Orvosi Hetilap
Volume/Issue:
Volume 154: Issue 17
Role of genetic and environmental factors in the development of polycystic ovary syndrome
Authors: László Ságodi, Emőke Kiss-Tóth 2 , and László Barkai
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  • 1 Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház Csecsemő- és Gyermekosztály Miskolc Szentpéteri kapu 72–76. 3524
  • 2 Miskolci Egyetem, Egészségügyi Kar Preventív Egészségtudományi Tanszék Miskolc
  • 3 Miskolci Egyetem Elméleti Egészségtudományi Tanszék Miskolc
  • 4 Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Gyermekegészségügyi Továbbképző Intézet Miskolc
DOI:
https://doi.org/10.1556/oh.2013.29589
Page Count:
650–657
Publication Date:
01 Apr 2013
Online Publication Date:
22 Apr 2013
Article Category:
Research Article
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A polycystás ovarium szindróma a leggyakoribb heterogén endokrin rendellenesség reproduktív korú nőkben. A szindróma továbbra is rejtélyes rendellenesség, amelynek etiológiája még nem tisztázott. Családi előfordulása viszonylag gyakori polycystás ovarium szindrómában szenvedő betegek körében, ami jelentős genetikai komponensre utal, jóllehet, az öröklődés módja nem tisztázott. A szerzők orvosi irodalmi adatok alapján áttekintették a genetikai és környezeti tényezők szerepét a polycystás ovarium szindróma kialakulásában. A mai napig még nem azonosítottak olyan gént, ami okozza vagy jelentős mértékben hozzájárul a kórkép fenotípusának kialakításához. A polycystás ovarium szindrómát olyan genetikai rendellenességnek kell tekinteni, amelyben számos genetikai és környezeti tényező kölcsönhatása határozza meg a heterogén klinikai és biokémiai fenotípust. Összefoglalva a jelenlegi bizonyítékokat, a szerzők arra a következtetésre jutottak, hogy a környezeti tényezők azonosítása és módosítása lehetségessé teszi azon személyek egészségének hatékonyabb védelmét, akiknél a genotípus vagy korábbi környezeti hatások hajlamosítanak a betegség kifejlődésére. Orv. Hetil., 2013, 154, 650–657.

  • Tfayli, H., Arslanian, S.: Menstrual health and the metabolic syndrome in adolescents. Ann. N. Y. Acad. Sci., 2008, 1135, 85–94.

    Arslanian S. , 'Menstrual health and the metabolic syndrome in adolescents ' (2008 ) 1135 Ann. N. Y. Acad. Sci. : 85 -94.

    • Search Google Scholar

  • Nicandri, K. F., Hoeger, K.: Diagnosis and treatment of polycystic ovarian syndrome in adolescents. Curr. Opin. Endocrinol. Diabetes Obes., 2012, 19, 497–504.

    Hoeger K. , 'Diagnosis and treatment of polycystic ovarian syndrome in adolescents ' (2012 ) 19 Curr. Opin. Endocrinol. Diabetes Obes. : 497 -504.

    • Search Google Scholar

  • Aggoun, Y.: Obesity, metabolic syndrome, and cardiovascular disease. Pediatr. Res., 2007, 61, 653–659.

    Aggoun Y. , 'Obesity, metabolic syndrome, and cardiovascular disease ' (2007 ) 61 Pediatr. Res. : 653 -659.

    • Search Google Scholar

  • Eriksson, J., Forsén, T., Osmond, C., et al.: Obesity from cradle to grave. Int. J. Obes. Relat. Metab. Disord., 2003, 27, 722–727.

    Osmond C. , 'Obesity from cradle to grave ' (2003 ) 27 Int. J. Obes. Relat. Metab. Disord. : 722 -727.

    • Search Google Scholar

  • Carmina, E.: PCOS: metabolic impact and long-term management. Minerva Ginecol., 2012, 64, 501–516.

    Carmina E. , 'PCOS: metabolic impact and long-term management ' (2012 ) 64 Minerva Ginecol. : 501 -516.

