The hypophysiotropic corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons have important role in the regulation of energy homeostasis. The studies of this PhD work, carried out on rats, focused on the innervation and regulation of these neurosecretory neurons by specific neuron populations involved in the processing of metabolic signals.
Wittmann, G., Liposits, Z., Lechan, R. M. et al.: Medullary adrenergic neurons contribute to the neuropeptide Y-ergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the rat. Neurosci. Lett., 2002, 324 , 69–73.
Lechan R. M. , 'Medullary adrenergic neurons contribute to the neuropeptide Y-ergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the rat ' (2002 ) 324 Neurosci. Lett. : 69 -73 .
Fekete, C., Wittmann, G., Liposits, Z. et al.: Origin of cocaine- and amphetamine-regulated transcript (CART) – immunoreactive innervation of the hypothalamic paraventricular nucleus. J. Comp. Neurol., 2004, 469 , 340–350.
Liposits Z. , 'Origin of cocaine- and amphetamine-regulated transcript (CART) – immunoreactive innervation of the hypothalamic paraventricular nucleus ' (2004 ) 469 J. Comp. Neurol. : 340 -350 .
Sarkar, S., Wittmann, G., Fekete, C. et al.: Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons in the hypothalamic paraventricular nucleus. Brain Res., 2004, 999 , 181–192.
Fekete C. , 'Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons in the hypothalamic paraventricular nucleus ' (2004 ) 999 Brain Res. : 181 -192 .
Wittmann, G., Sarkar, S., Hrabovszky, E. et al.: Galanin- but not galanin-like peptide-containing axon terminals innervate hypophysiotropic TRH-synthesizing neurons in the hypothalamic paraventricular nucleus. Brain Res., 2004, 1002 , 43–50.
Hrabovszky E. , 'Galanin- but not galanin-like peptide-containing axon terminals innervate hypophysiotropic TRH-synthesizing neurons in the hypothalamic paraventricular nucleus ' (2004 ) 1002 Brain Res. : 43 -50 .
Wittmann, G., Liposits, Z., Lechan, R. M. et al.: Medullary adrenergic neurons contribute to the cocaine- and amphetamine-regulated transcript-immunoreactive innervation of thyrotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus. Brain Res., 2004, 1006 , 1–7.
Lechan R. M. , 'Medullary adrenergic neurons contribute to the cocaine- and amphetamine-regulated transcript-immunoreactive innervation of thyrotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus ' (2004 ) 1006 Brain Res. : 1 -7 .
Wittmann, G., Liposits, Z., Lechan, R. M. et al.: Origin of cocaine- and amphetamine-regulated transcript-containing axons innervating hypophysiotropic corticotropin-releasing hormone-synthesizing neurons in the rat. Endocrinology, 2005, 146 , 2985–2991.
Lechan R. M. , 'Origin of cocaine- and amphetamine-regulated transcript-containing axons innervating hypophysiotropic corticotropin-releasing hormone-synthesizing neurons in the rat ' (2005 ) 146 Endocrinology : 2985 -2991 .
Fekete, C., Wittmann, G., Liposits, Z. et al.: GABA-ergic innervation of thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. Brain Res., 2002, 957 , 251–258.
Liposits Z. , 'GABA-ergic innervation of thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat ' (2002 ) 957 Brain Res. : 251 -258 .
Hrabovszky, E., Wittmann, G., Túri, G. F. et al.: Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2. Endocrinology, 2005, 146 , 341–347.
Túri G. F. , 'Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2 ' (2005 ) 146 Endocrinology : 341 -347 .
Wittmann, G., Lechan, R. M., Liposits, Z. et al.: Glutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. Brain Res., 2005, 1039 , 53–62.
Liposits Z. , 'Glutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat ' (2005 ) 1039 Brain Res. : 53 -62 .
Menyhért, J., Wittmann, G., Hrabovszky, E. et al.: Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus. Brain Res., 2006, 1076 , 101–105.
Hrabovszky E. , 'Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus ' (2006 ) 1076 Brain Res. : 101 -105 .
Hrabovszky, E., Kalló, I., Túri, G. F. et al.: Expression of vesicular glutamate transporter-2 in gonadotrope and thyrotrope cells of the rat pituitary. Regulation by estrogen and thyroid hormone status. Endocrinology, 2006, 147 , 3818–3825.
Túri G. F. , 'Expression of vesicular glutamate transporter-2 in gonadotrope and thyrotrope cells of the rat pituitary. Regulation by estrogen and thyroid hormone status ' (2006 ) 147 Endocrinology : 3818 -3825 .
Menyhért, J., Wittmann, G., Hrabovszky, E. et al.: Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus. Brain Res., 2006, 1125 , 31–36.
Hrabovszky E. , 'Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus ' (2006 ) 1125 Brain Res. : 31 -36 .
Wittmann, G., Deli, L., Kalló, I. et al.: Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J. Comp. Neurol., 2007, 503 , 270–9.
Kalló I. , 'Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus ' (2007 ) 503 J. Comp. Neurol. : 270 -9 .
Menyhért, J., Wittmann, G., Lechan, R. M. et al.: Cocaine- and amphetamine regulated transcript (CART) is colocalized with the orexigenic NPY and AGRP and absent from the anorexigenic {alpha}-MSH neurons in the infundibular nucleus of the human hypothalamus. Endocrinology, 2007 May 24 [Epub ahead of print].