View More View Less
  • 1 Uzsoki Utcai Kórház Fővárosi Onkoradiológiai Központ Budapest Uzsoki u. 29. 1145
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

Közel másfél évtizede bizonyított a ciszplatinalapú radiokemoterápia előnye, mindenekelőtt az előrehaladott szolid tumorok kezelésében. Fej-nyaki és méhnyakdaganatokban már rendelkezésre állnak az áttekintő, sőt prospektív vizsgálatok eredményei. Bizonyítást nyert, hogy mind korai, mind előrehaladott stádiumban a lokális terápiás válasz és a teljes túlélés vonatkozásában jobb az egyedüli sugárterápiához képest. A ciszplatin hatása újabb hatékony molekulákkal (például m-TOR-gátlókkal, tirapazaminnal) valószínűleg tovább fokozható. Ismertetésre kerülnek ezeken túl a jelenleg folyó, a terápiás eredményeket hasonlóan tovább javító, nem ciszplatinalapú radiokemoterápiás kezelések is. Nem szabad megfeledkezni ugyanakkor arról, hogy mindenekelőtt a méhnyakrákok radiokemoterápiája – mint minden kombinált kezelés – együtt járhat hematológiai és/vagy hólyag- és bélkárosodással. Ennek megelőzésére és elkerülésére már saját tapasztalatok és nemzetközi ajánlások is rendelkezésre állnak. Orv. Hetil., 2013, 154, 803–809.

  • Mayer, A., Nemeskéri, Cs., Petneházi, C., et al.: Primary radiotherapy of stage IIA/B-IIIB cervical carcinoma. A comparison of continuous versus sequential regimens. Strahlenther. Onkol., 2004, 180, 209–215.

    Petneházi C. , 'Primary radiotherapy of stage IIA/B-IIIB cervical carcinoma. A comparison of continuous versus sequential regimens ' (2004 ) 180 Strahlenther. Onkol. : 209 -215.

    • Search Google Scholar
  • Keys, H. M., Bundy, B. N., Stehman, F. B., et al.: Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N. Engl. J. Med., 1999, 340, 1154–1161.

    Stehman F. B. , 'Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma ' (1999 ) 340 N. Engl. J. Med. : 1154 -1161.

    • Search Google Scholar
  • Whitney, C. W., Sause, W., Bundy, B. N., et al.: Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J. Clin. Oncol., 1999, 17, 1339–1348.

    Bundy B. N. , 'Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study ' (1999 ) 17 J. Clin. Oncol. : 1339 -1348.

    • Search Google Scholar
  • Morris, M., Eifel, P. J., Lu, J., et al.: Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N. Engl. J. Med., 1999, 340, 1137–1143.

    Lu J. , 'Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer ' (1999 ) 340 N. Engl. J. Med. : 1137 -1143.

    • Search Google Scholar
  • Rose, P. G., Bundy, B. N., Watkins, E. B., et al.: Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N. Engl. J. Med., 1999, 340, 1144–1153.

    Watkins E. B. , 'Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer ' (1999 ) 340 N. Engl. J. Med. : 1144 -1153.

    • Search Google Scholar
  • Peters, W. A. 3rd, Liu, P. Y., Barrett, R. J. 2nd, et al.: Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J. Clin. Oncol., 2000, 18, 1606–1613.

    Barrett R. J. , 'Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix ' (2000 ) 18 J. Clin. Oncol. : 1606 -1613.

    • Search Google Scholar
  • NCI Clinical Announcement: Concurrent Chemoradiation for Cervical Cancer. United States Department of Public Health, Washington, 1999.

    '', in Concurrent Chemoradiation for Cervical Cancer , (1999 ) -.

  • Green, J. A., Kirwan, J. M., Tierney, J. F., et al.: Survival and recurrence after concomitant chemotherapy, radiotherapy for cancer of the uterine cervix: a systematic review, meta-analysis. Lancet, 2001, 358, 781–786.

    Tierney J. F. , 'Survival and recurrence after concomitant chemotherapy, radiotherapy for cancer of the uterine cervix: a systematic review, meta-analysis ' (2001 ) 358 Lancet : 781 -786.

    • Search Google Scholar
  • Lukka, H., Hirte, H., Fyles, A., et al.: Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer – a metaanalysis. Clin. Oncol. (R. Coll. Radiol.), 2002, 14, 203–212.

    Fyles A. , 'Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer – a metaanalysis ' (2002 ) 14 Clin. Oncol. (R. Coll. Radiol.) : 203 -212.

    • Search Google Scholar
  • Novetsky, A. P., Einstein, M. H., Goldberg, G. L., et al.: Efficacy and toxicity of concomitant cisplatin with external beam pelvic radiotherapy and two high-dose-rate brachytherapy insertions for the treatment of locally advanced cervical cancer. Gynecol. Oncol., 2007, 105, 635–640.

