Orvosi Hetilap
Volume/Issue:
Volume 153: Issue 43
Treatment of pretibial myxoedema with pentoxifylline
Authors: Boglárka Türke 1 and Csaba Balázs 2
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  • 1 Maros Megyei Klinikai Kórház Bőrgyógyászati Klinika Marosvásárhely
  • 2 Budai Irgalmasrendi Kórház Belgyógyászat Budapest Frankel Leo út 17–19. 1032
DOI:
https://doi.org/10.1556/oh.2012.29472
Page Count:
1719–1722
Publication Date:
01 Oct 2012
Online Publication Date:
22 Oct 2012
Article Category:
Research Article
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A praetibialis myxoedema a Basedow-kór ritkán előforduló tünete. Jóllehet, a betegség patomechanizmusa nem tisztázott, de a szövettani vizsgálatok a mukopoliszacharidok, glükózaminoglikánok felhalmozódását mutatták ki, és ebben a TSH-receptor elleni antitestek serkentő hatásának tulajdonítanak szerepet. Kezelési protokollja máig nem megoldott. A szerzők egy súlyos praetibialis myxoedemában szenvedő beteg pentoxifillinel történt sikeres kezeléséről számolnak be. A 34 éves férfi betegnél több autoimmun szervspecifikus kórkép (1-es típusú diabetes mellitus, Basedow–Graves-kór súlyos orbitopathiával) együttesen fordult elő. Az intézetbe kerülésekor észlelték súlyos praetibialis myxoedemás tüneteit, amelyet addig nem diagnosztizáltak és nem kezeltek. A betegség kezelését nehezítette, hogy a diabetes mellitus miatt szteroidot a kívánt dózisban nem kaphatott. A beteg intradermalis, parenteralis, majd orális pentoxifillinkezelésben részesült. A bőrtünetek fokozatosan regrediáltak. A kedvező terápiás effektus pontosan nem tisztázott, de a legvalószínűbb mechanizmus, hogy a pentoxifillin gátolja a citokinek felszabadulását, a fibroblastok proliferációját és a glükózaminoglikánok termelődését. A szerzők arra a következtetésre jutottak, hogy a pentoxifillin a praetibialis myxoedema kezelésére eredményesen és biztonságosan alkalmazható szteroid-ellenjavallat esetén. Orv. Hetil., 2012, 153, 1719–1722.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
praetibialis myxoedema; pentoxifillin; Basedow–Graves-kór; pretibial myxoedema; pentoxifylline; Graves’ disease

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