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  • 1 Medical Faculty, Semmelweis University 2nd Department of Medicine Szentkirályi u. 46 H-1088 Budapest Hungary
  • | 2 Semmelweis University Molecular Medicine Research Group Budapest Hungary
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In chronic liver diseases with inflammatory reactions (chronic viral hepatitis, alcoholic liver disease, non-alcoholic steatohepatitis, autoimmune hepatitis, drug- and chemical-induced hepatitis, Wilson disease, and haemochromatosis), oxidative stress, the cellular damage caused by free radicals, is an important part of the pathogenesis beside the aetiological factors. In this paper the development of free radicals and their physiological role are demonstrated. The factors that influence the equilibrium between free radicals and antioxidant systems, as well as the pathological effects caused by oxidative stress in biological systems are discussed. The authors demonstrate the free radical processes as key factors in alcoholic liver disease and non-alcoholic steatohepatitis, furthermore the possible treatment modalities in the inhibition of these alterations. They also call the attention to the free radical processes in chronic viral hepatitis and autoimmune hepatitis. Independently of the aetiological factor or together with it, the oxidative stress can enhance the progression of chronic inflammatory liver diseases, and therefore, in addition to therapies based on the aetiological factors, the use of antioxidants may also be justified in the treatment of chronic liver diseases.

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Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
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per Year
 
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per Year
 
Publisher Akadémiai Kiadó
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Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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