Authors:
Judit Várkonyi Semmelweis University 3rd Department of Internal Medicine Kútvölgyi út 4 H-1125 Budapest Hungary

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Judit Jánosy National Medical Center Budapest Hungary

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László Gopcsa National Medical Center Budapest Hungary

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Tamás Masszi National Medical Center Budapest Hungary

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Júlia Tamáska National Medical Center Budapest Hungary

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Judit Csomor Semmelweis Unversity Institute of Pathology and Experimental Cancer Research Budapest Hungary

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András Matolcsy Semmelweis Unversity Institute of Pathology and Experimental Cancer Research Budapest Hungary

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Gábor Tarkovács Semmelweis University 3rd Department of Internal Medicine Kútvölgyi út 4 H-1125 Budapest Hungary

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Júlia Schönléber Semmelweis Unversity Institute of Pathology and Experimental Cancer Research Budapest Hungary

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Ferenc Kolozsváry Central Military Hospital Budapest Hungary

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It has long been believed that the coexistence of myelo- and lymphopoietic malignancies may develop as treatment-related complications. However, there are reports on the coincidence of lymphoid and non-lymphoid haemopoietic disorders, unrelated to therapy as well. Authors present 8 more examples for the concomitant development of myelodysplasia with multiple myeloma or monoclonal gammopathy. For such cases several explanations have been proposed that are also briefly reviewed.

  • Mufti, G. J., Hamblin, T. J., Clein, G. P., Race, C.: Coexistent myelodysplasia and plasma cell neoplasia. Br. J. Haematol., 1983, 93 , 53.

    Race C. , 'Coexistent myelodysplasia and plasma cell neoplasia ' (1983 ) 93 Br. J. Haematol. : 53 -.

    • Search Google Scholar
  • Coppelstone, J. A., Manoharan, A., Catovsky, D., Clein, P., Traub, N. E., Costello, C., O’Brien, M., Boralessa, H., Galton, D. G.: Simultaneous or spontaneous occurrence of lymphoid and myeloproliferative disorders. A report of four cases. Br. J. Haematol., 1981, 48 , 111.

    Galton D. G. , 'Simultaneous or spontaneous occurrence of lymphoid and myeloproliferative disorders. A report of four cases ' (1981 ) 48 Br. J. Haematol. : 111 -.

    • Search Google Scholar
  • Mori, M., Abe, T., Takei, T., Shibata, K.: The significance of myelodysplasia in untreated patients with multiple myeloma. Rinsho-Ketsueki, 1992, 33 , 662–665.

    Shibata K. , 'The significance of myelodysplasia in untreated patients with multiple myeloma ' (1992 ) 33 Rinsho-Ketsueki : 662 -665 .

    • Search Google Scholar
  • Sokol, R. J., Hewitt, S., Booker, D. J.: Erythrocyte autoantibodies, autoimmune haemolysis, and myelodysplastic syndromes. J. Clin. Pathol., 1989, 42 , 1088–1091.

    Booker D. J. , 'Erythrocyte autoantibodies, autoimmune haemolysis, and myelodysplastic syndromes ' (1989 ) 42 J. Clin. Pathol. : 1088 -1091 .

    • Search Google Scholar
  • Várkonyi, J., Jakab, L., Zalatnay, A., Nagy, P., Vámos, R., Szombathy, T.: Polychondritis terminating in eosinophilic leukemia. Pathol. Oncol. Res., 1997, 3 , 135–138.

    Szombathy T. , 'Polychondritis terminating in eosinophilic leukemia ' (1997 ) 3 Pathol. Oncol. Res. : 135 -138 .

    • Search Google Scholar
  • Coppelstone, J. A., Mufti, G. J., Hamblin, T. J., Oscier, D. G.: Immunological abnormalities in myelodysplastic syndromes. II. Coexistent lymphoid or plasma cell neoplasms: a report of 20 cases unrelated to chemotherapy. Br. J. Haematol., 1986, 63 , 149–159.

    Oscier D. G. , 'Immunological abnormalities in myelodysplastic syndromes. II. Coexistent lymphoid or plasma cell neoplasms: a report of 20 cases unrelated to chemotherapy ' (1986 ) 63 Br. J. Haematol. : 149 -159 .

    • Search Google Scholar
  • Sefer, D., Marisavljevic, D., Bogdanovic, A., Andrejevic, S., Boskovic, D., Suvajdid, N., Colovic, M.: Circulating Interleukin-6 (IL-6) in patients with myelodysplastic syndromes. Leukemia Res., 1999, 23 , 78.

    Colovic M. , 'Circulating Interleukin-6 (IL-6) in patients with myelodysplastic syndromes ' (1999 ) 23 Leukemia Res. : 78 -.

    • Search Google Scholar
  • Kiladijan, J. J., Bourgeouis, E., Lobe, I., Braun, T., Virentin, G., Bourhis, J. H., Fenaux, P., Chonaib, S., Caignard, A.: Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndrome. Leukemia, 2006, 20 , 463–470.

    Caignard A. , 'Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndrome ' (2006 ) 20 Leukemia : 463 -470 .

