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  • 1 Pécsi Tudományegyetem, Általános Orvostudományi Kar Igazságügyi Orvostani Intézet Pécs
  • | 2 Pécsi Tudományegyetem, Általános Orvostudományi Kar Bioanalitikai Intézet Pécs Szigeti út 12. 7624
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Bevezetés: A polyneuropathia számos perifériás ideg egyidejű megbetegedése, amelyet okozhatnak a daganatos betegek kezelésére alkalmazott gyógyszerek is. Ez azonban igen ritka, nem mindig bizonyítható szövődmény. Cél: A szerzők a neuropathiák vizsgálatára eddig nem használt módszert, a kalorimetria alkalmazását mutatják be állatkísérletes modellen. A vizsgálat gondolata egy 53 éves, daganatos betegségéből meggyógyult nőbeteg orvos szakértői véleményezése során merült fel; lehetett-e a betegnél kialakult polyneuropathia az alkalmazott cyclophosphamidkezelés következménye? Módszer: Vizsgálatuk során tengerimalacoknak intraperitonealisan cyclophosphamidot adtak az emberi terápiás dózissal arányos mennyiségben. A leölt állatokból eltávolított ideg- és izommintákon SETARAM Micro kaloriméterrel meghatározták a denaturációs hőmérsékletet. Eredmények: A minták termikus denaturációi az alkalmazott cyclophosphamiddózis függvényében csökkentek, a kalorimetriás entalpiái pedig emelkedtek. Az ideg nagyobb érzékenységet mutatott a kemoterápiás kezelésre, mint az izom. Következtetések: A cyclophosphamid hatására mind a perifériás idegekben, mind az izmokban kalorimetriával mérhető és igazolható termokémiai változások jöttek létre, amelyek mértéke az alkalmazott citosztatikum dózisától függött. Orv. Hetil., 2013, 154, 510–515.

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