Authors:
Carlo Vecchia

Search for other papers by Carlo Vecchia in
Current site
Google Scholar
PubMed
Close
and
Cristina Bosetti Istituto di Ricerche Farmacologiche “Mario Negri” via Eritrea, 62 20157 Milano Italy

Search for other papers by Cristina Bosetti in
Current site
Google Scholar
PubMed
Close
Restricted access

Various aspects of the Mediterranean diet were analyzed in a series of studies conducted in Northern Italy on over 20,000 cases of several major cancers and 18,000 controls. For most digestive tract cancers, the risk decreased with increasing vegetable and fruit consumption, with relative risks between 0.3 and 0.7 for the highest level of intake, and the population attributable risks for low intake of vegetables and fruit ranged between 15 and 40%. Less strong inverse relations were observed for other (epithelial) cancers, too. A number of micronutrients contained in vegetables and fruit showed an inverse relation with cancer risk. In particular, flavones, flavonols and resveratrol were inversely related to breast cancer risk. Olive oil, which is the main common denominator of the Mediterranean diet, has also been inversely related to cancers of the colorectum and breast, and mainly of the upper digestive and respiratory tract.

  • Trichopoulou, A., Lagiou, P., Kuper, H., Trichoupulos, D.: Cancer and Mediterranean dietary traditions. Cancer Epidemiol. Biomarkers Prev., 2000, 9 , 869–873.

    Trichoupulos D. , 'Cancer and Mediterranean dietary traditions ' (2000 ) 9 Cancer Epidemiol. Biomarkers Prev. : 869 -873 .

    • Search Google Scholar
  • La Vecchia, C., Chatenoud, L., Franceschik, S., Soler, M., Parazzini, F., Negri, E.: Vegetables and fruit and human cancer. Update of an Italian study. Int. J. Cancer, 1999, 82 , 151–152.

    Negri E. , 'Vegetables and fruit and human cancer. Update of an Italian study ' (1999 ) 82 Int. J. Cancer : 151 -152 .

    • Search Google Scholar
  • Negri, E., La Vecchia, C., Franceschi, S., D’Avanzo, B., Talamini, R., Parpinel, M., Ferraroni, M., Filiberti, R., Montella, M., Falcini, F., Conti, E., Decarli, A.: Intake of selected micronutrients and the risk of breast cancer. Int. J. Cancer, 1996, 65 , 140–144.

    Decarli A. , 'Intake of selected micronutrients and the risk of breast cancer ' (1996 ) 65 Int. J. Cancer : 140 -144 .

    • Search Google Scholar
  • Bidoli, E., Bosetti, C., La Vecchia, C., Levi, F., Parpinel, M., Talamini, R., Negri, E., Dal Maso, L., Franceschi, S.: Micronutrients and laryngeal cancer risk in Italy and Switzerland. A case-control study. Cancer Causes Control, 2003, 14 , 477–484.

    Franceschi S. , 'Micronutrients and laryngeal cancer risk in Italy and Switzerland. A case-control study ' (2003 ) 14 Cancer Causes Control : 477 -484 .

    • Search Google Scholar
  • Negri, E., Franceschi, S., Bosetti, C., Levi, F., Parpinel, M., La Vecchia, C.: Selected micronutrients and oral and pharyngeal cancer. Int. J. Cancer, 2000, 86 , 122–127.

    Vecchia C. , 'Selected micronutrients and oral and pharyngeal cancer ' (2000 ) 86 Int. J. Cancer : 122 -127 .

    • Search Google Scholar
  • La Vecchia, C., D’Avanzo, B., Decarli, A., Franceschi, S.: Selected micronutrient intake and the risk of gastric cancer. Cancer Epidemiol. Biomarkers Prev., 1994, 3 , 393–398.

    Franceschi S. , 'Selected micronutrient intake and the risk of gastric cancer ' (1994 ) 3 Cancer Epidemiol. Biomarkers Prev. : 393 -398 .