    • Search Google Scholar

  • Teede, H., Deeks, A., Moran, L.: Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med., 2010, 8, 41.

    Moran L. , 'Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan ' (2010 ) 8 BMC Med. : 41 -.

    • Search Google Scholar

  • Motta, A. B.: The role of obesity in the development of polycystic ovary syndrome. Curr. Pharm. Des., 2012, 18, 2482–2491.

    Motta A. B. , 'The role of obesity in the development of polycystic ovary syndrome ' (2012 ) 18 Curr. Pharm. Des. : 2482 -2491.

    • Search Google Scholar

  • Norman, R. J., Dewailly, D., Legro, R. S., et al.: Polycystic ovary syndrome. Lancet, 2007, 370, 685–697.

    Legro R. S. , 'Polycystic ovary syndrome ' (2007 ) 370 Lancet : 685 -697.

  • Sam, S., Legro, R. S., Essah, P., et al.: Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome. Proc. Natl. Acad. Sci. USA, 2006, 103, 7030–7035.

    Essah P. , 'Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome ' (2006 ) 103 Proc. Natl. Acad. Sci. USA : 7030 -7035.

    • Search Google Scholar

  • March, W. A., Moore, V. M., Willson, K. J., et al.: The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum. Reprod., 2010, 25, 544–551.

    Willson K. J. , 'The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria ' (2010 ) 25 Hum. Reprod. : 544 -551.

    • Search Google Scholar

  • Williams, R. M., Ong, K. K., Dunger, D. B.: Polycystic ovarian syndrome during puberty and adolescence. Mol. Cell. Endocrinol., 2013 Feb 4. pii: S0303-7207(13)00028-2 . doi: 10.1016/j.mce.2013.01.005 . [Epub ahead of print]

  • Legro, R. S., Strauss, J. F.: Molecular progress in infertility: polycystic ovary syndrome. Fertil Steril., 2002, 78, 569–576.

    Strauss J. F. , 'Molecular progress in infertility: polycystic ovary syndrome ' (2002 ) 78 Fertil Steril. : 569 -576.

    • Search Google Scholar

  • Diamanti-Kandarakis, E., Kandarakis, H., Legro, R. S.: The role of genes and environment in the etiology of PCOS. Endocrine, 2006, 30, 19–26.

    Legro R. S. , 'The role of genes and environment in the etiology of PCOS ' (2006 ) 30 Endocrine : 19 -26.

    • Search Google Scholar

  • Urbanek, M., Legro, R. S., Driscoll, D. A., et al.: Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc. Natl. Acad. Sci. USA, 1999, 96, 8573–8578.

    Driscoll D. A. , 'Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin ' (1999 ) 96 Proc. Natl. Acad. Sci. USA : 8573 -8578.

    • Search Google Scholar

  • Xita, N., Georgiou, I., Tsatsoulis, A.: The genetic basis of polycystic ovary syndrome. Eur. J. Endocrinol., 2002, 147, 717–725.

    Tsatsoulis A. , 'The genetic basis of polycystic ovary syndrome ' (2002 ) 147 Eur. J. Endocrinol. : 717 -725.

    • Search Google Scholar

  • Diamanti-Kandarakis, E., Papavassiliou, A. G.: Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol. Med., 2006, 12, 324–332.

    Papavassiliou A. G. , 'Molecular mechanisms of insulin resistance in polycystic ovary syndrome ' (2006 ) 12 Trends Mol. Med. : 324 -332.

    • Search Google Scholar

  • Daneshmand, S., Weitsman, S. R., Navab, A., et al.: Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promoters. Fertil. Steril., 2002, 77, 274–280.

    Navab A. , 'Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promoters ' (2002 ) 77 Fertil. Steril. : 274 -280.

    • Search Google Scholar

  • Strauss, J. F. 3rd.: Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome. Ann. N. Y. Acad. Sci., 2003, 997, 42–48.

    Strauss J. F. , 'Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome ' (2003 ) 997 Ann. N. Y. Acad. Sci. : 42 -48.