    Goldberg G. L. , 'Efficacy and toxicity of concomitant cisplatin with external beam pelvic radiotherapy and two high-dose-rate brachytherapy insertions for the treatment of locally advanced cervical cancer ' (2007 ) 105 Gynecol. Oncol. : 635 -640.

    • Search Google Scholar
  • Pearcey, R., Brundage, M., Drouin, P., et al.: Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J. Clin. Oncol., 2002, 20, 966–972.

    Drouin P. , 'Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix ' (2002 ) 20 J. Clin. Oncol. : 966 -972.

    • Search Google Scholar
  • Tseng, C. J., Chang, C. T., Lai, C. H., et al.: A randomized trial of concurrent chemoradiotherapy versus radiotherapy in advanced carcinoma of the uterine cervix. Gynecol. Oncol., 1997, 66, 52–58.

    Lai C. H. , 'A randomized trial of concurrent chemoradiotherapy versus radiotherapy in advanced carcinoma of the uterine cervix ' (1997 ) 66 Gynecol. Oncol. : 52 -58.

    • Search Google Scholar
  • Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC): Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis. Cochrane Database Syst. Rev., 2010 Jan 20, CD008285.

  • Eifel, P. J., Winter, K., Morris, M., et al.: Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of Radiation Therapy Oncology Group trial (RTOG) 90-01. J. Clin. Oncol., 2004, 22, 872–880.

    Morris M. , 'Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of Radiation Therapy Oncology Group trial (RTOG) 90-01 ' (2004 ) 22 J. Clin. Oncol. : 872 -880.

    • Search Google Scholar
  • Kim, Y. S., Shin, S. S., Nam, J. H., et al.: Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer. Gynecol. Oncol., 2008, 108, 195–200.

    Nam J. H. , 'Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer ' (2008 ) 108 Gynecol. Oncol. : 195 -200.

    • Search Google Scholar
  • Einstein, M. H., Novetsky, A. P., Garg, M., et al.: Survival and toxicity differences between 5-day and weekly cisplatin in patients with locally advanced cervical cancer. Cancer, 2007, 109, 48–53.

    Garg M. , 'Survival and toxicity differences between 5-day and weekly cisplatin in patients with locally advanced cervical cancer ' (2007 ) 109 Cancer : 48 -53.

    • Search Google Scholar
  • Kunos, C., Tian, C., Waggoner, S., et al.: Retrospective analysis of concomitant cisplatin during radiation in patients aged 55 years or older for treatment of advanced cervical cancer: a Gynecologic Oncology Group study. Int. J. Gynecol. Cancer, 2009, 19, 1258–1263.

    Waggoner S. , 'Retrospective analysis of concomitant cisplatin during radiation in patients aged 55 years or older for treatment of advanced cervical cancer: a Gynecologic Oncology Group study ' (2009 ) 19 Int. J. Gynecol. Cancer : 1258 -1263.

    • Search Google Scholar
  • Atahan, I. L., Onal, C., Ozyar, E., et al.: Long-term outcome and prognostic factors in patients with cervical carcinoma: a retrospective study. Int. J. Gynecol. Cancer, 2007, 17, 833–842.

    Ozyar E. , 'Long-term outcome and prognostic factors in patients with cervical carcinoma: a retrospective study ' (2007 ) 17 Int. J. Gynecol. Cancer : 833 -842.

    • Search Google Scholar
  • Parker, K., Gallop-Evans, E., Hanna, L., et al.: Five years’ experience treating locally advanced cervical cancer with concurrent chemoradiotherapy and high-dose-rate brachytherapy: results from a single institution. Int. J. Radiat. Oncol. Biol. Phys., 2009, 74, 140–146.

    Hanna L. , 'Five years’ experience treating locally advanced cervical cancer with concurrent chemoradiotherapy and high-dose-rate brachytherapy: results from a single institution ' (2009 ) 74 Int. J. Radiat. Oncol. Biol. Phys. : 140 -146.

    • Search Google Scholar
  • Lanciano, R., Calkins, A., Bundy, B. N., et al.: Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination with pelvic radiation in advanced cervix cancer: a Gynecologic Oncology Group study. J. Clin. Oncol., 2005, 23, 8289–8295.

    Bundy B. N. , 'Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination with pelvic radiation in advanced cervix cancer: a Gynecologic Oncology Group study ' (2005 ) 23 J. Clin. Oncol. : 8289 -8295.

    • Search Google Scholar
  • Dueñas-González, A., Zarbá, J. J., Patel, F., et al.: A phase III open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J. Clin. Oncol., 2011, 29, 1678–1685.