    • Search Google Scholar
  • La Vecchia, C.: Tomatoes, lycopene intake, and digestive tract and female hormone-related neoplasms. Exp. Biol. Med. (Maywood), 2002, 227 , 860–863.

    Vecchia C. , 'Tomatoes, lycopene intake, and digestive tract and female hormone-related neoplasms ' (2002 ) 227 Exp. Biol. Med. (Maywood) : 860 -863 .

    • Search Google Scholar
  • Bosetti, C., Talamini, R., Montella, M., Negri, E., Conti, E., Franceschi, S., La Vecchia, C.: Retinol, carotenoids and the risk of prostate cancer, A case-control study from Italy. Int. J. Cancer, 2004, 112 , 689–692.

    Vecchia C. , 'Retinol, carotenoids and the risk of prostate cancer, A case-control study from Italy ' (2004 ) 112 Int. J. Cancer : 689 -692 .

    • Search Google Scholar
  • La Vecchia, C., Braga, C., Negri, E., Franceschi, S., Russo, A., Conti, E., Falcini, F., Giacosa, A., Montella, M., Decarli, A.: Intake of selected micronutrients and the risk of colorectal cancer. Int. J. Cancer, 1997, 73 , 525–530.

    Decarli A. , 'Intake of selected micronutrients and the risk of colorectal cancer ' (1997 ) 73 Int. J. Cancer : 525 -530 .

    • Search Google Scholar
  • Duthie, S. J.: Folic acid deficiency and cancer: mechanisms of DNA instability. Br. Med. Bull., 1999, 55 , 578–592.

    Duthie S. J. , 'Folic acid deficiency and cancer: mechanisms of DNA instability ' (1999 ) 55 Br. Med. Bull. : 578 -592 .

    • Search Google Scholar
  • Pelucchi, C., Talamini, R., Negri, E., Levi, F., Conti, E., Franceschi, S., La Vecchia, C.: Folate intake and risk of oral and pharyngeal cancer. Ann. Oncol., 2003, 14 , 1677–1681.

    Vecchia C. , 'Folate intake and risk of oral and pharyngeal cancer ' (2003 ) 14 Ann. Oncol. : 1677 -1681 .

    • Search Google Scholar
  • Franceschi, S., Bidoli, E., Negri, E., Zambon, P., Talamini, R., Ruol, A., Parpinel, M., Levi, F., La Vecchia, C.: Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Int. J. Cancer, 2000, 86 , 626–631.

    Vecchia C. , 'Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus ' (2000 ) 86 Int. J. Cancer : 626 -631 .

    • Search Google Scholar
  • La Vecchia, C., Negri, E., Pelucchi, C., Franceschi, S.: Dietary folate and colorectal cancer. Int. J. Cancer, 2002, 102 , 545–547.

    Franceschi S. , 'Dietary folate and colorectal cancer ' (2002 ) 102 Int. J. Cancer : 545 -547 .

    • Search Google Scholar
  • Negri, E., La Vecchia, C., Franceschi S.: Dietary folate consumption and breast cancer risk (reply to). J. Natl. Cancer Inst., 2000, 92 , 1270–1271.

    Franceschi S. , 'Dietary folate consumption and breast cancer risk (reply to) ' (2000 ) 92 J. Natl. Cancer Inst. : 1270 -1271 .

    • Search Google Scholar
  • Pelucchi, C., Galeone, C., Talamini, R., Negri, E., Parpinel, M., Franceschi, S., Montella, M., La Vecchia, C.: Dietary folate and risk of prostate cancer in Italy. Cancer Epidemiol. Biomarkers Prev., 2005, 14 , 944–948.

    Vecchia C. , 'Dietary folate and risk of prostate cancer in Italy ' (2005 ) 14 Cancer Epidemiol. Biomarkers Prev. : 944 -948 .

