Hungarian Medical Journal
Volume/Issue:
Volume 2: Issue 4
Genotypes of HCV in Bangladesh: Experience from a Tertiary Centre
Authors:
Mamun-Al-Mahtab Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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,
Salimur Rahman Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Mobin Khan Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Fazal Karim Dhaka Mohanagar Hospital Dhaka Bangladesh

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Niaz M. Sharif National Healthcare Group Singapore

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, and
Ananta Shrestha Bangabandhu Sheikh Mujib Medical University Department of Hepatology Dhaka Bangladesh

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Pages:
577–581
Online Publication Date:
01 Dec 2008
Publication Date:
01 Dec 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1556/hmj.2.2008.4.9
Keywords:
hepatitis C virus; genotype; Bangladesh
Restricted access

Introduction: Hepatitis C virus (HCV) is a leading cause of chronic liver disease worldwide including Bangladesh. Approximately 0.84% of our population is infected with HCV. Genotypes of HCV are important in the determination of treatment duration and in predicting the response to treatment in HCV infection. Methodology: 61 consecutive patients who presented to us with chronic hepatitis C (CHC) and who could afford treatment and having no features of decompensation were included in the study. Results: Of the 61 study subjects, 46 were males and 15 females. They were between 12 and 70 years of age. Of them 41% had genotype 3, 31% had mixed genotypes 3 + 4 and 21% had genotype 1. Patients also had genotypes 2, 4, 5 and mixed genotypes 5 + 6, the figure being 1.6% in each case. Conclusion: Genotype 3 is the commonest HCV genotype in Bangladesh, while we also have a high prevalence of mixed HCV genotypes.

  • Dusheiko, G., Schmilovitz-Weiss, H., Brown, D. et al.: Hepatitis C virus genotypes – an investigation of type-specific differences in geographic origin and disease. Hepatology, 1994, 19 , 13–18.

    Brown D. , 'Hepatitis C virus genotypes – an investigation of type-specific differences in geographic origin and disease ' (1994 ) 19 Hepatology : 13 -18 .

    • Search Google Scholar

  • Simmonds, P., Holmes, E. C., Cha, T. A. et al.: Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J. Gen. Virol., 1993, 74 , 2391–2399.

    Cha T. A. , 'Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region ' (1993 ) 74 J. Gen. Virol. : 2391 -2399 .

    • Search Google Scholar

  • Dusheiko, G. M., Simmonds, P.: Sequence variability of hepatitis C virus and its clinical relevance. J. Viral Hepatitis, 1994, 1 , 1–13.

    Simmonds P. , 'Sequence variability of hepatitis C virus and its clinical relevance ' (1994 ) 1 J. Viral Hepatitis : 1 -13 .

    • Search Google Scholar

  • National University Hospital Singapore data: www.nuh.com.sg

  • Raghuraman, S., Abraham, P., Sridharan, G. et al.: Hepatitis C virus genotype 6 infection in India. Indian J. Gastroenterol., 2005, 24 , 72–3.

    Sridharan G. , 'Hepatitis C virus genotype 6 infection in India ' (2005 ) 24 Indian J. Gastroenterol. : 72 -3 .

    • Search Google Scholar

  • Mahtab, M. A., Rahman, S., Foster, G. et al.: Epidemiology of hepatitis C virus in Bangladeshi general population. Hepato Pancreato Bil. Dis. Int., 2008, 7 , 345–350.

    Foster G. , 'Epidemiology of hepatitis C virus in Bangladeshi general population ' (2008 ) 7 Hepato Pancreato Bil. Dis. Int. : 345 -350 .

    • Search Google Scholar

  • Davidson, F., Simmonds, P., Ferguson, J. C. et al.: Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5’ non-coding region. J. Gen. Virol., 1995, 76 , 1197–1204.

    Ferguson J. C. , 'Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5’ non-coding region ' (1995 ) 76 J. Gen. Virol. : 1197 -1204 .

    • Search Google Scholar

  • Viazov, S., Zibert, A., Ramakrishnan, K. et al.: Typing of hepatitis C virus isolates by DNA enzyme immunoassay. J. Virol. Methods, 1994, 48 , 81–91.

    Ramakrishnan K. , 'Typing of hepatitis C virus isolates by DNA enzyme immunoassay ' (1994 ) 48 J. Virol. Methods : 81 -91 .

