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  • 1 Jos University Teaching Hospital Department of Medicine PMB 2076 Jos Nigeria
  • 2 University College Hospital Department of Medicine Ibadan Nigeria
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Background: Cognitive dysfunction is a common source of morbidity and mortality, usually observed in late stages of diabetes complications. Dementia is one of the commonest and most disabling late life mental disorders. The fact that data are scanty in the tropic cannot be overemphasized. There is a need to describe the association of cognitive dysfunction among our diabetics and its attendant risks such as duration of DM, age of patient, presence of hypertension and glycaemic control. Methods: a sample size of 180 patients was obtained with 120 diabetic subjects and 60 non-diabetics as controls. The mini-mental state examination (MMSE) was used to grade the severity of cognitive states. Result: twenty-six (21.7%) of the diabetic subjects had cognitive dysfunction with a score of less than twenty-four based on the mini-mental state examination (MMSE) while 6 (10.0%) of the controls had dementia. Conclusion: This study clearly shows that in a clinic setting, diabetes is associated with a greater trend toward impairments of cognitive function than in the non-diabetic population.

  • Coker, D. O., Oheari, J. U., Lawal, R. D. et al.: Specific psychiatric morbidity among diabetics. East Africa Med. J., 2000, 77 , 42–43.

    Lawal R. D. , 'Specific psychiatric morbidity among diabetics ' (2000 ) 77 East Africa Med. J. : 42 -43.

    • Search Google Scholar
  • Strachan, M. W., Deavy, I. J., Ewing, A. U. et al.: Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabet. Care, 1997, 20 , 438–445.

    Ewing A. U. , 'Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies ' (1997 ) 20 Diabet. Care : 438 -445.

    • Search Google Scholar
  • Lincoln, N. B., Faleiro, R. M., Kelly, C. et al.: Effect of long-term glycemic control on cognitive function. Diabet. Care, 1996, 19 , 656–658.

    Kelly C. , 'Effect of long-term glycemic control on cognitive function ' (1996 ) 19 Diabet. Care : 656 -658.

    • Search Google Scholar
  • Alberti, K. G. M. M., Zimmet, P. Z.: WHO Consultation. Definitions, diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet. Med., 1998, 14 , 539–553.

    Zimmet P. Z. , 'WHO Consultation. Definitions, diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation ' (1998 ) 14 Diabet. Med. : 539 -553.

    • Search Google Scholar
  • Roman, G. C., Tastemichi, T. K., Orgogozo, J. M. et al.: Vascular dementia, diagnostic criteria for research studies. Report of the NINDS–AIREN International Workshop. Neurology, 1993, 43 , 250–260.

    Orgogozo J. M. , 'Vascular dementia, diagnostic criteria for research studies. Report of the NINDS–AIREN International Workshop ' (1993 ) 43 Neurology : 250 -260.

    • Search Google Scholar
  • Folstein, M. F., Folstein, S. F., McHugh, P. R.: Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatry Res., 1975, 12 , 189–198.

    McHugh P. R. , 'Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician ' (1975 ) 12 J. Psychiatry Res. : 189 -198.

    • Search Google Scholar
  • Strachan, M. W., Deavy, I. J., Ewing, A. U. et al.: Is Type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabet. Care, 1997, 20 , 438–445.

    Ewing A. U. , 'Is Type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies ' (1997 ) 20 Diabet. Care : 438 -445.

    • Search Google Scholar
  • Imam, I., Onifade, A., Ogunniyi, A. et al.: Performance of normal Nigerian students on the mini-mental state examination. Niger. J. Med., 2003, 12 , 126–129.

    Ogunniyi A. , 'Performance of normal Nigerian students on the mini-mental state examination ' (2003 ) 12 Niger. J. Med. : 126 -129.

    • Search Google Scholar
  • Harati, Y.: Diabetes and the nervous system. Endocrinol. Metab. Clin. North Am., 1996, 25 , 325–359.

    Harati Y. , 'Diabetes and the nervous system ' (1996 ) 25 Endocrinol. Metab. Clin. North Am. : 325 -359.

    • Search Google Scholar
  • Clark, C. M., Lee, D. A. et al.: Prevention and treatment of the complications of diabetes mellitus. N. Engl. Med. J., 1995, 332 , 1210–1216.

    Lee D. A. , 'Prevention and treatment of the complications of diabetes mellitus ' (1995 ) 332 N. Engl. Med. J. : 1210 -1216.

    • Search Google Scholar
  • The National Expert Committee on Non-communicable Diseases (NCD) in Nigeria. Final Report of a National Survey. 1997, series 4, 64–96.