    • Search Google Scholar

  • Urbanek, M., Wu, X., Vickery, K. R., et al.: Allelic variants of the follistatin gene in polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 2000, 85, 4455–4461.

    Vickery K. R. , 'Allelic variants of the follistatin gene in polycystic ovary syndrome ' (2000 ) 85 J. Clin. Endocrinol. Metab. : 4455 -4461.

    • Search Google Scholar

  • Barker, D. J., Forsén, T., Uutela, A., et al.: Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study. BMJ, 2001, 323, 1273–1276.

    Uutela A. , 'Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study ' (2001 ) 323 BMJ : 1273 -1276.

    • Search Google Scholar

  • Singhal, A., Fewtrell, M., Cole, T. J., et al.: Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. Lancet, 2003, 361, 1089–1097.

    Cole T. J. , 'Low nutrient intake and early growth for later insulin resistance in adolescents born preterm ' (2003 ) 361 Lancet : 1089 -1097.

    • Search Google Scholar

  • Maciel, G. A., Baracat, E. C., Benda, J. A., et al.: Stockpiling of transitional and classic primary follicules in ovaries of women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 2004, 89, 5321–5327.

    Benda J. A. , 'Stockpiling of transitional and classic primary follicules in ovaries of women with polycystic ovary syndrome ' (2004 ) 89 J. Clin. Endocrinol. Metab. : 5321 -5327.

    • Search Google Scholar

  • Hogg, K., McNeilly, A. S., Duncan, W. C.: Prenatal androgen exposure leads to alterations in gene and protein expression in the ovine fetal ovary. Endocrinology, 2011, 152, 2048–2059.

    Duncan W. C. , 'Prenatal androgen exposure leads to alterations in gene and protein expression in the ovine fetal ovary ' (2011 ) 152 Endocrinology : 2048 -2059.

    • Search Google Scholar

  • Hogg, K., Young, J. M., Oliver, E. M., et al.: Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome. Endocrinology, 2012, 153, 450–461.

    Oliver E. M. , 'Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome ' (2012 ) 153 Endocrinology : 450 -461.

    • Search Google Scholar

  • Franasiak, J., Young, S. L., Williams, C. D., et al.: Longitudinal anti-müllerian hormone in women with polycystic ovary syndrome: an acupuncture randomized clinical trial. Evid Based Complement Alternat Med., 2012, 2012, 973712.

    Williams C. D. , 'Longitudinal anti-müllerian hormone in women with polycystic ovary syndrome: an acupuncture randomized clinical trial ' (2012 ) 2012 Evid Based Complement Alternat Med. : 973712 -.

    • Search Google Scholar

  • Károlyi, Z.: The pathomechanism of polycystic ovary syndrome in the light of recent research findings. [A polycystás ovarium szindróma kialakulásáról az újabb kutatások fényében.] Orv. Hetil., 2012, 153, 1567–1569. [Hungarian]

    Károlyi Z. , 'The pathomechanism of polycystic ovary syndrome in the light of recent research findings. [A polycystás ovarium szindróma kialakulásáról az újabb kutatások fényében.] ' (2012 ) 153 Orv. Hetil. : 1567 -1569.

    • Search Google Scholar

  • Franks, S., Webber, L. J., Goh, M., et al.: Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. J. Clin. Endocrinol. Metab., 2008, 93, 3396–3402.

    Goh M. , 'Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries ' (2008 ) 93 J. Clin. Endocrinol. Metab. : 3396 -3402.

    • Search Google Scholar

  • Holemans, K., Aerts, L., Van Assche, F. A.: Fetal growth restriction and consequences for the offspring in animal models. J. Soc. Gynecol. Investig., 2003, 10, 392–399.

    Assche F. A. , 'Fetal growth restriction and consequences for the offspring in animal models ' (2003 ) 10 J. Soc. Gynecol. Investig. : 392 -399.

    • Search Google Scholar

  • Heber, M. F., Vélez, L. M., Ferreira, S. R., et al.: The role of prenatal hyperandrogenism on lipid metabolism during adult life in a rat model. Medicina (B. Aires), 2012, 72, 389–392.

