View More View Less
  • 1 Debreceni Egyetem, Debrecen
  • 2 Debreceni Egyetem, Debrecen
  • 3 Debreceni Egyetem, Debrecen
  • 4 The Rockefeller University, 1230 York Avenue, Box 163, New York, NY 10065, USA
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

Absztrakt:

Primer immundeficientiákban a társuló szájüregi manifesztációk leggyakrabban fogágybetegség, fogszuvasodás és szájnyálkahártya-betegségek formájában jelentkeznek. A fogszuvasodás kialakulására való fokozott hajlam elsősorban az immunglobulintermelés zavarával járó immunhiány-betegségeket jellemzi, míg a plakk jelenlétéhez köthető fogágybetegség phagocytadefektusokban gyakori. A fogak szerkezeti rendellenessége az apoptózis zavarával járó immunhiányos betegségekben fordulhat elő. A DNS-repair-mechanizmusok defektusával járó immundeficientiákban rosszindulatú szájüregi daganatok is kialakulhatnak. Orv Hetil. 2018; 159(49): 2079–2086.

  • 1

    Szczawinska-Popolonyk A, Gerreth K, Breborowicz A, et al. Oral manifestations of primary immune deficiencies in children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108: e9–e20.

  • 2

    Nualart Grollmus ZC, Morales Chávez MC, Silvestre Donat FJ. Periodontal disease associated to systemic genetic disorders. Med Oral Patol Oral Cir Bucal. 2007; 12: E211–E215.

  • 3

    Tar I, Kiss C, Maródi L, et al. Oral and dental conditions of children with selective IgA deficiency. Pediatr Allergy Immunol. 2008; 19: 33–36.

  • 4

    Grimbacher B, Holland SM, Gallin JI, et al. Hyper IgE syndrome with recurrent infections: an autosomal dominant multisystem disorder. N Engl J Med. 1999; 340: 692–702.

  • 5

    Bousfiha A, Jeddane L, Picard C, et al. The 2017 IUIS phenotypic classification for primary immunodeficiencies. J Clin Immunol. 2018; 38: 129–143. [Epub 2017 Dec 11]

  • 6

    Picard C, Bobby Gaspar H, Al-Herz W, et al. International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee report on inborn errors of immunity. J Clin Immunol. 2018; 38: 96–128. [Epub 2017 Dec 11]

  • 7

    Armitage GC. Development of a classification system for periodontal disease and conditions. Ann Periodontol. 1999; 4: 1–6.

  • 8

    Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and the host response. Trends Immunol. 2014; 35: P3–P11.

  • 9

    Zijnge V, van Leeuwen MB, Degener JE, et al. Oral biofilm architecture on natural teeth. PLoS ONE 2010; 5: e9321.

  • 10

    Dinauer MC. Primary immune deficiencies with defects in neutrophyl function. Hematology Am Soc Hematol Educ Program 2016; 2016: 43–50.

  • 11

    Majorana A, Notarangelo LD, Savoldi E, et al. Leukocyte adhesion deficiency in a child with severe oral involvement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 87: 691–694.

  • 12

    Moutsopoulos NM, Chalmers NI, Barb JJ, et al. Subgingival microbial communities in leukocyte adhesion deficiency and their realtionship with local immunopathology. PLoS Pathog. 2015; 11: e1004698.

  • 13

    Manji F, Dahlén G, Fejerskov O. Caries and periodontitis: contesting the conventional wisdom on their etiology. Caries Res. 2018; 52: 548–564.

  • 14

    Elhennawy K, Manton DJ, Crombie F, et al. Structural, mechanical and chemical evaluation of molar-incisor hypomineralization-affected enamel: a systematic review. Arch Oral Biol. 2017; 83: 272–281.

  • 15

    Chung Leng Muñoz I, Beltri Orta P. Comparison of cephalometric patterns in mouth breathing and nose breathing children. Int J Pediatr Otorhinolaryngol. 2014; 78: 1167–1172.

  • 16

    Batista EL Jr, Novaes AB Jr, Calvano LM, et al. Necrotizing ulcerative periodontitis associated with severe congenital immunodeficiency in a prepubescent subject: clinical findings and response to intravenous immunoglobulin treatment. J Clin Periodontol. 1999; 26: 499–504.

  • 17

    Malek R, Gharibi A, Khlil N, et al. Necrotizing ulcerative gingivitis. Contemp Clin Dent. 2017; 8: 496–500.

  • 18

    He Y, Chen Q, Li B. ATM in oral carcinogenesis: association with clinicopathological features. J Cancer Res Clin Oncol. 2008; 134: 1013–1020.

  • 19

    Klingberg G, Hallberg U, Óskarsdóttir S. Oral health and 22q11 deletion syndrome: thoughts and experiences from the parents perspectives. Int J Paediatr Dent. 2010; 20: 283–292.

  • 20

    Nyul Z, Hadzsiev K, Andrásofszky Z, et al. DiGeorge syndrome in child born by in vitro fertilization. [DiGeorge-szindróma in vitro fertilizációval született gyermekben.] Gyermekgyógyászat 2005; 56: 153–157. [Hungarian]

  • 21

    Jiao H, Tóth B, Erdős M, et al. Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups. Mol Immunol. 2008; 46: 202–206.

