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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Nagyvárad tér 4., 1089
  • 2 Uzsoki utcai Kórház, Budapest
Open access

Absztrakt:

Az ösztrogénhormonok metabolizmusa során oxidált formák, szerkezeti izomerek és konjugált termékek jelennek meg számos szövetben lokálisan, emellett a szisztémás keringésben. A metabolizmus megváltozása feltételezhetően számos kórfolyamattal összefügg. A célzott ösztrogénmetabolomikai kutatásokra idáig jórészt postmenopausalis, illetve malignitásokkal és adverz immunrendszeri folyamatokkal összefüggésben került sor. Noha az ösztriol gestatiót fenntartó szerepe és az ösztrogénmetabolitok biológiai aktivitása ismert, viszonylag kis számú közleményben foglalkoztak e vegyületek várandósság alatti keletkezésével és átalakulásaival. Áttekintő közleményünkben bemutatjuk az ösztrogénmetabolitok terhesség alatt történő képződését, illetve összefoglaljuk az ismereteket a gestatiós komplikációkban azonosított szerepükre vonatkozóan. Orv Hetil. 2019; 160(26): 1007–1014.

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