    Ferreira S. R. , 'The role of prenatal hyperandrogenism on lipid metabolism during adult life in a rat model ' (2012 ) 72 Medicina (B. Aires) : 389 -392.

    • Search Google Scholar

  • Davies, M. J., March, W. A., Willson, K. J., et al.: Birthweight and thinness at birth independently predict symptoms of polycystic ovary syndrome in adulthood. Hum. Reprod., 2012, 27, 1475–1480.

    Willson K. J. , 'Birthweight and thinness at birth independently predict symptoms of polycystic ovary syndrome in adulthood ' (2012 ) 27 Hum. Reprod. : 1475 -1480.

    • Search Google Scholar

  • Mumm, H., Kamper-Jørgensen, M., Nybo Andersen, A. M., et al.: Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991. Fertil. Steril., 2012 Nov 29. pii: S0015-0282(12)02398-9 .. doi: 10.1016/j.fertnstert.2012.11.004 . [Epub ahead of print]

  • Ilyés, I.: Insulin resistance in children born with weight and/or height low for gestational age. [A gesztációs idejükhöz viszonyítva kis súllyal és/vagy hosszal született gyerekek inzulinrezisztenciája.] Metabolizmus, 2012, 10, 157–159. [Hungarian]

    Ilyés I. , 'Insulin resistance in children born with weight and/or height low for gestational age. [A gesztációs idejükhöz viszonyítva kis súllyal és/vagy hosszal született gyerekek inzulinrezisztenciája.] ' (2012 ) 10 Metabolizmus : 157 -159.

    • Search Google Scholar

  • Sir-Petermann, T., Ladrón de Guevara, A., Villarroel, A. C., et al.: Polycystic ovary syndrome and pregnancy. Rev. Med. Chil., 2012, 140, 919–925.

    Villarroel A. C. , 'Polycystic ovary syndrome and pregnancy ' (2012 ) 140 Rev. Med. Chil. : 919 -925.

    • Search Google Scholar

  • Pasquali, R., Gambineri, A.: Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age. Ann. N. Y. Acad. Sci., 2006, 1092, 158–174.

    Gambineri A. , 'Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age ' (2006 ) 1092 Ann. N. Y. Acad. Sci. : 158 -174.

    • Search Google Scholar

  • Alvarez-Blasco, F., Botella-Carretero, J. I., San Millán, J. L., et al.: Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch. Intern. Med., 2006, 166, 2081–2086.

    Millán J. L. , 'Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women ' (2006 ) 166 Arch. Intern. Med. : 2081 -2086.

    • Search Google Scholar

  • Longo, S., Bollani, L., Decembrino, L., et al.: Short-term and long-term sequelae in intrauterine growth retardation (IUGR). J. Matern. Fetal Neonatal Med., 2013, 26, 222–225.

    Decembrino L. , 'Short-term and long-term sequelae in intrauterine growth retardation (IUGR) ' (2013 ) 26 J. Matern. Fetal Neonatal Med. : 222 -225.

    • Search Google Scholar

  • Melo, A. S., Vieira, C. S., Barbieri, M. A., et al.: High prevalence of polycystic ovary syndrome in women born small for gestational age. Hum. Reprod., 2010, 25, 2124–2131.

    Barbieri M. A. , 'High prevalence of polycystic ovary syndrome in women born small for gestational age ' (2010 ) 25 Hum. Reprod. : 2124 -2131.

    • Search Google Scholar

  • Mehrabian, F., Kelishadi, R.: Comparison of the metabolic parameters and androgen level of umbilical cord blood in newborns of mothers with polycystic ovary syndrome and controls. J. Res. Med. Sci., 2012, 17, 207–211.

    Kelishadi R. , 'Comparison of the metabolic parameters and androgen level of umbilical cord blood in newborns of mothers with polycystic ovary syndrome and controls ' (2012 ) 17 J. Res. Med. Sci. : 207 -211.

    • Search Google Scholar

  • Barker, D. J., Winter, P. D., Osmond, C., et al.: Weight in infancy and death from ischaemic heart disease. Lancet, 1989, 334, 577–580.

