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A szerző áttekinti az antibiotikumok és az antibiotikum-kutatás modern szemléletét, és összefoglalja a különféle – természetes, félszintetikus és szintetikus – antibiotikumoknak a kemoterápiában és más humánterápiás területeken betöltött jelenlegi szerepét. Vázolja az ismert és gyógyászatban alkalmazott antibiotikumok eredetét és más területeken (fiziológiás állapotok, mezőgazdaság) történő alkalmazásukat. Részletesen tárgyalja az elmúlt években felmerült problémákat, így a növekvő (poli)rezisztencia és virulencia témakörét és a nem tudományos, társadalmi, gazdasági, financiális kérdéseket. Röviden bemutatja a magyar antibiotikum-kutatás történetét. Ismerteti a jövőbeni kilátásokat és a természetes eredetű hatóanyagoknak a szintetikus szerekkel szembeni előnyeit. Új megközelítésekre hívja fel a figyelmet: a természet kimeríthetetlen élővilágában az új típusú, eddig nem vizsgált mikroorganizmusok és ezek bioszintetikus képességeinek jobb megismerését, valamint új biotechnológiai és genetikai módszerek (genomika, metagenomika, génbányászat) bevezetését. Orv. Hetil., 2013, 154, 563–573.

  • Bérdy, J.: Thoughts and facts about antibiotics: Where we are now and where we are heading. J. Antibiot. (Tokyo), 2012, 65, 385–395.

    Bérdy J. , 'Thoughts and facts about antibiotics: Where we are now and where we are heading ' (2012 ) 65 J. Antibiot. (Tokyo) : 385 -395.

    • Search Google Scholar
  • Bérdy, J.: Bioactive microbial metabolites. A Personal view. J. Antibiot. (Tokyo), 2005, 58, 1–26.

    Bérdy J. , 'Bioactive microbial metabolites. A Personal view ' (2005 ) 58 J. Antibiot. (Tokyo) : 1 -26.

    • Search Google Scholar
  • Demain, A. L., Sanchez, S.: Microbial drug discovry: 80 years of progress. J. Antibiot. (Tokyo), 2009, 62, 5–16.

    Sanchez S. , 'Microbial drug discovry: 80 years of progress ' (2009 ) 62 J. Antibiot. (Tokyo) : 5 -16.

    • Search Google Scholar
  • Donadio, S., Maffioli, S., Monciardini, P., et al.: Antibiotic discovery in the twenty-first century: current trends and future perspectives. J. Antibiot. (Tokyo), 2010, 63, 423–430.

    Monciardini P. , 'Antibiotic discovery in the twenty-first century: current trends and future perspectives ' (2010 ) 63 J. Antibiot. (Tokyo) : 423 -430.

    • Search Google Scholar
  • Monagham, R. L., Barrett, J. F.: Antibacterial drug discovery – then, now and the genomics future. Biochem. Pharmacol., 2006, 71, 901–909.

    Barrett J. F. , 'Antibacterial drug discovery – then, now and the genomics future ' (2006 ) 71 Biochem. Pharmacol. : 901 -909.

    • Search Google Scholar
  • Singh, S. B., Palaez, F.: Biodiversity, chemical diversity and drug discovery. Prog. Drug Res., 2008, 65, 143–174.

    Palaez F. , 'Biodiversity, chemical diversity and drug discovery ' (2008 ) 65 Prog. Drug Res. : 143 -174.

    • Search Google Scholar
  • Von Nussbaum, F., Brands, M., Hinzen, B., et al.: Antibacterial natural products in medicinal chemistry – Exodus or revival? Angew. Chem. Int. Ed. Engl., 2006, 45, 5072–5129.

    Hinzen B. , 'Antibacterial natural products in medicinal chemistry – Exodus or revival? ' (2006 ) 45 Angew. Chem. Int. Ed. Engl. : 5072 -5129.

    • Search Google Scholar
  • Paláez, F.: The historical delivery of antibiotics from microbial natural products – can history repeat? Biochem. Pharmacol., 2006, 71, 981–990.

    Paláez F. , 'The historical delivery of antibiotics from microbial natural products – can history repeat? ' (2006 ) 71 Biochem. Pharmacol. : 981 -990.

    • Search Google Scholar
  • Bérdy, J.: Handbook of Antibiotic Compounds. (Eds. Aszalos, A., Bostian, M., McNitt, K.) Vols. I to XIV/2. CRC Press, Boca Raton, 1980–1987.

    Bérdy J. , '', in Handbook of Antibiotic Compounds Vols. I to XIV/2. , (1980 ) -.

  • Bérdy, J.: Dictionary of Natural Products. CRC Press, London–Boca Raton, 1988–1994.

    Bérdy J. , '', in Dictionary of Natural Products , (1988 ) -.

  • Davies, J.: How to discover new antibiotics: harvesting the parvome. Curr. Opin. Chem. Biol., 2011, 15, 5–10.

    Davies J. , 'How to discover new antibiotics: harvesting the parvome ' (2011 ) 15 Curr. Opin. Chem. Biol. : 5 -10.