    • Search Google Scholar
  • Peterson, J., Lagiou, P., Samoli, E., Lagiou, A., Katsouyanni, K., La Vecchia, C., Dwyer, J., Trichopoulos, D.: Flavonoid intake and breast cancer risk: a case-control study in Greece. Br. J. Cancer, 2003, 89 , 1255–1259.

    Trichopoulos D. , 'Flavonoid intake and breast cancer risk: a case-control study in Greece ' (2003 ) 89 Br. J. Cancer : 1255 -1259 .

    • Search Google Scholar
  • Bosetti, C., Spertini, L., Parpinel, M., Gnagnarella, P., Lagiou P, Negri, E., Franceschi, S., Montella, M., Peterson, J., Dwyer, J., Giacosa, A., La Vecchia, C.: Flavonoids and breast cancer risk in Italy. Cancer Epidemiol. Biomarkers Prev., 2005, 14 , 805–808.

    Vecchia C. , 'Flavonoids and breast cancer risk in Italy ' (2005 ) 14 Cancer Epidemiol. Biomarkers Prev. : 805 -808 .

    • Search Google Scholar
  • Levi, F., Pasche, C., Lucchini F, Ghidoni R, Ferraroni, M., La Vecchia, C.: Resveratrol and breast cancer risk. Eur. J. Cancer Prev., 2005, 14 , 139–142.

    Vecchia C. , 'Resveratrol and breast cancer risk ' (2005 ) 14 Eur. J. Cancer Prev. : 139 -142 .

    • Search Google Scholar
  • Tavani, A., La Vecchia, C., Gallus, S., Lagiou, P., Trichopoulos, D., Levi, F., Negri E.: Red meat intake and cancer risk: a study in Italy. Int. J. Cancer, 2000, 86 , 425–428.

    Negri E. , 'Red meat intake and cancer risk: a study in Italy ' (2000 ) 86 Int. J. Cancer : 425 -428 .

    • Search Google Scholar
  • Fernandez, E., Chatenoud, L., La Vecchia, C., Negri, E., Franceschi, S.: Fish consumption and cancer risk. Am. J. Clin. Nutr., 1999, 70 , 85–90.

    Franceschi S. , 'Fish consumption and cancer risk ' (1999 ) 70 Am. J. Clin. Nutr. : 85 -90 .

    • Search Google Scholar
  • Tavani, A., Pelucchi, C., Parpinel, M., Negri, E., Franceschi, S., Levi, F., La Vecchia, C.: N-3 polyunsaturated fatty acid intake and cancer risk in Italy and Switzerland. Int. J. Cancer, 2003, 105 , 113–116.

    Vecchia C. , 'N-3 polyunsaturated fatty acid intake and cancer risk in Italy and Switzerland ' (2003 ) 105 Int. J. Cancer : 113 -116 .

    • Search Google Scholar
  • Alexander, J. W.: Immunonutrition: The role of omega-3 fatty acids. Nutrition, 1998, 14 , 627–633.

    Alexander J. W. , 'Immunonutrition: The role of omega-3 fatty acids ' (1998 ) 14 Nutrition : 627 -633 .

    • Search Google Scholar
  • Grimble, R. F.: Nutritional modulation of immune function. Proc. Nutr. Soc., 2001, 60 , 389–397.

    Grimble R. F. , 'Nutritional modulation of immune function ' (2001 ) 60 Proc. Nutr. Soc. : 389 -397 .

    • Search Google Scholar
  • Grant, W. B.: Fish consumption, cancer, and Alzheimer disease. Am. J. Clin. Nutr., 2000, 71 , 599–603.

    Grant W. B. , 'Fish consumption, cancer, and Alzheimer disease ' (2000 ) 71 Am. J. Clin. Nutr. : 599 -603 .

    • Search Google Scholar
  • Rose, D. P., Connolly, J. M.: Omega–3 fatty acids as cancer chemopreventive agents. Pharmacol. Ther., 1999, 83 , 217–244.

