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  • 1 Vas Megyei Markusovszky Kórház Non-profit Zrt., Egyetemi Oktatókórház Gasztroenterológiai és Belgyógyászati Osztály Szombathely Markusovszky u. 5. 9700
  • 2 Vas Megyei Markusovszky Kórház Non-profit Zrt., Egyetemi Oktatókórház Központi Laboratórium Szombathely
  • 3 Pécsi Tudományegyetem, Egészségügyi Kar Szombathelyi Képzési Központ Szombathely
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A nem szteroid gyulladásgátlók néhány eddigi tanulmányban eredményesnek tűntek a poszt-ERCP-s pancreatitis incidenciájának csökkentésében, de az eredmények további megerősítésre szorulnak. Célkitűzés: Rectalis indometacin hatásosságának megítélése az ERCP-t követő pancreatitis gyakoriságának csökkentésében. Módszer: Prospektív, randomizált, placebokontrollált tanulmány. Kétszázhuszonnyolc beteg ERCP előtt 10 perccel randomizáltan kapott 100 mg indometacint vagy placebokúpot. A pancreatitis értékelése a klinikai tünetek és a 24 órás szérumamilázszintek alapján történt. Eredmények: Sem a pancreatitis, sem a hyperamylasaemia gyakoriságában nem volt szignifikáns különbség a két vizsgálati csoport között, jóllehet, az indometacint kapottak közt jóval ritkábban fordult elő pancreatitis, különösen nők, 60 év felettiek és 25-nél kisebb BMI esetén. E tendencia egyáltalán nem érvényesült pancreasvezeték-töltés és pancreas-EST esetén. Következtetések: Az eredmények statisztikailag nem erősítik meg, hogy a rectalisan adott indometacin csökkenti a poszt-ERCP-s pancreatitis gyakoriságát, de az észlelt tendencia az indometacin preventív hatása mellett szólhat. Nagyobb esetszámú multicentrikus tanulmány szükséges az indometacin szerepének biztonságos megítéléséhez. Orv. Hetil., 2012, 153, 990–996.

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