Background: Recently several estimated GFR (eGFR) formulae have been developed and new creatinine methods were introduced to compensate for the effect of “pseudocreatinines”. These methods resulted in lower creatinine and higher eGFRs. Methods: Original 6-v MDRD (Modification of Diet in Renal Disease), 4-v MDRD, Cockcroft-Gault (C-G), Quadratic and the new MDRD-175 formulae were tested in 31 patients. The eGFR based on both Jaffe and compensated-Jaffe creatinine were compared to Tc-99m labeled diethylenetriamine pentaacetic acid clearance (DTPA-GFR). Results: All eGFRs correlated with DTPA-GFR (range 16–104 mL/min/1.73 m 2 ). Original MDRD and C-G showed high correlation coefficients (0.88 and 0.78), but original and 4-v MDRD tended to overestimate GFR below 60 ml/min/1.73 m 2 and underestimate it above 60 mL/min/1.73 m 2 . Using compensated-Jaffe creatinine reduced the underestimation of the original MDRD, but resulted in overestimation of the 4-v MDRD, C-G and quadratic GFR. With the exception of the original MDRD, the correlations between eGFRs and DTPA-GFR were higher using Jaffe method. Applying the new MDRD-175 with compensated Jaffe creatinine resulted in lower bias of GFR. Conclusion: Harmonization of creatinine methods is necessary because it has significant effect on the eGFR. The IDMS-calibrated creatinine in the new MDRD-175 formula provides reliable eGFR in kidney disease.
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