Authors:
Fazal Karim Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Salimur Rahman Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Mobin Khan Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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AKM Khorshed Alam Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Nooruddin Ahmed Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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KMJ Zaki Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Mamun-Al-Mahtab Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Chitta Ranjan Debnath Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Background/Aims: Preferential production of immunoregulatory cytokines may play an important role in the pathogenesis of chronic hepatitis B. Patients with chronic hepatitis B infection were evaluated to determine whether serum interleukin-10 (IL-10) levels were changed and whether the degree of these changes in serum levels correlated with HBV DNA levels, histologic activity index (HAI) or serum aminotransferase levels (ALT). Methodology: 15 patients diagnosed of chronic hepatitis B (wild type) with raised ALT, 15 inactive HBsAg carriers, 15 healthy people with resolved acute hepatitis B, and 15 healthy controls without any hepatitis marker positivity were included in the study. Serum IL-10 levels were measured. The associations between liver pathology, HBV DNA and ALT levels were assessed. Result: IL-10 is elevated more in chronic hepatitis B with positive HBeAg and raised ALT in comparison to asymptomatic carrier, resolved acute hepatitis B and control. Conclusions: IL-10 production is increased in chronic hepatitis B patients with HBeAg positivity and raised ALT as compared to other groups ( p < 0.01). No correlation between HBV DNA, HAI or ALT could be established through this study. However, as IL-10 is increased in chronic hepatitis B infection with HBeAg positivity, the HBe antigen may be responsible for the raised IL-10 levels.

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Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)