Author: Xenia Gonda
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  • 1 Semmelweis University, Faculty of Medicine Department of Pharmacology and Pharmacotherapy Budapest Hungary
  • | 2 Semmelweis University, Faculty of Medicine Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center Kútvölgyi út 4 H-1125 Budapest Hungary
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The serotonin transporter gene plays a key role in the background of affective disorders and the neuroticism trait. Our aim was to investigate the association of the 5-HTTLPR polymorphism of the serotonin transporter gene and such components of neuroticism as depression, anxiety and affective lability in a psychiatrically healthy population. Participants completed the State-Trait Anxiety Inventory (STAI), the Zung Self-rating Depression Scale (ZSDS) and the TEMPS-A questionnaire. 5-HTTLPR genotype was established using PCR. Test scores were compared using ANOVA. Subjects carrying the s allele had a significantly higher score on the ZSDS, the state anxiety scale of the STAI and on those affective temperament scales which carry a depressive component. Our results indicate that components of neuroticism are independently associated with 5-HTTLPR suggesting that it is a unified and solid construct. Our results point to the importance of future research aimed at delineating the genetic background of personality traits observable in the healthy population, as these can serve as endophenotypes for neuropsychiatric disorders in future research.

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Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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