    Osmond C. , 'Weight in infancy and death from ischaemic heart disease ' (1989 ) 334 Lancet : 577 -580.

    • Search Google Scholar

  • Barker, D. J., Hales, C. N., Fall, C. H., et al.: Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia, 1993, 36, 62–67.

    Fall C. H. , 'Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth ' (1993 ) 36 Diabetologia : 62 -67.

    • Search Google Scholar

  • Dyer, J. S., Rosenfeld, C. R.: Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: a review. Semin. Reprod. Med., 2011, 29, 266–276.

    Rosenfeld C. R. , 'Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: a review ' (2011 ) 29 Semin. Reprod. Med. : 266 -276.

    • Search Google Scholar

  • Dover, G. J.: The Barker hypothesis: how pediatricans will diagnose and prevent common adult-onset diseases. Trans. Am. Clin. Climatol. Assoc., 2009, 120, 199–207.

    Dover G. J. , 'The Barker hypothesis: how pediatricans will diagnose and prevent common adult-onset diseases ' (2009 ) 120 Trans. Am. Clin. Climatol. Assoc. : 199 -207.

    • Search Google Scholar

  • Jaquet, D., Deghmoun, S., Chevenne, D., et al.: Dynamic change in adiposity from fetal to postnatal life is involved in the metabolic syndrome associated with reduced fetal growth. Diabetologia, 2005, 48, 849–855.

    Chevenne D. , 'Dynamic change in adiposity from fetal to postnatal life is involved in the metabolic syndrome associated with reduced fetal growth ' (2005 ) 48 Diabetologia : 849 -855.

    • Search Google Scholar

  • Forsén, T., Eriksson, J. G., Tuomilehto, J., et al.: Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ, 1997, 315, 837–840.

    Tuomilehto J. , 'Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study ' (1997 ) 315 BMJ : 837 -840.

    • Search Google Scholar

  • Hattersley, A. T., Tooke, J. E.: The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet, 1999, 353, 1789–1792.

    Tooke J. E. , 'The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease ' (1999 ) 353 Lancet : 1789 -1792.

    • Search Google Scholar

  • Gluckman, P. D., Pinal, C. S.: Regulation of fetal growth by the somatotrophic axis. J. Nutr., 2003, 133 (5 Suppl. 2), 1741S–1746S.

    Pinal C. S. , 'Regulation of fetal growth by the somatotrophic axis ' (2003 ) 133 J. Nutr. : 1741S -1746S.

    • Search Google Scholar

  • Vickers, M. H., Breier, B. H., McCarthy, D., et al.: Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2003, 285, R271–R273.

    McCarthy D. , 'Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition ' (2003 ) 285 Am. J. Physiol. Regul. Integr. Comp. Physiol. : R271 -R273.

    • Search Google Scholar

  • Hales, C. N., Barker, D. J.: The thrifty phenotype hypothesis. Br. Med. Bull., 2001, 60, 5–20.

    Barker D. J. , 'The thrifty phenotype hypothesis ' (2001 ) 60 Br. Med. Bull. : 5 -20.

  • Fall, C. H. D.: Childhood weight gain and the adiposity rebound. In: Brook, C. G. D. (ed.): Clinical pediatric endocrinology. Blackwell Publishing, 2006, 396–399.

    Fall C. H. D. , '', in Clinical pediatric endocrinology , (2006 ) -.

  • Reik, W., Constância, M., Fowden, A., et al.: Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J. Physiol., 2003, 547 (Pt 1), 35–44.

    Fowden A. , 'Regulation of supply and demand for maternal nutrients in mammals by imprinted genes ' (2003 ) 547 J. Physiol. : 35 -44.

    • Search Google Scholar

  • Lester, B. M., Tronick, E., Nestler, E., et al.: Behavioral epigenetics. Ann. N. Y. Acad. Sci., 2011, 1226, 14–33.

    Nestler E. , 'Behavioral epigenetics ' (2011 ) 1226 Ann. N. Y. Acad. Sci. : 14 -33.

