Orvosi Hetilap
Volume/Issue:
Volume 153: Issue 47
Clinical application of induced and spontaneous sputum in asthma and chronic obstructive pulmonary disease
Author: Balázs Antus 1
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  • 1 Országos Korányi Tbc- és Pulmonológiai Intézet Budapest Pihenő út 1. 1121
DOI:
https://doi.org/10.1556/oh.2012.29494
Page Count:
1847–1854
Publication Date:
01 Nov 2012
Online Publication Date:
18 Nov 2012
Article Category:
Research Article
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Az utóbbi évek kutatási eredményei alapján az indukált köpet vizsgálata a légúti gyulladás egyik noninvazív vizsgálómódszerévé vált az obstruktív tüdőbetegségekben. A köpetindukció biztonságos, a betegek által jól tolerált beavatkozás. A módszer metodikai standardizálása jelentősen növelte a köpetminták minőségét és a vizsgálatok reprodukálhatóságát. Klinikai szempontból a köpeteosinophilia kimutatásának van a legnagyobb jelentősége, mivel ez a betegek nagyobb szteroidérzékenységére utal. A köpet eozinofilsejt-számát is figyelembe vevő kezelési stratégia az asztmásokban az exacerbatiós ráta csökkenését eredményezi. A köpetfelülúszóban kimutatható gyulladásos mediátorok az asztma és a krónikus obstruktív tüdőbetegség patogenezisének pontosabb megismerését segítik elő. A spontán köpet sejtprofiljának meghatározása is értékes információt szolgáltat a gyulladásos folyamatokról a légutakban. A klinikai tanulmányok eredményei alapján a jövőben a köpet vizsgálata a klinikai gyakorlatban is elterjedhet. Orv. Hetil., 2012, 153, 1847–1854.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
asztma; indukció; légúti gyulladás; krónikus obstruktív tüdőbetegség; köpet; asthma; airway inflammation; induction; chronic obstructive pulmonary disease; sputum

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