A cardiovascularis halálozás csökkentésében nagy szerepet játszanak a statinok, amelyek mind a primer, mind a szekunder prevencióban hatásosak. Az utóbbi években merült fel, hogy diabetogén hatással is rendelkezhetnek, mivel a megfigyelések szerint kisfokban növelhetik az újonnan kialakult diabetes mellitus kockázatát. A statinok e hatása csoporthatás, de dózisfüggő is. Mindenesetre a statinok cardiovascularis kockázatot csökkentő hatása többszörösen ellensúlyozza az esetleg kialakuló diabetes miatt jelentkező többletkockázatot, ezért első vonalbeli szerként adandók az LDL-koleszterin-célértékek elérésére. Orv. Hetil., 2013, 154, 1691–1695.
Baigent, C., Keech, A., Kearney, P. M., et al., Cholesterol Treatment Trialists’ (CTT) Collaborators: Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet, 2005, 366, 1267–1278.
Kearney P. M. , 'Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins ' (2005 ) 366 Lancet : 1267 -1278 .
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., et al.: Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation, 2004, 110, 227–239.
Merz C. N. B. , 'Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines ' (2004 ) 110 Circulation : 227 -239 .
Sarwar, N., Gao, P., Seshasai, S. R., et al.: Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet, 2010, 375, 2215–2222.
Seshasai S. R. , 'Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies ' (2010 ) 375 Lancet : 2215 -2222 .
Stamler, J., Vaccaro, O., Neaton, J. D., et al., for the Multiple Risk Factor Intervention Trial Research Group: Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care, 1993, 16, 434–444.
Neaton J. D. , 'Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial ' (1993 ) 16 Diabetes Care : 434 -444 .
Chen, Z., Peto, R., Collins, R., et al.: Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ, 1991, 303, 276–282.
Collins R. , 'Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations ' (1991 ) 303 BMJ : 276 -282 .
Waters, D. D., Guyton, J. R., Herrington, D. M., et al., TNT Steering Committee Members and Investigators: Treating to New Targets (TNT) Study: does lowering low-density lipoprotein cholesterol levels below currently recommended guidelines yield incremental clinical benefit? Am. J. Cardiol., 2004, 93, 154–158.
Herrington D. M. , 'Treating to New Targets (TNT) Study: does lowering low-density lipoprotein cholesterol levels below currently recommended guidelines yield incremental clinical benefit? ' (2004 ) 93 Am. J. Cardiol. : 154 -158 .
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., et al., REVERSAL Investigators: Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA, 2004, 291, 1071–1080.
Schoenhagen P. , 'Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial ' (2004 ) 291 JAMA : 1071 -1080 .
Nissen, S. E., Nicholls, S. J., Sipahi, I., et al., ASTEROID Investigators: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA, 2006, 295, 1556–1565.
Sipahi I. , 'Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial ' (2006 ) 295 JAMA : 1556 -1565 .
Nicholls, S. J., Ballantyne, C. M., Barter, P. J., et al.: Effect of two intensive statin regimens on progression of coronary disease. N. Engl. J. Med., 2011, 365, 2078–2087.
Barter P. J. , 'Effect of two intensive statin regimens on progression of coronary disease ' (2011 ) 365 N. Engl. J. Med. : 2078 -2087 .
Szollár, L., Pados, Gy., Balogh, S., et al.: Recommendations of the 5th Hungarian Cardiovascular Consensus Conference. [Összefoglalás az V. Magyar Kardiovaszkuláris Konszenzus Konferencia ajánlásairól.] Metabolizmus, 2012, 10 (Suppl. A), 2–4. [Hungarian]
Balogh S. , 'Recommendations of the 5th Hungarian Cardiovascular Consensus Conference. [Összefoglalás az V. Magyar Kardiovaszkuláris Konszenzus Konferencia ajánlásairól.] ' (2012 ) 10 Metabolizmus : 2 -4 .
UK prospective diabetes study 27. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex. Diabetes Care, 1997, 20, 1683–1687.
Colhoun, H. M., Betteridge, D. J., Durrington, P. N., et al.: Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet, 2004, 364, 685–696.
Durrington P. N. , 'Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial ' (2004 ) 364 Lancet : 685 -696 .
Cholesterol Treatment Trialists’ (CTT) Collaborators, Kearney, P. M., Blackwell, L., Collins, R., et al.: Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet, 2008, 371, 117–125.