    • Search Google Scholar
  • Baumann, M., Libnoch, J., Hansen, R., Heckman, M. G., Hanson, G.: Concurrent myelodysplasia and lymphoproliferation. A disorder of the pluripotent stem cell? Q. J. Med., 1985, 55 , 199.

    Hanson G. , 'Concurrent myelodysplasia and lymphoproliferation. A disorder of the pluripotent stem cell? ' (1985 ) 55 Q. J. Med. : 199 -.

    • Search Google Scholar
  • Manoharan, A., Catovsky, D., Clein, P., Traub, N. E., Costello, C., O’Brien, M., Boralessa, H., Galton, D. G.: Simultaneous or spontaneous occurrence of lymphoid and myeloproliferative disorders. A report of four cases. Br. J. Haematol., 1981, 48 , 111.

    Galton D. G. , 'Simultaneous or spontaneous occurrence of lymphoid and myeloproliferative disorders. A report of four cases ' (1981 ) 48 Br. J. Haematol. : 111 -.

    • Search Google Scholar
  • Karp, J. E.: Molecular pathogenesis and targets for therapy in myelodysplastic syndrome (MDS) and MDS-related leukemias. Curr. Opin. Oncol., 1998, 10 , 3–9.

    Karp J. E. , 'Molecular pathogenesis and targets for therapy in myelodysplastic syndrome (MDS) and MDS-related leukemias ' (1998 ) 10 Curr. Opin. Oncol. : 3 -9 .

    • Search Google Scholar
  • Nilsson, L., Astrand-Grundstörm, I., Arvidsson, I., Jacobsson, B., Hellström-Lindberg, E., Hast, R., Jacobsen, E. W.: Isolation and characterization of hematopoietic progenitor/stem cells in 5q- deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood, 2000, 96 , 2012–2021.

    Jacobsen E. W. , 'Isolation and characterization of hematopoietic progenitor/stem cells in 5q- deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level ' (2000 ) 96 Blood : 2012 -2021 .

    • Search Google Scholar
  • Cortelezzi, A., Ibatici, A., Sarina, B., Motta, M., Cattaneo, C., Terruzzi, E., Maiolo, A. T.: Concurrent diagnosis of chronic lymphocytic leukemia and myelodysplastic syndromes (MDS): Demonstration of presence of different malignant clones by cytogenetics.; Blood, 1998, 92/10/ Suppl. 1, Abstr No. 4124.

  • Weh, H. J., Seeger, D., Junge, I., Hossfeld, D. K.: Trisomy 8 preceeding diagnosis of acute nonlymphocytic leukemia by 2 years in a patient with multiple myeloma without cytological evidence of myelodysplasia. Ann. Hematol., 1996, 72 , 81–82.

    Hossfeld D. K. , 'Trisomy 8 preceeding diagnosis of acute nonlymphocytic leukemia by 2 years in a patient with multiple myeloma without cytological evidence of myelodysplasia ' (1996 ) 72 Ann. Hematol. : 81 -82 .

    • Search Google Scholar
  • Dewald, G. W., Kyle, R. A., Hicks, G. A., Greipp, P. R.: The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis. Blood, 1985, 66 , 380–390.

    Greipp P. R. , 'The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis ' (1985 ) 66 Blood : 380 -390 .

    • Search Google Scholar
  • Várkonyi, J., Bajzik, E., Fazakas, A., Sipka, S., Karádi, I.: Short or long survival in multiple myeloma. A simple method for determining the prognosis. Pathol. Oncol. Res., 2007 (in press).

  • Várkonyi, J., Demeter, J., Tordai, A., Andrikovics, H.: The significance of the Hemochromatosis genetic variants in multiple myeloma in comparison to that of myelodysplastic syndrome. Ann. Hematol., 2006, 85 , 869–871.

    Andrikovics H. , 'The significance of the Hemochromatosis genetic variants in multiple myeloma in comparison to that of myelodysplastic syndrome ' (2006 ) 85 Ann. Hematol. : 869 -871 .

    • Search Google Scholar
  • Jacobson, J., Barlogie, B., Shaughnessy, J. et al.: MDS-type abnormalities with myeloma signature karyotype (MM-MDS). Only 13% 1-year survival despite tandem transplants. Br. J. Haematol., 2003, 122 , 430–440.

    Shaughnessy J. , 'MDS-type abnormalities with myeloma signature karyotype (MM-MDS). Only 13% 1-year survival despite tandem transplants ' (2003 ) 122 Br. J. Haematol. : 430 -440 .

    • Search Google Scholar
  • Gattermann, P., Gatterman, N., Retzlaff, S., Wang, Y.-L. et al.: Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia. Blood, 1997, 90 , 4961–4972.

    Wang Y.-L. , 'Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia ' (1997 ) 90 Blood : 4961 -4972 .

    • Search Google Scholar
  • Várkonyi, J., Tarkovács, G., Karádi, I., Andrikovics, H., Varga, F., Varga, F., Demeter, J., Tordai, A.: High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: The Budapest study on 50 patients. Acta Haematol., 2003, 109 , 64–67.

    Tordai A. , 'High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: The Budapest study on 50 patients ' (2003 ) 109 Acta Haematol. : 64 -67 .

    • Search Google Scholar
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Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)