  • Dumesic, D. A., Abbott, D. H., Padmanabhan, V.: Polycystic ovary syndrome and its developmental origins. Rev. Endocr. Metab. Disord., 2007, 8, 127–141.

    Padmanabhan V. , 'Polycystic ovary syndrome and its developmental origins ' (2007 ) 8 Rev. Endocr. Metab. Disord. : 127 -141.

    • Search Google Scholar

  • Poulsen, P., Vaag, A. A., Kyvik, K. O., et al.: Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia, 1997, 40, 439–446.

    Kyvik K. O. , 'Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs ' (1997 ) 40 Diabetologia : 439 -446.

    • Search Google Scholar

  • Phillips, D. I., Davies, M. J., Robinson, J. S.: Fetal growth and the fetal origins hypothesis in twins – problems and perspectives. Twin Res., 2001, 4, 327–331.

    Robinson J. S. , 'Fetal growth and the fetal origins hypothesis in twins – problems and perspectives ' (2001 ) 4 Twin Res. : 327 -331.

    • Search Google Scholar

  • Vink, J. M., Sadrzadeh, S., Lambalk, C. B., et al.: Heritability of polycystic ovary syndrome (PCOS) in a Dutch twin-family study. J. Clin. Endocrinol. Metab., 2006, 91, 2100–2104.

    Lambalk C. B. , 'Heritability of polycystic ovary syndrome (PCOS) in a Dutch twin-family study ' (2006 ) 91 J. Clin. Endocrinol. Metab. : 2100 -2104.

    • Search Google Scholar

  • Kosova, G., Urbanek, M.: Genetics of the polycystic ovary syndrome. Mol. Cell. Endocrinol., 2012 Oct 16. pii: S0303-7207(12)00461-3 .. doi: 10.1016/j.mce.2012.10.009 . [Epub ahead of print]

  • Urbanek, M.: The genetics of the polycystic ovary syndrome. Nat. Clin. Pract. Endocrinol. Metab., 2007, 3, 103–111.

    Urbanek M. , 'The genetics of the polycystic ovary syndrome ' (2007 ) 3 Nat. Clin. Pract. Endocrinol. Metab. : 103 -111.

    • Search Google Scholar

  • Franks, S., McCarthy, M.: Genetics of ovarian disorders: polycystic ovary syndrome. Rev. Endocr. Metab. Disord., 2004, 5, 69–76.

    McCarthy M. , 'Genetics of ovarian disorders: polycystic ovary syndrome ' (2004 ) 5 Rev. Endocr. Metab. Disord. : 69 -76.

    • Search Google Scholar

  • Franks, S., Berga, S. L.: Does PCOS have developmental origins? Fertil. Steril., 2012, 97, 2–6.

    Berga S. L. , 'Does PCOS have developmental origins? ' (2012 ) 97 Fertil. Steril. : 2 -6.

  • Demissie, M., Lazic, M., Foecking, E. M., et al.: Transient prenatal androgen exposure produces metabolic syndrome in adult female rats. Am. J. Physiol. Endocrinol. Metab., 2008, 295, E262–E268.

    Foecking E. M. , 'Transient prenatal androgen exposure produces metabolic syndrome in adult female rats ' (2008 ) 295 Am. J. Physiol. Endocrinol. Metab. : E262 -E268.

    • Search Google Scholar

  • Moran, L. J., Pasquali, R., Teede, H. J., et al.: Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil. Steril., 2009, 92, 1966–1982.

    Teede H. J. , 'Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society ' (2009 ) 92 Fertil. Steril. : 1966 -1982.

    • Search Google Scholar

  • Cole, B., Hensinger, K., Maciel, G. A., et al.: Human fetal ovary development involves the spatiotemporal expression of p450c17 protein. J. Clin. Endocrinol. Metab., 2006, 91, 3654–3661.

    Maciel G. A. , 'Human fetal ovary development involves the spatiotemporal expression of p450c17 protein ' (2006 ) 91 J. Clin. Endocrinol. Metab. : 3654 -3661.

