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Zsófia Tömböl Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Peter Szabó Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Károly Rácz Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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Zsolt Tulassay

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Peter Igaz Faculty of Medicine, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary

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MicroRNA molecules consisting of 19–23 nucleotides influence numerous basic physiological and pathophysiological processes, as endogenous mediators of RNA interference. These molecules are capable of specifically inhibiting the translation of messenger RNA molecules, but in some cases also promote the degradation of mRNA-s. Altered microRNA expression profiles were noted in some human diseases, most data, however, are known for neoplasms. Characteristic microRNA profiles are known both in solid and haematologic malignancies. MicroRNA profiles enable the distinction of benign follicular adenomes from follicular neoplasms of the thyroid. The microRNA expression patterns could be associated with the clinical behaviour of certain tumours (e.g. lung tumours and chronic lymphocytic leukemia) as well. It is possible that small molecular weight RNA-s may be used for therapeutical purposes in the future.

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Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)