Hungarian Medical Journal
Volume/Issue:
Volume 1: Issue 1
Hepatitis C Virus Infection and Depression
Authors:
Gabriella Lengyel Semmelweis University Medical School 2nd Department of Internal Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Zsuzsa Aszalós Research Group of Gastroenterology and Endocrinology of the Hungarian Academy of Sciences and Semmelweis University Budapest Hungary

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Zsolt Tulassay Semmelweis University Medical School 2nd Department of Internal Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Pages:
55–62
Online Publication Date:
16 Apr 2007
Publication Date:
01 Jan 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/oh-hmj.2007.27952
Keywords:
hepatitis C virus; chronic hepatitis C; interferon-α; depression; antidepressants
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Approximately 170 million people worldwide suffer from chronic hepatitis C. Depression is more prevalent among people with chronic viral hepatitis C as compared to the normal population; it can be identified in about 58% of patients. Based on the literature, the authors review the aetiology of depression occurring in hepatic disease, with regard to the neuropathogenic activity of hepatitis C virus (HCV). They report research results that may serve as evidence for alterations caused by the hepatitis C virus in the central nervous system. Depression is one of the side effects of interferon-α used for treating HCV infection. The authors discuss the biologic bases, the development and the consequences of depression caused by interferon in chronic hepatitis C, and they review the course of assessing patients with depression. They summarise the steps of psychiatric pharmacotherapy in chronic liver diseases. It is important to consider, whether a patient with chronic hepatitis C and depression can be treated with interferon. Missing interferon therapy may lead to a fatal outcome of the hepatic disease. In order to come to a prudent decision an appropriate cooperation is needed between physician and psychiatrist.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
Volumes
per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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