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Levél a szerkesztőhöz

Letter to the editor

Orvosi Hetilap
Author:
Zsófia Fekete
Restricted access

Abstract

The theoretical framework adopted in the analysis of Old English obstruents is laryngeal realism, a framework using privative features in modelling laryngeal oppositions. Equipollent oppositions, although real in the phonetic sense, must clearly be delineated from phonology. Old English obstruents are either unmarked (lenis/neutral) or marked: 〈b〉 /b/, 〈d〉 /d/, 〈cg〉 /dʒ/ or /ɟ/, 〈g〉 /ɡ/ are not marked for [voice] (although they are passively voiced between sonorants) and as such cannot regressively voice obstruents, singleton 〈p〉 /p/, 〈t〉 /t/, 〈ć〉 /tʃ/ or /c/, 〈c〉 /k/ are marked for [spread] (aspiration, or GW ‘glottal width’), singleton 〈f〉, 〈þ/ð〉, 〈s〉, 〈g〉, 〈h〉 are unmarked, but are passively voiced in the V ´ FricV/Son environment. Fricatives in unstressed syllables (even when couched between sonorants) are not voiced. If there is a sonorant separating the fricative from the stressed vowel there is no voicing ( V ´ SonFricV/Son). The only voiced fricatives after a stressed vowel+sonorant consonant are /f/ [v] and /x/ [ɣ] (but this is a historical coincidence). (Phonetically voiceless) Geminates, s+stop and f/h+stop clusters are special in that they constitute a sequence of a fortis followed by a lenis obstruent impervious to passive voicing.

Open access

Abstract

Chinese onion (Allium chinense G. Don) is an edible vegetable as well as a traditional Chinese medicine. It is rich in steroidal saponins and possesses broad health benefits. In this study, the optimal extraction protocol of the total saponins from Chinese onion (ACS) was explored, and the content of the total steroidal saponins in ACS reached 56.62%. Network pharmacology was applied to predict the related signalling pathways and targets between the main phytochemicals in ACS and hypercholesterolaemia. Enrichment analysis showed that ACS might intervene hypercholesterolaemia through the PI3K-Akt signalling pathway. Meanwhile, cholesterol-lowering effects were verified by ACS intervention in high-cholesterol diet-induced hypercholesterolaemia in Kunming mice. Compared with the model group, the TC and LDL-C levels of mice were decreased and the HDL-C level increased significantly after administration of ACS at a dose of 200 mg kg−1 day−1. The body weight gain, liver index, and atherosclerosis index all decreased dramatically. ACS could significantly reduce the fat content in the liver and reduce the number of fat droplets from the haematoxylin and eosin (H&E) staining of mouse liver. The immunohistochemical staining indicated that ACS could up-regulate the expression of PI3K protein in the liver, thus playing an anti-hypercholesterolaemic role. This study indicated that ACS exhibited significant therapeutic and preventive effects on hypercholesterolaemia, and exerted anti-hypercholesterolaemia through the PI3K-Akt signalling pathway.

Open access

Abstract

Nutritional problems can be seen in children living separated from their families. This cross-sectional pilot study aimed to evaluate intuitive eating, diet quality, and nutritional status of children living separated from their families. A total of 55 adolescent girls aged 12–18 years participated in the study. Anthropometric measurements, biochemical data, and 24-h dietary recall data were collected. The Intuitive Eating Scale-2 (IES-2) and the Turkish version of the Healthy Lifestyle-Diet (HLD-TR) index were used. Participants were divided into two groups according to their scores on the diet quality index using the 50th percentile. Group 1 consisted of participants with a score of 25 points or less, and Group 2 consisted of participants with a score above 25 points. Waist circumference (72.0 (66–83), 65.0 (60–77)) was significantly higher in Group 1 (P < 0.05). IES–2 score (3.05 (2.85–3.40), 3.30 (3.12–3.90)) and two sub–factors; reliance in hunger and satiety cues (2.80 (1.80–3.40), 4.00 (2.60–4.60)) and body–food choice congruence (2.50 (2.00–3.50), 3.50 (3.00–4.50)) were higher in Group 2 (P < 0.05). After adjustment for body mass index, age, and energy intake, there was a significant positive correlation between IES-2 and HLD-TR scores (P = 0.029). In conclusion, it may be advantageous to resort to strategies that promote intuitive eating to reduce obesity and associated problems in this vulnerable group.

