Hungarian Medical Journal
Volume/Issue:
Volume 1: Issue 3
The Role of Fibroblasts in Normal, Repair and Pathological Processes
Authors:
Antal Salamon Markusovszky Teaching Hospital of County Vas Dept. of Traumatology, Reconstructive Surgery, Hand Surgery Király u. 11 H-9700 Szombathely Hungary

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and
Erzsébet Toldy

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Pages:
281–293
Online Publication Date:
27 Sep 2007
Publication Date:
01 Sep 2007
Article Category:
Research Article
DOI:
https://doi.org/10.1556/oh-hmj.2007.28164
Keywords:
fibroblast; growth factor; cytokine; extracellular matrix; collagen; integrin; fibronectin
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The fibroblast is counted as one of the important cells of the connective tissue. At the present time many phenotypes are known taking part in normal, repair and pathological processes, meanwhile cellular and molecular events occur, where fibroblasts play essential role. Among molecular factors, first of all integrins, growth factors, cytokines and matrix molecules are discussed. The aim of this work is to make known the morphological, biochemical and functional role of fibroblasts in addition to the physiological process, in wound repair and in such pathological processes as Dupuytren’s disease, rheumatoid arthritis, Graves’ ophthalmopathy and carcinogenesis. It became known that fibroblasts participate in dynamic interplay with other cells and with the extracellular matrix. The results of the new investigations clarify better the physiological and pathological processes of the tissue, at the same time give potential help to the therapy of some illnesses. The authors summarise on the basis of international literature and of their own investigations the most important data of the subject.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
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per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
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Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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