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  • 1 Állami Népegészségügyi és Tisztiorvosi Szolgálat Dél-dunántúli Regionális Intézete Regionális Virológiai Laboratórium, Gastroenteralis Vírusok Nemzeti Referencialaboratóriuma Pécs Szabadság u. 7. 7623
  • | 2 Pécsi Tudományegyetem, Általános Orvostudományi Kar Bőr-, Nemikórtani és Onkodermatológiai Klinika Pécs
  • | 3 Pécsi Tudományegyetem, Általános Orvostudományi Kar Patológiai Intézet, 2. Diagnosztikus Laboratórium Pécs
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Az emberi daganatok mintegy 20%-ában bizonyítható valamilyen fertőző virális ágens kóroki szerepe. A Merkel-sejtes carcinoma ritka, igen agresszív, bizonytalan eredetű, vélhetően a hám stratum basale rétegéből kiinduló daganat. Elsősorban az időseket és az immunszuppresszált személyeket érinti, többnyire a napfénynek kitett bőrterületeken, különösen a fej-nyaki régiókon jelentkezik. Gyakorisága rohamosan növekszik, nemritkán differenciáldiagnosztikai problémát okoz. A Merkel-sejtes carcinomákból 2008-ban egy DNS-polyomavírust (Merkel-sejtes polyomavírus) sikerült azonosítani, amely megnyitotta az utat a daganat valódi kóroki hátterének feltárásához. Az elváltozás fertőző – virális – kóreredete szemléletváltást eredményez a patogenezis és remélhetőleg majd a kezelés területén is. Az ismeretek hazai klinikai gyakorlatba való mielőbbi átkerülése érdekében vállalkoztak a szerzők a Merkel-sejtes carcinoma és az első emberi daganatkeltő polyomavírus, a Merkel-sejtes polyomavírus összefoglalására. Orv. Hetil., 2013, 154, 102–112.

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