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  • 1 Jos University Teaching Hospital/AIDS Prevention Initiative in Nigeria (APIN) Plus Project, APIN Centre Department of Medicine PMB 2076 Jos Plateau State Nigeria
  • 2 Jos University Teaching Hospital APIN Laboratory Nigeria
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Objective: To determine the relationship between the immunological status and anti-HCV detection of HIV-1 infected individuals in an HIV/AIDS cohort within an African population. Design: Retrospective study of randomly selected HIV/AIDS patients. Methods: The biodata of 1044 consenting HIV infected patients were analyzed retrospectively. These patients had been enrolled following the confirmation of their HIV status by western blot assay after an initial reactive ELISA. Blood obtained from the patients were subjected to serological tests to determine their anti-HCV antibody status using third generation Enzyme Immunoassay (DIA.PRO Diagnostic, Bioprobes srl, Italy). CD4 count was done by flow cytometry (Partec Cyflow, Germany) and viral load by PCR (Roche Amplicor 1.50). The data were analyzed using the Epi Info 2004 statistical software. Results: Ninety out of 1044 patients (8.6%) were positive for anti-HCV antibodies. The rate of HCV infection was directly proportional to the CD4+ group (6.8% vs. 15.4% for < 201 and > 800, respectively, p = 0.026). Conclusion: There is an associated higher chance of detecting anti-HCV in sera of the HIV-1 infected patients whose immunological status are better compared to severely immunocompromised ones.

  • Sulkowski, M., Thomas, D.: Hepatitis C in the HIV-infected person. Ann. Intern. Med., 2003, 138 , 197–207.

    Thomas D. , 'Hepatitis C in the HIV-infected person ' (2003 ) 138 Ann. Intern. Med. : 197 -207.

    • Search Google Scholar
  • Garcia-Samaniego, J., Soriano, V., Castilla, J. et al.: Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The hepatitis/HIV Spanish Study Group. Am. J. Gastroenterol, 1997, 92 , 1130–1134.

    Castilla J. , 'Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The hepatitis/HIV Spanish Study Group ' (1997 ) 92 Am. J. Gastroenterol : 1130 -1134.

    • Search Google Scholar
  • Sanchez-Quijano, A., Andreu, J., Gavilan, F., et al.: Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired hepatitis C. Eur. J. Clin. Microbiol. Infect. Dis., 1995, 14 , 949–953.

    Gavilan F. , 'Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired hepatitis C ' (1995 ) 14 Eur. J. Clin. Microbiol. Infect. Dis. : 949 -953.

    • Search Google Scholar
  • Thomas, D. L.: Hepatitis C and human immunodeficiency virus infection. Hepatology, 2002, 36 , S201–S209.

    Thomas D. L. , 'Hepatitis C and human immunodeficiency virus infection ' (2002 ) 36 Hepatology : S201 -S209.

    • Search Google Scholar
  • Soriano, V., Sulkowski, M., Bergin, C. et al.: Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV-HCV International Panel. AIDS, 2002, 16 , 813–828.

    Bergin C. , 'Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV-HCV International Panel ' (2002 ) 16 AIDS : 813 -828.

    • Search Google Scholar
  • Sherman, K. E., Rouster, S. D., Chung, R. T., Rajicic, N.: Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a crosssectional analysis of the US adult AIDS Clinical Trial Group. Clin. Infect. Dis., 2002, 6 , 831–837.

    Rajicic N. , 'Hepatitis C virus prevalence among patients infected with human immunodeficiency virus: a crosssectional analysis of the US adult AIDS Clinical Trial Group ' (2002 ) 6 Clin. Infect. Dis. : 831 -837.

    • Search Google Scholar
  • Mendes-Correa, M. C., Barone, A. A., Guastini, C.: Hepatitis C virus sero-prevalence and risk factors among patients with HIV infection. Rev. Inst. Trop., Sao Paulo, 2001, 1 , 15–19.

