Hungarian Medical Journal
Volume/Issue:
Volume 2: Issue 1
Hepatitis E Virus is a Leading Cause for Decompensation of Liver in Cirrhotics: Experience from a Tertiary Centre in Bangladesh
Authors:
Mamun-Al-Mahtab Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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,
Salimur Rahman Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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, and
Mobin Khan Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Pages:
117–120
Online Publication Date:
14 Mar 2008
Publication Date:
01 Mar 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1556/hmj.2.2008.1.13
Keywords:
HEV; cirrhosis; decompensation
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Introduction: Liver cirrhosis is common in Bangladesh. There has been a rise in acute viral E hepatitis in Bangladesh after the 2004 flood. At that time most of the country was under water for more than a month leading to sewerage contamination of water supply. The aim of this study was to assess the role of HEV infection in causing decompensation of cirrhosis. Materials and Methods: In this retrospective study, 69 patients with evidence of cirrhosis were included. They presented between January 2005 to January 2006 with features of decompensation for the first time. Anti-HEV IgM and anti-HAV IgM were tested and history of upper GI haemorrhage, drug and alcohol intake recorded. Results: Anti-HEV IgM was positive in 21.7% (15/69) patients. 4.3% (3/69) had history of upper GI haemorrhage and 4.3% (3/69) history of alcohol intake or diuretic overdose or anti-tuberculotic drugs. None tested positive for anti-HAV IgM. No cause for decompensation was found in others. It is likely that decompensation in these patients resulted from progression of the cirrhosis. Conclusion: Acute HEV infection is a leading cause of decompensation of liver cirrhosis in Bangladesh. Sewerage contamination of water supply following flood contributed to the higher incidence of HEV infections.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
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per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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