    Connolly J. M. , 'Omega–3 fatty acids as cancer chemopreventive agents ' (1999 ) 83 Pharmacol. Ther. : 217 -244 .

    • Search Google Scholar
  • Marckmann, P., Grønbaek, M.: Fish consumption and coronary heart disease mortality: A systematic review of prospective cohort studies. Eur. J. Clin. Nutr., 1999, 53 , 585–590.

    Grønbaek M. , 'Fish consumption and coronary heart disease mortality: A systematic review of prospective cohort studies ' (1999 ) 53 Eur. J. Clin. Nutr. : 585 -590 .

    • Search Google Scholar
  • GISSI-Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico): Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-prevenzione trial. Lancet, 1999, 354 , 447–455.

    'Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-prevenzione trial ' (1999 ) 354 Lancet : 447 -455 .

    • Search Google Scholar
  • Chatenoud, L., Tavani, A., La Vecchia, C., Jacobs, D. R., Jr., Negri, E., Levi, F., Franceschi, S.: Whole grain food intake and cancer risk. Int. J. Cancer, 1998, 77 , 24–28.

    Franceschi S. , 'Whole grain food intake and cancer risk ' (1998 ) 77 Int. J. Cancer : 24 -28 .

    • Search Google Scholar
  • Negri, E., Franceschi, S., Parpinel, M., La Vecchia, C.: Fibre intake and risk of colorectal cancer. Cancer Epidemiol. Biomarkers Prev., 1998, 7 , 667–671.

    Vecchia C. , 'Fibre intake and risk of colorectal cancer ' (1998 ) 7 Cancer Epidemiol. Biomarkers Prev. : 667 -671 .

    • Search Google Scholar
  • Fernandez, E., La Vecchia, C., Gonzalez, J. R., Lucchini, F., Negri, E., Levi, F.: Converging patterns of colorectal cancer mortality in Europe. Eur. J. Cancer, 2005, 41 , 430–437.

    Levi F. , 'Converging patterns of colorectal cancer mortality in Europe ' (2005 ) 41 Eur. J. Cancer : 430 -437 .

    • Search Google Scholar
  • Franceschi, S., Russo, A., La Vecchia, C.: Carbohydrates, fat and cancer of the breast and colon-rectum. J. Epidemiol. Biostat., 1998, 3 , 217–218.

    Vecchia C. , 'Carbohydrates, fat and cancer of the breast and colon-rectum ' (1998 ) 3 J. Epidemiol. Biostat. : 217 -218 .

    • Search Google Scholar
  • Chatenoud, L., La Vecchia, C., Franceschi, S., Tavani, A., Jacobs, D. R. Jr., Parpinel, M. T., Soler, M., Negri, E.: Refined-cereal intake and risk of selected cancers in Italy. Am. J. Clin. Nutr., 1999, 70 , 1107–1110.

    Negri E. , 'Refined-cereal intake and risk of selected cancers in Italy ' (1999 ) 70 Am. J. Clin. Nutr. : 1107 -1110 .

    • Search Google Scholar
  • Franceschi, S., Dal Maso, L., Augustin, L., Negri, E., Parpinel, M., Boyle, P., Jenkins, D. J., La Vecchia, C.: Dietary glycaemic load and colorectal cancer risk. Ann. Oncol., 2001, 12 , 173–178.

    Vecchia C. , 'Dietary glycaemic load and colorectal cancer risk ' (2001 ) 12 Ann. Oncol. : 173 -178 .

    • Search Google Scholar
  • Augustin, L. S., Dal Maso, L., La Vecchia, C., Parpinel, M., Negri, E., Vaccarella, S., Kendall, C. W., Jenkins, D. J., Franceschi, S.: Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Ann. Oncol., 2001, 12 , 1533–1538.

    Franceschi S. , 'Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study ' (2001 ) 12 Ann. Oncol. : 1533 -1538 .

