkel, ha a beteg szérumában tireoglobulin ellen képződő autoantitest van jelen, ami differenciált pajzsmirigy-karcinómában szenvedő betegek közel 20%-ában előfordul. Ezért a szakmai ajánlások csak a tireoglobulin-autoantitest mennyiségének ismeretében javasolják a szérumtireoglobulin-lelet értékelését. A tireoglobulin-autoantitest normális szintje nem zárja ki a zavaró hatást, ugyanis nem ismert, hogy mekkora antitest-koncentrációnál nem kell antitest-interakcióval számolnunk. Ebben a tekintetben nem következetesek az irodalmi ajánlások, mivel ritkán tesznek különbséget a tireoglobulinautoantitest-negativitás és az alacsony, de még mérhető antitestszint között. Ezért nem egyértelmű, hogy az alacsony antitestszintek mennyire befolyásolják a tireoglobulin kimutathatóságát. A szerzők az irodalmi adatok és szakmai ajánlások tükrében tekintik át a szérumtireoglobulin- és tireoglobulinautoantitest-vizsgálat preanalitikai és analitikai korlátait, és saját eredményeik alapján javaslatot tesznek a tireoglobulinmeghatározás diagnosztikai pontosságának növelésére. Orv. Hetil., 2011, 152, 743–752.

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