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  • 1 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ I. Belgyógyászati Klinika Pécs Ifjúság u. 13. 7624
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A referátum a hepatitis C-vírus (HCV) patogenezisében érintett genetikai polimorfizmusokat tárgyalja, amelyek meghatározhatják a fertőzés kimenetelét. Ezen a téren korábban már a fő hisztokompatibilitási komplex alléleknek, másrészt különböző citokingén-variánsoknak a szerepét is vizsgálták. Újabban a teljesgenomtársulás-tanulmány és a célzott, egy nukleotidot érintő polimorfizmus (SNP) analízise révén az interleukin-28B (IL-28B) gén promoterrégiójában lokalizáltak egy olyan variánst, amely szoros kapcsolatot mutat a HCV eliminációjával és amely krónikus C hepatitisben a terápiás válasz legfontosabb kezelés előtti prediktorának bizonyult. Az elmúlt évben az inozin-trifoszfatáz (ITPA) hiányához vezető két génvariánsról pedig azt igazolták, hogy védőhatású a ribavirin okozta hemolitikus anaemiával szemben idült HCV-fertőzés antivirális kezelése alatt. Orv. Hetil., 2011, 152, 876–881.

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