    • Search Google Scholar
  • Augustin, L. S., Gallus, S., Negri, E., La Vecchia, C.: Glycemic index, glycemic load and risk of gastric cancer. Ann. Oncol., 2004, 15 , 581–584.

    Vecchia C. , 'Glycemic index, glycemic load and risk of gastric cancer ' (2004 ) 15 Ann. Oncol. : 581 -584 .

    • Search Google Scholar
  • Augustin, L. S., Galeone, C., Dal Maso, L., Pelucchi, C., Ramazzotti, V., Jenkins, D. J., Montella, M., Talamini, R., Negri, E., Franceschi, S., La Vecchia, C.: Glycemic index, glycemic load and the risk of prostate cancer. Int. J. Cancer, 2004, 112 , 446–450.

    Vecchia C. , 'Glycemic index, glycemic load and the risk of prostate cancer ' (2004 ) 112 Int. J. Cancer : 446 -450 .

    • Search Google Scholar
  • Augustin, L. S., Polesel, J., Bosetti, C., Kendall, C. W., La Vecchia, C., Parpinel, M., Conti, E., Montella, M., Franceschi, S., Jenkins, D. J., Dal Maso, L.: Dietary glycemic index, glycemic load and ovarian cancer risk: A case-control study in Italy. Ann. Oncol., 2003, 14 , 78–84.

    Maso L. , 'Dietary glycemic index, glycemic load and ovarian cancer risk: A case-control study in Italy ' (2003 ) 14 Ann. Oncol. : 78 -84 .

    • Search Google Scholar
  • Augustin, L. S., Gallus, S., Franceschi, S., Negri, E., Jenkins, D. J., Kendall, C. W., Dal Maso, L., Talamini, R., La Vecchia, C.: Glycemic index and load and risk of upper aero-digestive tract neoplasms (Italy). Cancer Causes Control, 2003, 14 , 657–662.

    Vecchia C. , 'Glycemic index and load and risk of upper aero-digestive tract neoplasms (Italy) ' (2003 ) 14 Cancer Causes Control : 657 -662 .

    • Search Google Scholar
  • Augustin, L. S., Gallus, S., Bosetti, C., Levi, F., Negri, E., Franceschi, S., Dal Maso, L., Jenkins, D. J., Kendall, C. W., La Vecchia, C.: Glycemic index and glycemic load in endometrial cancer. Int. J. Cancer, 2003, 105 , 404–407.

    Vecchia C. , 'Glycemic index and glycemic load in endometrial cancer ' (2003 ) 105 Int. J. Cancer : 404 -407 .

    • Search Google Scholar
  • La Vecchia, C., Negri, E., Franceschi, S., Decarli, A., Giacosa, A., Lipworth, L.: Olive oil, other dietary fats, and the risk of breast cancer (Italy). Cancer Causes Control, 1995, 6 , 545–550.

    Lipworth L. , 'Olive oil, other dietary fats, and the risk of breast cancer (Italy) ' (1995 ) 6 Cancer Causes Control : 545 -550 .

    • Search Google Scholar
  • Prieto-Ramos, F., Serra-Majem, L., La Vecchia, C., Ramon, J. M., Tresserras, R., Salieras L.: Mortality trends and past and current dietary factors of breast cancer in Spain. Eur. J. Epidemiol., 1996, 12 , 141–148.

    Salieras L. , 'Mortality trends and past and current dietary factors of breast cancer in Spain ' (1996 ) 12 Eur. J. Epidemiol. : 141 -148 .

    • Search Google Scholar
  • Trichopoulou, A.: Olive oil and breast cancer. Cancer Causes Control, 1995, 6 , 475–476.

    Trichopoulou A. , 'Olive oil and breast cancer ' (1995 ) 6 Cancer Causes Control : 475 -476 .

    • Search Google Scholar
  • Bosetti, C., Micelotta, S., Dal Maso, L., Talamini, R., Montella, M., Negri, E., Conti, E., Franceschi, S., La Vecchia, C.: Food groups and risk of prostate cancer in Italy. Int. J. Cancer, 2004, 110 , 424–428.

