Hungarian Medical Journal
Volume/Issue:
Volume 1: Issue 1
Treatment of Iatrogenic Cushing’s Syndrome: Questions of Glucocorticoid Withdrawal
Authors:
Peter Igaz Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Károly Rácz Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Miklós Tóth Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Edith Gláz Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Zsolt Tulassay

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Pages:
63–72
Online Publication Date:
16 Apr 2007
Publication Date:
01 Jan 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/oh-hmj.2007.27964
Keywords:
iatrogenic; hypercortisolism; glucocorticoid; withdrawal; secondary adrenal insufficiency
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Iatrogenic Cushing’s syndrome is the most common form of hypercortisolism. Glucocorticoids are widely used for the treatment of various diseases, often in high doses that may lead to the development of severe hypercortisolism. Iatrogenic hypercortisolism is unique, as the application of exogenous glucocorticoids leads to the simultaneous presence of symptoms specific for hypercortisolism and the suppression of the endogenous hypothalamic-pituitary-adrenal axis. The principal question of its therapy is related to the problem of glucocorticoid withdrawal. There is considerable interindividual variability in the suppression and recovery of the hypothalamic-pituitary-adrenal axis, therefore, glucocorticoid withdrawal and substitution can only be conducted in a stepwise manner with careful clinical follow-up and regular laboratory examinations regarding endogenous hypothalamic-pituitary-adrenal axis activity. Three major complications which can be associated with glucocorticoid withdrawal are: i. reactivation of the underlying disease, ii. secondary adrenal insufficiency, iii. steroid withdrawal syndrome. Here, the authors summarize the most important aspects of this area based on their clinical experience and the available literature data.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
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per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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