Collins R. , 'Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis ' (2008 ) 371 Lancet : 117 -125 .
Freeman, D. J., Norrie, J., Sattar, N., et al.: Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the west of Scotland coronary prevention study. Circulation, 2001, 103, 357–362.
Sattar N. , 'Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the west of Scotland coronary prevention study ' (2001 ) 103 Circulation : 357 -362 .
Mora, S., Ridker, P. M.: Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) – can C-reactive protein be used to target statin therapy in primary prevention? Am. J. Cardiol., 2006, 97 (2A), 33A–41A.
Ridker P. M. , 'Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) – can C-reactive protein be used to target statin therapy in primary prevention? ' (2006 ) 97 Am. J. Cardiol. : 33A -41A .
Rajpathak, S. N., Kumbhani, D. J., Crandall, J., et al.: Statin therapy and risk of developing type 2 diabetes: a meta-analysis. Diabetes Care, 2009, 32, 1924–1929.
Crandall J. , 'Statin therapy and risk of developing type 2 diabetes: a meta-analysis ' (2009 ) 32 Diabetes Care : 1924 -1929 .
Sattar, N., Preiss, D., Murray, H. M., et al.: Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet, 2010, 375, 735–742.
Murray H. M. , 'Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials ' (2010 ) 375 Lancet : 735 -742 .
Mills, E. J., Wu, P., Chong, G., et al.: Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials. QJM, 2011, 104, 109–124.
Chong G. , 'Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials ' (2011 ) 104 QJM : 109 -124 .
Preiss, D., Seshasai, S. R., Welsh, P., et al.: Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA, 2011, 305, 2556–2564.
Welsh P. , 'Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis ' (2011 ) 305 JAMA : 2556 -2564 .
Yamakawa, T., Takano, T., Tanaka, S., et al.: Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus. J. Atheroscler. Thromb., 2008, 15, 269–275.
Tanaka S. , 'Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus ' (2008 ) 15 J. Atheroscler. Thromb. : 269 -275 .
Simsek, S., Schalkwijk, C. G., Wolffenbuttel, B. H.: Effects of rosuvastatin and atorvastatin on glycaemic control in type 2 diabetes – the CORALL study. Diabet. Med., 2012, 29, 628–631.
Wolffenbuttel B. H. , 'Effects of rosuvastatin and atorvastatin on glycaemic control in type 2 diabetes – the CORALL study ' (2012 ) 29 Diabet. Med. : 628 -631 .
Sasaki, J., Iwashita, M., Kono, S.: Statins: beneficial or adverse for glucose metabolism. J. Atheroscler. Thromb., 2006, 13, 123–129.
Kono S. , 'Statins: beneficial or adverse for glucose metabolism ' (2006 ) 13 J. Atheroscler. Thromb. : 123 -129 .
Ting, R. Z., Yang, X., Yu, L. W., et al.: Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study. Cardiovasc. Diabetol., 2010, 9, 77. doi: 10.1186/1475–2840-9-77
Yu L. W. , 'Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study ' (2010 ) 9 Cardiovasc. Diabetol. : 77 -.
Donath, M. Y., Böni-Schnetzler, M., Ellingsgaard, H., et al.: Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology, 2009, 24, 325–331.
Ellingsgaard H. , 'Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes ' (2009 ) 24 Physiology : 325 -331 .
Mabuchi, H., Higashikata, T., Kawashiri, M., et al.: Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. J. Atheroscler. Thromb., 2005, 12, 111–119.
Kawashiri M. , 'Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients ' (2005 ) 12 J. Atheroscler. Thromb. : 111 -119 .
Armitage, J.: The safety of statins in clinical practice. Lancet, 2007, 370, 1781–1790.
Armitage J. , 'The safety of statins in clinical practice ' (2007 ) 370 Lancet : 1781 -1790 .
Nakata, M., Uto, N., Maruyama, I., et al.: Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6. Cell. Struct. Funct., 1999, 24, 451–455.
Maruyama I. , 'Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6 ' (1999 ) 24 Cell. Struct. Funct. : 451 -455 .
Chamberlain, L. H.: Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. FEBS Lett., 2001, 507, 357–361.
Chamberlain L. H. , 'Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes ' (2001 ) 507 FEBS Lett. : 357 -361 .
Yada, T., Nakata, M., Shiraishi, T., et al.: Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br. J. Pharmacol., 1999, 126, 1205–1213.
Shiraishi T. , 'Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells ' (1999 ) 126 Br. J. Pharmacol. : 1205 -1213 .