Hungarian Medical Journal
Volume/Issue:
Volume 2: Issue 2
The Efficacy of Indapamide in Different Cardiovascular Outcomes; Meta-Analysis
Authors:
Valentin Brodszky Corvinus University of Budapest Health Economics and Health Technology Assessment Research Centre Fővám tér 8 H-1089 Budapest Hungary

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Viktor Nagy Faculty of Medicine, Semmelweis University 2nd Department of Internal Medicine Budapest Hungary

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Csaba Farsang Faculty of Medicine, Semmelweis University 1st Department of Internal Medicine Budapest Hungary

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Krisztián Kárpáti Corvinus University of Budapest Health Economics and Health Technology Assessment Research Centre Fővám tér 8 H-1089 Budapest Hungary

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László Gulácsi Corvinus University of Budapest Health Economics and Health Technology Assessment Research Centre Fővám tér 8 H-1089 Budapest Hungary

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Pages:
181–191
Online Publication Date:
13 Jun 2008
Publication Date:
01 Jun 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1556/hmj.2.2008.2.28046
Keywords:
cardiovascular disease; hypertension; indapamide; meta-analysis
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First-line antihypertensive treatment’s drugs have to be able to decrease the cardiovascular morbidity and mortality. This kind of efficacy of thiazide-type diuretics has been published earlier in several studies. The efficacy of indapamide was investigated in several studies, but there is no analysis which is including all of the indapamide-studies. Objective: We conducted a meta-analysis of all relevant randomized-controlled-trials with indapamide. Efficacy of indapamide was analyzed in different cardiovascular and safety outcomes. Methods: We searched the MEDLINE database 1995–2006 for indapamide-trials. Only double-blind, parallel-group design trials were involved. Both the fixed effect model and the random effect model were used for data synthesis, results were probed with Mantel–Hanzel test and inverse variance test. Results: Data were combined from 9 trials that included 10,108 patients. Indapamide treatment of 48 patients with a history of stroke prevents one stroke (NNT = 47.8 95% CI: 29.6–126.6). Data from 5 trials including 7,085 patients show that indapamide is superior to placebo in reducing blood pressure, the differences are: 7.28 mm Hg (95% CI: 6.37–8.19) in systolic blood pressure and 3.50 mm Hg (95% CI: 2.99–4.01) in diastolic blood pressure. Data from 5 trials including 2,856 patients show that indapamide is superior to active controls in reducing systolic blood pressure, the difference is significant: 1.30 mm Hg (95% CI: 0.28–2.31). The difference in diastolic blood pressure was not significant. Data of 505 patients show that indapamide reduced left ventricular mass index significantly more than enalapril 20 mg, the difference is 6.50 g/m 2 (95% CI: 0.81–12.19). Data of 6,206 patients show that the frequency of adverse drug reaction is similar in the indapamide and placebo groups (RR = 0.97 95% CI: 0.76–1.22). Conclusions: Indapamide is efficacious in the prevention of further stroke, reduces effectively the blood pressure and the left ventricular mass index. Indapamide treatment is well tolerated.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
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per Year		  
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per Year		  
Publisher Akadémiai Kiadó
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Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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