Hungarian Medical Journal
Volume/Issue:
Volume 1: Issue 2
Serum Interleukin-10 Level in Patients with Chronic Hepatitis B Infection
Authors:
Fazal Karim Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Salimur Rahman Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Mobin Khan Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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AKM Khorshed Alam Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Nooruddin Ahmed Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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KMJ Zaki Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Mamun-Al-Mahtab Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Chitta Ranjan Debnath Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Pages:
241–250
Online Publication Date:
16 Jul 2007
Publication Date:
01 Jun 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/hmj.1.2007.2.11
Keywords:
chronic hepatitis B; interleukin-10
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Background/Aims: Preferential production of immunoregulatory cytokines may play an important role in the pathogenesis of chronic hepatitis B. Patients with chronic hepatitis B infection were evaluated to determine whether serum interleukin-10 (IL-10) levels were changed and whether the degree of these changes in serum levels correlated with HBV DNA levels, histologic activity index (HAI) or serum aminotransferase levels (ALT). Methodology: 15 patients diagnosed of chronic hepatitis B (wild type) with raised ALT, 15 inactive HBsAg carriers, 15 healthy people with resolved acute hepatitis B, and 15 healthy controls without any hepatitis marker positivity were included in the study. Serum IL-10 levels were measured. The associations between liver pathology, HBV DNA and ALT levels were assessed. Result: IL-10 is elevated more in chronic hepatitis B with positive HBeAg and raised ALT in comparison to asymptomatic carrier, resolved acute hepatitis B and control. Conclusions: IL-10 production is increased in chronic hepatitis B patients with HBeAg positivity and raised ALT as compared to other groups ( p < 0.01). No correlation between HBV DNA, HAI or ALT could be established through this study. However, as IL-10 is increased in chronic hepatitis B infection with HBeAg positivity, the HBe antigen may be responsible for the raised IL-10 levels.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
Volumes
per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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