    Patel F. , 'A phase III open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix ' (2011 ) 29 J. Clin. Oncol. : 1678 -1685.

    • Search Google Scholar
  • Gatcliffe, T. A., Tewari, K. S., Shah, A., et al.: A feasibility study of topotecan with standard-dose cisplatin and concurrent primary radiation therapy in locally advanced cervical cancer. Gynecol. Oncol., 2009, 112, 85–89.

    Shah A. , 'A feasibility study of topotecan with standard-dose cisplatin and concurrent primary radiation therapy in locally advanced cervical cancer ' (2009 ) 112 Gynecol. Oncol. : 85 -89.

    • Search Google Scholar
  • Rao, G. G., Rogers, P., Drake, R. D., et al.: Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer. Gynecol. Oncol., 2005, 96, 168–172.

    Drake R. D. , 'Phase I clinical trial of weekly paclitaxel, weekly carboplatin, and concurrent radiotherapy for primary cervical cancer ' (2005 ) 96 Gynecol. Oncol. : 168 -172.

    • Search Google Scholar
  • Lee, C. M., Shrieve, D. C., Zempolich, K. A., et al.: Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix. Gynecol. Oncol., 2005, 99, 415–421.

    Zempolich K. A. , 'Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix ' (2005 ) 99 Gynecol. Oncol. : 415 -421.

    • Search Google Scholar
  • Lee, C. M., Lee, R. J., Hammond, E., et al.: Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis. Gynecol. Oncol., 2004, 93, 209–214.

    Hammond E. , 'Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis ' (2004 ) 93 Gynecol. Oncol. : 209 -214.

    • Search Google Scholar
  • Moore, K. N., Sill, M. W., Miller, D. S., et al.: A phase I trial of tailored radiation therapy with concomitant cetuximab and cisplatin in the treatment of patients with cervical cancer: A gynecologic oncology group study. Gynecol. Oncol., 2012, 127, 456–461.

    Miller D. S. , 'A phase I trial of tailored radiation therapy with concomitant cetuximab and cisplatin in the treatment of patients with cervical cancer: A gynecologic oncology group study ' (2012 ) 127 Gynecol. Oncol. : 456 -461.

    • Search Google Scholar
  • Schilder, R. J., Sill, M. W., Lee, Y. C., et al.: A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study. Int. J. Gynecol. Cancer, 2009, 19, 929–933.

    Lee Y. C. , 'A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study ' (2009 ) 19 Int. J. Gynecol. Cancer : 929 -933.

    • Search Google Scholar
  • Mackay, H. J., Tinker, A., Winquist, E., et al.: A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184. Gynecol. Oncol., 2010, 116, 163–167.

    Winquist E. , 'A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184 ' (2010 ) 116 Gynecol. Oncol. : 163 -167.

    • Search Google Scholar
  • Temkin, S. M., Yamada, S. D., Fleming, G. F.: A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol. Oncol., 2010, 117, 473–476.

    Fleming G. F. , 'A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies ' (2010 ) 117 Gynecol. Oncol. : 473 -476.

    • Search Google Scholar
  • Rischin, D., Peters, L., Fisher, R., et al.: Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J. Clin. Oncol., 2005, 23, 79–87.

    Fisher R. , 'Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02) ' (2005 ) 23 J. Clin. Oncol. : 79 -87.

    • Search Google Scholar
  • Rischin, D., Narayan, K., Oza, A. M., et al.: Phase 1 study of tirapazamine in combination with radiation and weekly cisplatin in patients with locally advanced cervical cancer. Int. J. Gynecol. Cancer, 2010, 20, 827–833.

    Oza A. M. , 'Phase 1 study of tirapazamine in combination with radiation and weekly cisplatin in patients with locally advanced cervical cancer ' (2010 ) 20 Int. J. Gynecol. Cancer : 827 -833.

    • Search Google Scholar
  • Folkman, J.: What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 1990, 82, 4–6.

    Folkman J. , 'What is the evidence that tumors are angiogenesis dependent? ' (1990 ) 82 J. Natl. Cancer Inst. : 4 -6.

    • Search Google Scholar
  • Komaki, R., Brickner, T. J., Hanlon, A. L., et al.: Long-term results of treatment of cervical carcinoma in the United States in 1973, 1978, and 1983: Patterns of Care Study (PCS). Int. J. Radiat. Oncol. Biol. Phys., 1995, 31, 973–982.

    Hanlon A. L. , 'Long-term results of treatment of cervical carcinoma in the United States in 1973, 1978, and 1983: Patterns of Care Study (PCS) ' (1995 ) 31 Int. J. Radiat. Oncol. Biol. Phys. : 973 -982.

