Bevezetés: 2011 májusától az 1-es genotípusú hepatitis C-vírussal fertőzöttek standard kezelése a proteázgátló/ribavirin/peginterferon kombináció. Célkitűzés: A szerzők hepatológiai centrumukban retrospektív felmérést végeztek az új kezelésre váró betegekről annak becslésére, hogy az új kezelés milyen arányban hozhat tartós vírusválaszt. Módszer: 2004. január és 2012. szeptember között 269, krónikus hepatitis C-vírus-fertőzöttet kezeltek peginterferon/ribavirin terápiával. 142 beteg nem ért el tartós vírusválaszt, de közülük csak 93-nál jön szóba hármas kombinációs antivirális kezelés. Ez utóbbi betegcsoportban meghatározták a megelőző sikertelen kezelésre adott vírusválaszt, a fibrosis mértékét és 49 betegnél az interleukin-28B genotípust. Eredmények: A megelőző kettős kezelésre adott vírusválasz alapján 25 visszaeső, 26 részlegesen reagáló, hat áttörés és 36 nullreagáló volt a 93 beteg között. A betegek 29%-ának enyhe-mérsékelt és 71%-ának már súlyos fibrosisa van. 49-ből csak nyolc betegnek van interleukin-28B CC genotípusa. Következtetés: Főleg a visszaesőknek, de a részlegesen reagálóknak is jó esélye van a tartós vírusválasz elérésére, amelyet a fibrosis foka is befolyásolhat. Orv. Hetil., 2013, 154, 257–261.
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