    • Search Google Scholar

  • Fowler, P. A., Anderson, R. A., Saunders, P. T., et al.: Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary. J. Clin. Endocrinol. Metab., 2011, 96, 1754–1762.

    Saunders P. T. , 'Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary ' (2011 ) 96 J. Clin. Endocrinol. Metab. : 1754 -1762.

    • Search Google Scholar

  • Sir-Petermann, T., Codner, E., Pérez, V., et al.: Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 2009, 94, 1923–1930.

    Pérez V. , 'Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome ' (2009 ) 94 J. Clin. Endocrinol. Metab. : 1923 -1930.

    • Search Google Scholar

  • Geier, L. M., Bekx, M. T., Connor, E. L.: Factors contributing to initial weight loss among adolescents with polycystic ovary syndrome. J. Pediatr. Adolesc. Gynecol., 2012, 25, 367–370.

    Connor E. L. , 'Factors contributing to initial weight loss among adolescents with polycystic ovary syndrome ' (2012 ) 25 J. Pediatr. Adolesc. Gynecol. : 367 -370.

    • Search Google Scholar

  • Poomthavorn, P., Chaya, W., Mahachoklertwattana, P., et al.: Glucose metabolism in obese and lean adolescents with polycystic ovary syndrome.; J. Pediatr. Endocrinol. Metab., 2013 Jan 12, 1–6. doi: 10.1515/jpem-2012-0328 . [Epub ahead of print]

  • Barber, T. M., Franks, S.: Adipocyte biology in polycystic ovary syndrome. Mol. Cell. Endocrinol., 2012 Oct 17. pii: S0303-7207(12)00462-5 .. doi: 10.1016/j.mce.2012.10.010 . [Epub ahead of print]

  • Pinola, P., Lashen, H., Bloigu, A., et al.: Menstrual disorders in adolescence: a marker for hyperandrogenaemia and increased metabolic risks in later life? Finnish general population-based birth cohort study. Hum. Reprod., 2012, 27, 3279–3286.

    Bloigu A. , 'Menstrual disorders in adolescence: a marker for hyperandrogenaemia and increased metabolic risks in later life? Finnish general population-based birth cohort study ' (2012 ) 27 Hum. Reprod. : 3279 -3286.

    • Search Google Scholar

  • Li, L., Chen, X., He, Z., et al.: Clinical and metabolic features of polycystic ovary syndrome among Chinese adolescents. J. Pediatr. Adolesc. Gynecol., 2012, 25, 390–395.

    He Z. , 'Clinical and metabolic features of polycystic ovary syndrome among Chinese adolescents ' (2012 ) 25 J. Pediatr. Adolesc. Gynecol. : 390 -395.

    • Search Google Scholar

  • Markopoulos, M. C., Valsamakis, G., Kouskouni, E., et al.: Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause. Eur. J. Endocrinol., 2012, 168, 83–90.

    Kouskouni E. , 'Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause ' (2012 ) 168 Eur. J. Endocrinol. : 83 -90.

    • Search Google Scholar

  • Coviello, A. D., Legro, R. S., Dunaif, A.: Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J. Clin. Endocrinol. Metab., 2006, 91, 492–497.

    Dunaif A. , 'Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance ' (2006 ) 91 J. Clin. Endocrinol. Metab. : 492 -497.

    • Search Google Scholar

  • O’Meara, N. M., Blackman, J. D., Ehrmann, D. A., et al.: Defects in beta-cell function in functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab., 1993, 76, 1241–1247.

    Ehrmann D. A. , 'Defects in beta-cell function in functional ovarian hyperandrogenism ' (1993 ) 76 J. Clin. Endocrinol. Metab. : 1241 -1247.

    • Search Google Scholar

  • Dunaif, A., Segal, K. R., Futterweit, W., et al.: Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 1989, 38, 1165–1174.

    Futterweit W. , 'Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome ' (1989 ) 38 Diabetes : 1165 -1174.

    • Search Google Scholar

  • Robinson, S., Kiddy, D., Gelding, S. V., et al.: The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin. Endocrinol. (Oxf.), 1993, 39, 351–355.