    Vecchia C. , 'Food groups and risk of prostate cancer in Italy ' (2004 ) 110 Int. J. Cancer : 424 -428 .

    • Search Google Scholar
  • Braga, C., La Vecchia, C., Franceschi, S., Negri, E., Parpinel, M., Decarli, A., Giacosa, A., Trichopoulos, D.: Olive oil, other seasoning fats, and the risk of colorectal carcinoma. Cancer, 1998, 82 , 448–453.

    Trichopoulos D. , 'Olive oil, other seasoning fats, and the risk of colorectal carcinoma ' (1998 ) 82 Cancer : 448 -453 .

    • Search Google Scholar
  • Franceschi, S., Favero, A., Conti, E., Talamini, R., Volpe, R., Negri, E., Barzan, L., La Vecchia, C.: Food groups, oils and butter and cancer of the oral cavity and pharynx. Br. J. Cancer, 1999, 80 , 614–620.

    Vecchia C. , 'Food groups, oils and butter and cancer of the oral cavity and pharynx ' (1999 ) 80 Br. J. Cancer : 614 -620 .

    • Search Google Scholar
  • Bosetti, C., La Vecchia, C., Talamini, R., Negri, E., Levi, F., Dal Maso, L., Franceschi, S.: Food groups and laryngeal cancer risk: a case-control study from Italy and Switzerland. Int. J. Cancer, 2002, 100 , 355–360.

    Franceschi S. , 'Food groups and laryngeal cancer risk: a case-control study from Italy and Switzerland ' (2002 ) 100 Int. J. Cancer : 355 -360 .

    • Search Google Scholar
  • Bosetti, C., La Vecchia, C., Talamini, R., Simonato, L., Zambon, P., Negri, E., Trichopoulos, D., Lagiou, P., Bardini, R., Franceschi, S.: Food groups and risk of squamous cell esophageal cancer in Northern Italy. Int. J. Cancer, 2000, 87 , 289–294.

    Franceschi S. , 'Food groups and risk of squamous cell esophageal cancer in Northern Italy ' (2000 ) 87 Int. J. Cancer : 289 -294 .

    • Search Google Scholar
  • Gallus, S., Bosetti, C., Negri, E., Talamini, R., Montella, M., Conti, E., Franceschi, S., La Vecchia, C.: Does pizza protect against cancer? Br. J. Cancer, 2003, 107 , 283–284.

    Vecchia C. , 'Does pizza protect against cancer? ' (2003 ) 107 Br. J. Cancer : 283 -284 .

    • Search Google Scholar
  • Gallus, S., Talamini, R., Bosetti, C., Negri, E., Montella, M., Franceschi, S., Giacosa, A., La Vecchia, C.: Pizza consumption and the risk of breast, ovarian and prostate cancer. Eur. J. Cancer Prev., 2006, 15 , 74–76.

    Vecchia C. , 'Pizza consumption and the risk of breast, ovarian and prostate cancer ' (2006 ) 15 Eur. J. Cancer Prev. : 74 -76 .

    • Search Google Scholar
  • Bosetti, C., Gallus S., Trichopoulou, A., Talamini, R., Franceschi, S., Negri, E., La Vecchia, C.: Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract. Cancer Epidemiol. Biomarkers Prev., 2003, 12 , 1091–1094.

    Vecchia C. , 'Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract ' (2003 ) 12 Cancer Epidemiol. Biomarkers Prev. : 1091 -1094 .

    • Search Google Scholar
  • Gallus, S., Bosetti, C., La Vecchia, C.: Mediterranean diet and cancer risk. Eur. J. Cancer Prev., 2004, 13 , 447–452.

    Vecchia C. , 'Mediterranean diet and cancer risk ' (2004 ) 13 Eur. J. Cancer Prev. : 447 -452 .

    • Search Google Scholar
  • Collapse
  • Expand

Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)