    • Search Google Scholar

  • McOmish, F., Yap, P. L., Dow, B. C. et al.: Geographical distribution of hepatitis C virus genotypes in blood donors – an international collaborative survey. J. Clin. Microbiol., 1994, 32 , 884–892.

    Dow B. C. , 'Geographical distribution of hepatitis C virus genotypes in blood donors – an international collaborative survey ' (1994 ) 32 J. Clin. Microbiol. : 884 -892 .

    • Search Google Scholar

  • Andonov, A., Chaudhary, R. K.: Genotyping of Canadian hepatitis C virus isolates by PCR. J. Clin. Microbiol., 1994, 32 , 2031–2034.

    Chaudhary R. K. , 'Genotyping of Canadian hepatitis C virus isolates by PCR ' (1994 ) 32 J. Clin. Microbiol. : 2031 -2034 .

    • Search Google Scholar

  • Pozzato, G., Moretti, M., Franzin, F. et al.: Severity of liver disease with different hepatitis C viral clones. Lancet, 1991, 338 , 509–514.

    Franzin F. , 'Severity of liver disease with different hepatitis C viral clones ' (1991 ) 338 Lancet : 509 -514 .

    • Search Google Scholar

  • Pozzato, G., Kaneko, S., Moretti, U. et al.: Different genotypes of hepatitis C virus are associated with different severity of chronic liver disease. J. Med. Virol., 1994, 43 , 291–296.

    Moretti U. , 'Different genotypes of hepatitis C virus are associated with different severity of chronic liver disease ' (1994 ) 43 J. Med. Virol. : 291 -296 .

    • Search Google Scholar

  • Mori, S., Kato, N., Yagyu, A., Tanaka, T. et al.: A new type of hepatitis C virus in patients in Thailand. Biochem. Biophys. Res. Commun., 1992, 183 , 334–342.

    Tanaka T. , 'A new type of hepatitis C virus in patients in Thailand ' (1992 ) 183 Biochem. Biophys. Res. Commun. : 334 -342 .

    • Search Google Scholar

  • Tokita, H., Shrestha, S. M., Okamoto, H. et al.: Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group. J. Gen. Virol., 1994, 75 , 931–936.

    Okamoto H. , 'Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group ' (1994 ) 75 J. Gen. Virol. : 931 -936 .

    • Search Google Scholar

  • Murphy, D., Willems, B., Delage, G.: Use of the 5’ noncoding region for genotyping hepatitis C virus. J. Infect. Dis., 1994, 169 , 473–475.

    Delage G. , 'Use of the 5’ noncoding region for genotyping hepatitis C virus ' (1994 ) 169 J. Infect. Dis. : 473 -475 .

    • Search Google Scholar

  • Kleter, G. E. M., Van Doorn, L. J., Brolwer, J. T. et al.: Sequence analysis of the 5’ untranslated region in isolates of at least four genotypes of hepatitis C virus in the Netherlands. J. Clin. Microbiol., 1994, 33 , 306–310.

    Brolwer J. T. , 'Sequence analysis of the 5’ untranslated region in isolates of at least four genotypes of hepatitis C virus in the Netherlands ' (1994 ) 33 J. Clin. Microbiol. : 306 -310 .

    • Search Google Scholar

  • Bukh, J., Purcell, R. H., Miller, R. H.: At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. Proc. Nat. Acad. Sci. USA, 1993, 90 , 8234–8238.

    Miller R. H. , 'At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide ' (1993 ) 90 Proc. Nat. Acad. Sci. USA : 8234 -8238 .

    • Search Google Scholar

  • Stuyver, L., Trepo, C., Weiner, A. et al.: A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology, 1994, 19 , 1321–1324.

    Weiner A. , 'A proposed system for the nomenclature of hepatitis C viral genotypes ' (1994 ) 19 Hepatology : 1321 -1324 .

    • Search Google Scholar

  • Simmonds, P., Smith, D. B., McOmish, F. et al.: Identification of genotypes of hepatitis C virus by sequence comparisons in the core, El and NS- 5 regions. J. Gen. Virol., 1994, 75 , 1053–1061.

    McOmish F. , 'Identification of genotypes of hepatitis C virus by sequence comparisons in the core, El and NS- 5 regions ' (1994 ) 75 J. Gen. Virol. : 1053 -1061 .

    • Search Google Scholar
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Cover Hungarian Medical Journal
Hungarian Medical Journal
Print ISSN:
1788-6139
Online ISSN:
1789-0403

Hungarian Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
Volumes
per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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