Hungarian Medical Journal
Volume/Issue:
Volume 2: Issue 1
Evaluation of Hepatoprotective Activity of Broccoli ‘Brassica oleracea’ in Rats
Author:
Tawfeq Al-Howiriny College of Pharmacy, King Saud University Department of Pharmacognosy P. O. Box 2457 Riyadh 11451 Saudi Arabia

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Pages:
145–156
Online Publication Date:
14 Mar 2008
Publication Date:
01 Mar 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1556/hmj.2.2008.1.16
Keywords:
broccoli; phytochemistry; hepatoprotection; carbon tetrachloride
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The hepatoprotective and antioxidant effect of broccoli “Brassica oleracea L.” (aqueous extract of freeze dried powder) on liver injury induced by carbon tetrachloride (CCl 4 ) was investigated. Wistar albino rats weighing 180–200 g were administered a single dose of CCl 4 , GOT, GPT, ALP, GGT and bilirubin were estimated in serum. Non-protein sulfhydryl (NP-SH) and malondialdehyde (MDA) were also estimated in liver tissue. CCl 4 induced hepatotoxicity in all treated animals was evident by elevated serum GOT, GPT, ALP, GGT and bilirubin levels and simultaneous fall in NP-SH and increased MDA activities in liver tissue. The broccoli extract at the doses of 150 and 300 mg/kg produced significant hepatoprotection by decreasing the activity of serum enzymes, bilirubin, while it significantly increased the levels of NP-SH and decreased MDA of liver tissue. Histopathological observations of the liver also showed the protective effect of broccoli in CCl 4 -induced hepatic injury in rats. The obtained results suggest that broccoli possesses hepatoprotective capacity and may have potential therapeutic value in the treatment of some liver disorders probably by its antioxidative effects on hepatocytes, due to flavonoids and sulfurated compounds.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
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Year of
Foundation		 2007
Publication
Programme		 ceased
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Publisher Akadémiai Kiadó
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Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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