    • Search Google Scholar
  • Logsdon, M. D., Eifel, P. J.: Figo IIIB squamous cell carcinoma of the cervix: an analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 1999, 43, 763–775.

    Eifel P. J. , 'Figo IIIB squamous cell carcinoma of the cervix: an analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy ' (1999 ) 43 Int. J. Radiat. Oncol. Biol. Phys. : 763 -775.

    • Search Google Scholar
  • Eifel, P. J., Moughan, J., Owen, J., et al.: Patterns of radiotherapy practice for patients with squamous carcinoma of the uterine cervix: patterns of care study. Int. J. Radiat. Oncol. Biol. Phys., 1999, 43, 351–358.

    Owen J. , 'Patterns of radiotherapy practice for patients with squamous carcinoma of the uterine cervix: patterns of care study ' (1999 ) 43 Int. J. Radiat. Oncol. Biol. Phys. : 351 -358.

    • Search Google Scholar
  • Kirisits, C., Pötter, R., Lang, S., et al.: Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer. Int. J. Radiat. Oncol. Biol. Phys., 2005, 62, 901–911.

    Lang S. , 'Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer ' (2005 ) 62 Int. J. Radiat. Oncol. Biol. Phys. : 901 -911.

    • Search Google Scholar
  • Hoskin, P. J., Bownes, P.: Innovative technologies in radiation therapy: Brachytherapy. Semin. Radiat. Oncol., 2006, 16, 209–217.

    Bownes P. , 'Innovative technologies in radiation therapy: Brachytherapy ' (2006 ) 16 Semin. Radiat. Oncol. : 209 -217.

    • Search Google Scholar
  • Nag, S.: Controversies and new developments in gynecologic brachytherapy: Image-based intracavitary brachytherapy for cervical carcinoma. Semin. Radiat. Oncol., 2006, 16, 164–167.

    Nag S. , 'Controversies and new developments in gynecologic brachytherapy: Image-based intracavitary brachytherapy for cervical carcinoma ' (2006 ) 16 Semin. Radiat. Oncol. : 164 -167.

    • Search Google Scholar
  • Pötter, R., Dimopoulos, J., Bachtiary, B., et al.: 3D conformal HDR-brachy- and external beam therapy plus simultaneous cisplatin for high-risk cervical cancer: clinical experience with 3 year follow-up. Radiother. Oncol., 2006, 79, 80–86.

    Bachtiary B. , '3D conformal HDR-brachy- and external beam therapy plus simultaneous cisplatin for high-risk cervical cancer: clinical experience with 3 year follow-up ' (2006 ) 79 Radiother. Oncol. : 80 -86.

    • Search Google Scholar
  • Klopp, A. H., Eifel, P. J.: Chemoradiotherapy for cervical cancer in 2010. Curr. Oncol. Rep., 2011, 13, 77–85.

    Eifel P. J. , 'Chemoradiotherapy for cervical cancer in 2010 ' (2011 ) 13 Curr. Oncol. Rep. : 77 -85.

    • Search Google Scholar
  • Póti, Zs., Patyánik, M., Nemeskéri, C.: Radiochemotherapy of cervical carcinoma (Necessity of dose reduction in chemotherapy). [Méhnyakrák radiokemoterápiája (kemoterápiás dózisredukció szükségessége).] Orv. Hetil., 2006, 147, 1315–1320. [Hungarian]

    Nemeskéri C. , 'Radiochemotherapy of cervical carcinoma (Necessity of dose reduction in chemotherapy). [Méhnyakrák radiokemoterápiája (kemoterápiás dózisredukció szükségessége).] ' (2006 ) 147 Orv. Hetil. : 1315 -1320.

    • Search Google Scholar
  • Patyánik, M., Nemeskéri, C., Póti, Z., et al.: Concomitant radiochemotherapy of cervical cancer: is it justified to reduce the dosage of cisplatin? Strahlenther. Onkol., 2009, 185, 582–587.

    Póti Z. , 'Concomitant radiochemotherapy of cervical cancer: is it justified to reduce the dosage of cisplatin? ' (2009 ) 185 Strahlenther. Onkol. : 582 -587.

    • Search Google Scholar
  • Song, S., Rudra, S., Hasselle, M. D., et al.: The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy. Cancer, 2013, 119, 325–331.

    Hasselle M. D. , 'The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy ' (2013 ) 119 Cancer : 325 -331.

    • Search Google Scholar
  • Henke, M., Laszig, R., Rübe, C., et al.: Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet, 2003, 362, 1255–1260.

    Rübe C. , 'Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial ' (2003 ) 362 Lancet : 1255 -1260.

    • Search Google Scholar