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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar Pulmonológiai Klinika Budapest Diós árok 1/C 1125
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Közismert, hogy a területen szerzett pneumonia a súlyos szepszis és a korai halálozás leggyakoribb fertőzéses eredetű oka. A pneumoniával összefüggő mortalitás előre jelezhető az úgynevezett pneumoniasúlyossági indexszel és különféle biomarkerekkel (például prokalcitonin, troponin-I). A pneumococcusfertőzés ténye és a fertőzés súlyossága jellemezhető a vér pneumococcus-DNS-tartalmával. A pneumoniás betegek körében gyakori az akut myocardialis infarctussal kapcsolatos korai halálozás is. A pneumonián átesett betegek várható egyéves és öt-hat éves túlélése rosszabb, mint a megfelelően válogatott kontrollpopulációé. A pneumonia során megjelenő proinflammatorikus citokinek felerősítik az atheroscleroticus plakkokban egyébként is zajló gyulladásos folyamatokat, fokozzák az érbetegek eredendő prothromboticus hajlamát. Alighanem így magyarázható az az epidemiológiai megfigyelés, hogy a pneumonia a cardiovascularis halálozás önálló kockázati tényezője. Orv. Hetil., 2012, 153, 884–890.

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