  • 22

    Erdős M, Maródi L. Clinical manifestations in hyper-IgE syndrome. [Klinikai manifesztációk hyper-IgE szindrómában.] Gyermekgyógyászat 2004; 55: 15–25. [Hungarian]

  • 23

    Zhang B, Meng B, Viloria E, et al. The role of epithelial STAT3 in amelogenesis during mouse incisor renewal. Cells Tissues Organs 2018; 205: 63–71.

  • 24

    Costa FS, Silveira ER, Pinto GS, et al. Developmental defects of enamel and dental caries in primary dentition: a systematic review and meta-analysis. J Dent. 2017; 60: 1–7.

  • 25

    O’Connell AC, Puck JM, Grimbacher B, et al. Delayed eruption of permanent teeth in hyperimmunoglobulinemia E recurrent infection syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89: 177–185.

  • 26

    Freeman AF, Domingo DL, Holland SM. Hyper IgE (Job’s) syndrome: a primary immune deficiency with oral manifestations. Oral Dis. 2009; 15: 2–7.

  • 27

    Atkinson JC, Harvey KE, Domingo DL, et al. Oral and dental phenotype of dyskeratosis congenita. Oral Dis. 2008; 14: 419–427.

  • 28

    Reiger Z, Varga G, Tóth B, et al. Molecular diagnosis and therapeutic measures in patients with dyskeratosis congenita. [Dyskeratosis congenita: molekuláris diagnosztika és terápiás lehetőségek.] Orv Hetil. 2010; 151: 285–292. [Hungarian]

  • 29

    Reiger Z, Varga G, Tóth B, et al. Dyskeratosis congenita diagnosed in adulthood. [Felnőttkorban diagnosztizált dyskeratosis congenita.] Gyermekgyógyászat 2010; 61: 66–70. [Hungarian]

  • 30

    Fernandes KS, Kokron CM, Barros MT, et al. Oral manifestations in patients with hypogammaglobulinemia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 114: e19–e24.

  • 31

    Muñoz F, Del Río N, Sóñora C, et al. Enamel defects associated with coeliac disease: putative role of antibodies against gliadin in pathogenesis. Eur J Oral Sci. 2012; 120: 104–112.

  • 32

    Tar I, Nemes É, Nemes J, et al. The role of salivary immunoglobulins (secretory IgA, IgM, IgG) in caries prevalence and primary B-cell deficiency. [A nyálimmunglobulinok (szekretoros IgA, IgM, IgG) mennyiségének és a cariesprevalencia közötti összefüggés vizsgálata deficienciákban (primer B-sejt).] Fogorv Szle. 1999; 92: 331–338. [Hungarian]

  • 33

    Mooney J, Adonogianaki M, Riggio MP, et al. Initial serum antibody titer to Porphyromonas gingivalis influences development of antibody avidity and success of therapy for chronic periodontitis. Infect Immun. 1995; 63: 3411–3416.

  • 34

    Chung HY, Lu HC, Chen WL, et al. Immunglobulin G profiles in different forms of periodontitis. J Periodontal Res. 2003; 38: 471–476.

  • 35

    Ferre EM, Rose SR, Rosenzweig SD, et al. Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. JCI Insight 2016; 1: e88782.

  • 36

    Shibutani T, Gen K, Shibata M, et al. Long-term follow-up of periodontitis in a patient with Chédiak–Higashi syndrome. A case report. J Periodontol. 2000; 71: 1024–1028.

  • 37

    Budunelli N, Baylas H, Aksu G, et al. Prepubertal periodontitis associated with chronic granulomatous disease. J Clin Periodontol. 2001; 28: 589–593.

  • 38

    Dar-Odeh NS, Hayajneh WA, Abu-Hammad OA, et al. Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature. BMC Res Notes 2010; 3: 37.

  • 39

    Gungor OE, Karayilmaz H, Yalcin H, et al. Oro-dental characteristics of three siblings with Papillon–Lefevre syndrome. Niger J Clin Pract. 2017; 20: 256–260.

  • 40

    Soltész B, Tóth B, Shabashova N, et al. New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe. J Med Genet. 2013; 50: 567–578.

  • 41

    Maródi L. Mucocutaneous candidiasis. In: Sullivan KE, Stiehm ER. (eds.) Stiehm’s immune deficiencies. Elsevier, London, 2014; pp. 775–802.

  • 42

    Erdős M, Maródi L. Autoinflammatory syndromes – recurrent fever syndromes. [Autoinflammációs szindrómák – visszatérő lázszindrómák.] Focus Medicinae 2010; 12: 3–16. [Hungarian]

  • 43

    Erdős M, Maródi L. Fever and fever syndromes. [Láz és lázszindrómák.] Gyermekorv Továbbk. 2010; 9: 9–11. [Hungarian]

  • 44

    Roberts T, Stephen L, Scott C, et al. CANDLE syndrome: orofacial manifestations and dental implications. Head Face Med. 2015; 11: 38.

  • 45

    Márton K. Oral symptoms of immunologic disorders. Part I. Systemic autoimmune diseases. [Immunológiai kórképek fogorvosi vonatkozásai I. Szisztémás autoimmun betegségek.] Fogorv Szle. 2003; 96: 9–15. [Hungarian]