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  • 1 Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh
  • 2 Bangabandhu Sheikh Mujib Medical University Department of Pathology Dhaka Bangladesh
  • 3 Dhaka Mahanagar Hospital Dhaka Bangladesh
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Autoimmune hepatitis is defined as chronic liver disease of unknown aetiology with aberrant autoreactivity and genetic predisposition. It is characterized by female predominance, circulating auto-antibodies, hypergammaglobulinaemia and association with HLA DR3 and HLA DR4 [1]. Differential diagnosis includes chronic viral hepatitis, drug induced hepatitis and alcohol. We present two patients with autoimmune hepatitis representing the two extremes of hepatic involvement in this condition. The first patient is a young lady who was diagnosed with autoimmune chronic hepatitis. The second patient, on the other hand, is an elderly gentleman who presented to us with autoimmune hepatitis-related decompensated cirrhosis of liver.

  • Obermayer-Straub, P., Strassburg, C. P., Manns, M. P.: Autoimmune hepatitis. J. Hepatol., 2000, 32 , 181–197.

    Manns M. P. , 'Autoimmune hepatitis ' (2000 ) 32 J. Hepatol. : 181 -197.

  • Waldenstrom, J.: Leber, Blutproteine und Nahrungsweiss. Stoffwechs. Krh., Sonderband: XV, p. 8. Tagung, Bad Kissingen, 1950.

  • Hodges, S., Loboyeo, A., Donaldson, P. et al.: Autoimmune chronic active hepatitis in a family. Gut, 1991, 32 , 299–302.

    Donaldson P. , 'Autoimmune chronic active hepatitis in a family ' (1991 ) 32 Gut : 299 -302.

  • Homberg, J. C., Abuaf, N., Bernard, O. et al.: Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of ‘autoimmune’ hepatitis. Hepatology, 1987, 7 , 1333–1339.

    Bernard O. , 'Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of ‘autoimmune’ hepatitis ' (1987 ) 7 Hepatology : 1333 -1339.

    • Search Google Scholar
  • Wies, I., Brunner, S., Henninger, J. et al.: Identification of target antigen for SLA/LP autoantibodes in autoimmune hepatitis. Lancet, 2000, 355 , 1510.

    Henninger J. , 'Identification of target antigen for SLA/LP autoantibodes in autoimmune hepatitis ' (2000 ) 355 Lancet : 1510 -.

    • Search Google Scholar
  • Read, A. E., Sherlock, S., Harrison, C. V.: Active ‘juvenile’ cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy. Gut, 1963, 4 , 378–393.

    Harrison C. V. , 'Active ‘juvenile’ cirrhosis considered as part of a systemic disease and the effect of corticosteroid therapy ' (1963 ) 4 Gut : 378 -393.

    • Search Google Scholar
  • Sherlock, S., Dooley, J.: Diseases of the Liver and Biliary System. 11th Edition, 2002, Blackwell Science.

  • Knodell, R. G., Ishak, K. G., Black, W. C. et al.: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology, 1981, 4 , 431.

    Black W. C. , 'Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis ' (1981 ) 4 Hepatology : 431 -.

    • Search Google Scholar
  • Johnson, P. J., McFarlane, I. G., Williams, R.: Azathioprine for long-term maintenance of remission in autoimmune hepatitis. N. Eng. J. Med., 1995, 333 , 958.

    Williams R. , 'Azathioprine for long-term maintenance of remission in autoimmune hepatitis ' (1995 ) 333 N. Eng. J. Med. : 958 -.

    • Search Google Scholar
  • Hayams, J. S., Ballows, M., Leichtner, A. M.: Cyclosporin treatment of autoimmune chronic active hepatitis. Gastroenterology, 1987, 93 , 890.

    Leichtner A. M. , 'Cyclosporin treatment of autoimmune chronic active hepatitis ' (1987 ) 93 Gastroenterology : 890 -.

    • Search Google Scholar
  • Devlin, J., Donaldson, P., Portman, B. et al.: Recurrence of autoimmune hepatitis following liver transplantation. Liver Transplant. Sur., 1995, 1 , 162.

    Portman B. , 'Recurrence of autoimmune hepatitis following liver transplantation ' (1995 ) 1 Liver Transplant. Sur. : 162 -.

    • Search Google Scholar