    • Search Google Scholar
  • Nicolaou, K. C., Chen, J. S., Edmonds, D. J., et al.: Recent advances in the chemistry and biology of naturally occurring antibiotics. Angew. Chem. Int. Ed. Engl., 2009, 48, 660–719.

    Edmonds D. J. , 'Recent advances in the chemistry and biology of naturally occurring antibiotics ' (2009 ) 48 Angew. Chem. Int. Ed. Engl. : 660 -719.

    • Search Google Scholar
  • Fernandes, P.: Antibacterial discovery and development – the failure of success? Nat. Biotechnol., 2006, 24, 1497–1503.

    Fernandes P. , 'Antibacterial discovery and development – the failure of success? ' (2006 ) 24 Nat. Biotechnol. : 1497 -1503.

    • Search Google Scholar
  • Crawford, J., Clardy, J.: Bacterial symbionts and natural products. Chem. Commun. (Camb.), 2011, 47, 7559–7566.

    Clardy J. , 'Bacterial symbionts and natural products ' (2011 ) 47 Chem. Commun. (Camb.) : 7559 -7566.

    • Search Google Scholar
  • Simmons, T. L., Coates, R. C., Clark, B. R., et al.: Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblaages. Proc. Natl. Acad. Sci. USA, 2008, 105, 4587–4594.

    Clark B. R. , 'Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblaages ' (2008 ) 105 Proc. Natl. Acad. Sci. USA : 4587 -4594.

    • Search Google Scholar
  • Imhoff, J. F., Labes, A., Wiese, J.: Bio-mining the microbial treasures of the ocean: new natural products. Biotechnol. Adv., 2011, 29, 468–482.

    Wiese J. , 'Bio-mining the microbial treasures of the ocean: new natural products ' (2011 ) 29 Biotechnol. Adv. : 468 -482.

    • Search Google Scholar
  • Harvey, A. L.: Natural products as a screening resource. Curr. Opin. Chem. Biol., 2007, 11, 480–484.

    Harvey A. L. , 'Natural products as a screening resource ' (2007 ) 11 Curr. Opin. Chem. Biol. : 480 -484.

    • Search Google Scholar
  • Linares, J. F., Gustafsson, I., Baquero, F., et al.: Antibiotics as intermicrobial signaling agents instead of weapons. Proc. Natl. Acad. Sci. USA, 2006, 103, 19484–19489.

    Baquero F. , 'Antibiotics as intermicrobial signaling agents instead of weapons ' (2006 ) 103 Proc. Natl. Acad. Sci. USA : 19484 -19489.

    • Search Google Scholar
  • Singh, B. K., Macdonald, C. A.: Drug discovery from uncultivable microorganisms. Drug Discov. Today, 2010, 15, 792–799.

    Macdonald C. A. , 'Drug discovery from uncultivable microorganisms ' (2010 ) 15 Drug Discov. Today : 792 -799.

    • Search Google Scholar
  • Vályi-Nagy, T., Úri, J., Szilágyi, I.: Primycin, a new antibiotic. Nature, 1954, 174, 1105–1106.

    Szilágyi I. , 'Primycin, a new antibiotic ' (1954 ) 174 Nature : 1105 -1106.

  • Yu, H., Zhang, L., Li, L., et al.: Recent developments and future prospects of antimicrobial metabolites produced by endophytes. Microbiol. Res., 2010, 165, 437–449.

    Li L. , 'Recent developments and future prospects of antimicrobial metabolites produced by endophytes ' (2010 ) 165 Microbiol. Res. : 437 -449.

    • Search Google Scholar
  • Kusari, S., Spiteller, M.: Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes? Nat. Prod. Rep., 2011, 28, 1203–1207.

    Spiteller M. , 'Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes? ' (2011 ) 28 Nat. Prod. Rep. : 1203 -1207.

    • Search Google Scholar
  • Rath, C. M., Janto, B., Earl, J., et al.: Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem. Biol., 2011, 6, 1244–1256.

    Earl J. , 'Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743 ' (2011 ) 6 ACS Chem. Biol. : 1244 -1256.

    • Search Google Scholar
  • Pickens, L. B., Tang, Y., Chooi, Y. H.: Metabolic engineering for the production of natural products. Annu. Rev. Chem. Biomol. Eng., 2011, 2, 211–236.

    Chooi Y. H. , 'Metabolic engineering for the production of natural products ' (2011 ) 2 Annu. Rev. Chem. Biomol. Eng. : 211 -236.

    • Search Google Scholar
  • Winter, J. M., Behnken, S., Hertweck, C.: Genomics-inspired discovery of natural products. Curr. Opin. Chem. Biol., 2011, 15, 22–31.

    Hertweck C. , 'Genomics-inspired discovery of natural products ' (2011 ) 15 Curr. Opin. Chem. Biol. : 22 -31.

    • Search Google Scholar
  • Knight, V., Sanglier, J-J., DiTullio, D., et al.: Diversifying microbial natural products for drug discovery. Appl. Microbiol. Biotechnol., 2003, 62, 446–458.

    DiTullio D. , 'Diversifying microbial natural products for drug discovery ' (2003 ) 62 Appl. Microbiol. Biotechnol. : 446 -458.

    • Search Google Scholar

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