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  • 1 Markusovszky Teaching Hospital of County Vas Dept. of Traumatology, Reconstructive Surgery, Hand Surgery Király u. 11 H-9700 Szombathely Hungary
  • | 2 Markusovszky Teaching Hospital of County Vas Central Laboratory Szombathely Hungary
  • | 3 University of Pécs Department of Practical Diagnostic of Institute of Diagnostics and Management, Szombathely Szombathely Hungary
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The fibroblast is counted as one of the important cells of the connective tissue. At the present time many phenotypes are known taking part in normal, repair and pathological processes, meanwhile cellular and molecular events occur, where fibroblasts play essential role. Among molecular factors, first of all integrins, growth factors, cytokines and matrix molecules are discussed. The aim of this work is to make known the morphological, biochemical and functional role of fibroblasts in addition to the physiological process, in wound repair and in such pathological processes as Dupuytren’s disease, rheumatoid arthritis, Graves’ ophthalmopathy and carcinogenesis. It became known that fibroblasts participate in dynamic interplay with other cells and with the extracellular matrix. The results of the new investigations clarify better the physiological and pathological processes of the tissue, at the same time give potential help to the therapy of some illnesses. The authors summarise on the basis of international literature and of their own investigations the most important data of the subject.

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Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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