Hungarian Medical Journal
Volume/Issue:
Volume 2: Issue 4
Fatty Liver in Childhood
Authors:
Ádám Eiszrich Municipal Children’s Hospital Madarász V. u. 22–24 H-1131 Budapest Hungary

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and
János Fehér Semmelweis University Medical School 2nd Department of Medicine Budapest Hungary

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Pages:
519–531
Online Publication Date:
01 Dec 2008
Publication Date:
01 Dec 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1556/hmj.2.2008.28270
Keywords:
hepatocyte; fatty liver; NASH; NAFLD
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In the background of hepatic steatosis there is an imbalance between the processes of the hepatocytes’ lipid uptake and lipid elimination, thus overproduction results in the accumulation of excess triglycerides in the cells of the liver. Normally about 5% of the cells contain triglyceride; in steatosis this may exceed 50%. Under 50% the condition is called fatty infiltration, and over 50% it is called fatty liver. In mild forms this does not necessarily lead to disorders in cell functions, but in more severe forms it does; it often precedes the death of the cells. Fatty liver can be considered a pathologic condition which makes the liver more susceptible to other toxic influences. It is not a genuine disease; in most cases it is associated with a noxious state or other pathologic process. By itself, to a certain grade of severity (the appearance of fibrosis), it represents a reversible damage; upon cessation of the underlying cause the liver clears its excess triglyceride content. The treatment is to be aimed at the underlying process; up to now there is no known specific medicine that could reduce the fat accumulated in the hepatocytes.

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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
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Publisher Akadémiai Kiadó
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Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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