    Guastini C. , 'Hepatitis C virus sero-prevalence and risk factors among patients with HIV infection ' (2001 ) 1 Rev. Inst. Trop., Sao Paulo : 15 -19.

    • Search Google Scholar
  • Tankhiwale, S. S., Khadase, R. K., Jalgoankar, S. V.: Seroprevalence of anti-HCV and hepatitis B surface antigen in HIV infected patients. Indian J. Med. Microbiol., 2003, 21 , 268–270.

    Jalgoankar S. V. , 'Seroprevalence of anti-HCV and hepatitis B surface antigen in HIV infected patients ' (2003 ) 21 Indian J. Med. Microbiol. : 268 -270.

    • Search Google Scholar
  • Agwale, S. M., Tanimoto, L., Womack, C., Odama, L., Leung, K., Duey, D. et al.: Prevalence of HCV co-infection in HIV-infected individuals in Nigeria and characterization of HCV genotypes. J. Clin. Virol., 2004, 31 (Suppl. 1) , S3–S6.

    Duey D. , 'Prevalence of HCV co-infection in HIV-infected individuals in Nigeria and characterization of HCV genotypes ' (2004 ) 31 J. Clin. Virol. : S3 -S6.

    • Search Google Scholar
  • Ranger, S., Weinbreck, P., Loustaud, V. et al.: Seroprevalence of hepatitis C virus antibodies in HIV European seropositive patients. Int. Conf. AIDS, 1990, 6 , 235. Abstract.

    Loustaud V. , 'Seroprevalence of hepatitis C virus antibodies in HIV European seropositive patients ' (1990 ) 6 Int. Conf. AIDS : 235 -.

    • Search Google Scholar
  • Taiwo, B.: General HIV Medicine. Gastrointestinal system and HIV (chapter 6). The Floating Gallery, United States of America. 2004, 94–124.

  • McGovern, B. L. M., Golan, Y., Lawton, A. et al.: Absolute CD4 T cell subsets are decreased in HIV seronegative patients with cirrhosis. Hepatology, 2003, 38 , 429A.

    Lawton A. , 'Absolute CD4 T cell subsets are decreased in HIV seronegative patients with cirrhosis ' (2003 ) 38 Hepatology : 429A -.

    • Search Google Scholar
  • Woittas, R. P., Rockstroth, J. K., Beier, I. et al.: Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus co-infected patients. AIDS, 1999, 13 , 1313–1322.

    Beier I. , 'Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus co-infected patients ' (1999 ) 13 AIDS : 1313 -1322.

    • Search Google Scholar
  • Thomas, D. L., Shih, J. W., Alter, H. J. et al.: Effect of human immunodeficiency virus on hepatitis C virus infection among injection drug users. J. Infect. Dis., 1996, 174 , 690–695.

    Alter H. J. , 'Effect of human immunodeficiency virus on hepatitis C virus infection among injection drug users ' (1996 ) 174 J. Infect. Dis. : 690 -695.

    • Search Google Scholar
  • Hayashi, P. H., Flynn, N., McCurdy, S. A. et al.: Prevalence of hepatitis C virus antibodies among patients infected with human immunodeficiency virus. J. Med. Virol., 1991, 33 , 177–180.

    McCurdy S. A. , 'Prevalence of hepatitis C virus antibodies among patients infected with human immunodeficiency virus ' (1991 ) 33 J. Med. Virol. : 177 -180.

    • Search Google Scholar
  • McHutchison, J. G., Polito, A., Person, J. L. et al.: Assessment of hepatitis C antibody tests in homosexual men with hyperglobulinaemia. J. Infect. Dis., 1991, 164 , 217–218.

    Person J. L. , 'Assessment of hepatitis C antibody tests in homosexual men with hyperglobulinaemia ' (1991 ) 164 J. Infect. Dis. : 217 -218.

    • Search Google Scholar
  • 1999 USPHS/IDSA guidelines: for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. U. S. Public Health Service (USPHS) and Infectious Diseases Society of America (IDSA). MMWR Recomm. Rep., 1999, 48 , 1–59, 61–66.