    Gelding S. V. , 'The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries ' (1993 ) 39 Clin. Endocrinol. (Oxf.) : 351 -355.

    • Search Google Scholar

  • Jovanovic, V. P., Carmina, E., Lobo, R. A.: Not all women diagnosed with PCOS share the same cardiovascular risk profiles. Fertil. Steril., 2010, 94, 826–832.

    Lobo R. A. , 'Not all women diagnosed with PCOS share the same cardiovascular risk profiles ' (2010 ) 94 Fertil. Steril. : 826 -832.

    • Search Google Scholar

  • Marshall, J. C., Dunaif, A.: Should all women with PCOS be treated for insulin resistance? Fertil. Steril., 2012, 97, 18–22.

    Dunaif A. , 'Should all women with PCOS be treated for insulin resistance? ' (2012 ) 97 Fertil. Steril. : 18 -22.

    • Search Google Scholar

  • Okoroh, E. M., Hooper, W. C., Atrash, H. K., et al.: Prevalence of polycystic ovary syndrome among the privately insured, United States, 2003–2008. Am. J. Obstet. Gynecol., 2012, 207, 299, e1–e7.

    Atrash H. K. , 'Prevalence of polycystic ovary syndrome among the privately insured, United States, 2003–2008 ' (2012 ) 207 Am. J. Obstet. Gynecol. : 299, e1 -e7.

    • Search Google Scholar

  • Roe, A. H., Prochaska, E., Smith, M., et al.: Using the Androgen Excess-PCOS Society Criteria to diagnose polycystic ovary syndrome and the risk of metabolic syndrome in adolescents. J. Pediatr., 2012 Dec 19. pii: S0022-3476(12)01313-3 .. doi: 10.1016/j.jpeds.2012.11.019 . [Epub ahead of print]

  • Palmert, M. R., Gordon, C. M., Kartashov, A. I., et al.: Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 2002, 87, 1017–1023.

    Kartashov A. I. , 'Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome ' (2002 ) 87 J. Clin. Endocrinol. Metab. : 1017 -1023.

    • Search Google Scholar

  • Salley, K. E., Wickham, E. P., Cheang, K. I., et al.: Glucose intolerance in polycystic ovary syndrome – a position statement of the Androgen Excess Society. J. Clin. Endocrinol. Metab., 2007, 92, 4546–4556.

    Cheang K. I. , 'Glucose intolerance in polycystic ovary syndrome – a position statement of the Androgen Excess Society ' (2007 ) 92 J. Clin. Endocrinol. Metab. : 4546 -4556.

    • Search Google Scholar

  • Vilmann, L. S., Thisted, E., Baker, J. L., et al.: Development of obesity and polycystic ovary syndrome in adolescents. Horm. Res. Paediatr., 2012, 78, 269–278.

    Baker J. L. , 'Development of obesity and polycystic ovary syndrome in adolescents ' (2012 ) 78 Horm. Res. Paediatr. : 269 -278.

    • Search Google Scholar

  • Jakubowski, K. P., Black, J. J., El Nokali, N. E., et al.: Parents’ readiness to change affects BMI reduction outcomes in adolescents with polycystic ovary syndrome. J. Obes., 2012, 2012, 298067.

    Nokali N. E. , 'Parents’ readiness to change affects BMI reduction outcomes in adolescents with polycystic ovary syndrome ' (2012 ) 2012 J. Obes. : 298067 -.

    • Search Google Scholar

  • Wang, Y., Ge, K., Popkin, B. M.: Tracking of body mass index from childhood to adolescence: a 6-y follow-up study in China. Am. J. Clin. Nutr., 2000, 72, 1018–1024.

    Popkin B. M. , 'Tracking of body mass index from childhood to adolescence: a 6-y follow-up study in China ' (2000 ) 72 Am. J. Clin. Nutr. : 1018 -1024.

    • Search Google Scholar
Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
polycystás ovarium szindróma; genetikai tényezők; környezeti tényezők; polycystic ovarian syndrome; genetic factors; environmental factors

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