Open access

Abstract

This intervention focuses on the close relationship that links Mithras to Hercules, witnessed by the presence of the image of Hercules in some mithraic caves, on ritual vessels and in other contexts related to Zoroastrian Mithraism, such as the funerary monument of Antiochus I of Commagene at Nemrut Dağı.

Likewise, even the veneration of the goddess Caelestis by some followers of Mithras is testified by the representation of the symbol pro itu et reditu in contexts referable to the cult of Mithras.

Restricted access
European Journal of Microbiology and Immunology
Authors:
Navid Dashti
,
Forough Golsaz-Shirazi
,
Haleh Soltanghoraee
,
Amir-Hassan Zarnani
,
Mehdi Mohammadi
,
Danyal Imani
,
Mahmood Jeddi-Tehrani
,
Mohammad Mehdi Amiri
, and
Fazel Shokri

Abstract

Background

Waning immunity and emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlight the need for further research in vaccine development.

Methods

A recombinant fusion protein containing the receptor-binding domain (RBD) fused to the human IgG1 Fc (RBD-Fc) was produced in CHO-K1 cells. RBD-Fc was emulsified with four adjuvants to evaluate its immunogenicity. The RBD-specific humoral and cellular immune responses were assessed by ELISA. The virus neutralizing potency of the vaccine was investigated using four neutralization methods. Safety was studied in mice and rabbits, and Antibody-Dependent Enhancement (ADE) effects were investigated by flow cytometry.

Results

RBD-Fc emulsified in Alum induced a high titer of anti-RBD antibodies with remarkable efficacy in neutralizing both pseudotyped and live SARS-CoV-2 Delta variant. The neutralization potency dropped significantly in response to the Omicron variant. RBD-Fc induced both TH2 and particularly TH1 immune responses. Histopathologic examinations demonstrated no substantial pathologic changes in different organs. No changes in serum biochemical and hematologic parameters were observed. ADE effect was not observed following immunization with RBD-Fc.

Conclusion

RBD-Fc elicits highly robust neutralizing antibodies and cellular immune responses, with no adverse effects. Therefore, it could be considered a promising and safe subunit vaccine against SARS-CoV-2.

Open access

Abstract

With the rise of the digital era, digital reading and learning have become widespread. University libraries, as core locations for study and communication, face challenges in fully meeting the demands of modern teaching and learning. This paper takes the library at the Changqing campus of Shandong University of Arts as a case study to explore the environmental space design of constructed libraries in the digital era. By reviewing relevant concepts and theoretical frameworks, analyzing the existing environment, and researching intervention design methods, the paper discusses the positive role of adapting to the digital future in renovating established library spaces.

Restricted access

Abstract

Streaming services spread rapidly. Among these services there are the linear TV, video library or program review system, while the online platform offering these contents is called mobile TV. A recommendation system may not only keep existing clients, but may also generate further turnover, should it introduce new content to the users. In this paper a recommendation system based on the Élő point calculation method is addressed. It is detailed how the programs should be grouped into different dimensions and what type of categories should be considered. Further, the idea of punch cards is introduced. Besides, the user profiles are set. The match system introduced by Élő is applied to the present situation. The system is introduced at a local mobile TV provider with 20,000 users.

Open access
Pollack Periodica
Authors:
Ali J. Mohammed
,
Hussein Hayder Mohammed Ali
,
Anwar S. Barrak
,
A. M. Hussein
, and
Murad Ramadan Mohammed

Abstract

A computational model is developed to investigate the convective heat transfer properties and the fluid flow characteristics of cupric oxide - water nano-fluid in a horizontal circular pipe aiming to provide insights into optimizing heat transfer in such systems. A twisted tape with varied twist ratios is inserted. This quantitative investigation used five Reynolds number from 4,000 to 12,000 under a uniform heat flux scenario of 25,000 W m−2. All experiments were performed as a single-phase fluid with cupric oxide values of 0, 0.4, 1, and 2% by volume. By reducing the twist ratio and increasing volume concentration, the average heat transfer coefficient of cupric oxide-water nano-fluid was improved. For a twist ratio of 4D, the maximum heat transfer improvement was 228% greater than the plain pipe. The presence of twisted tape with modest step ratios causes the friction factor to grow.

Restricted access

Abstract

This research aims to study the pullout resistance of a helical pile using three methods of machine learning techniques, which are: random forest regression, support vector regression, and adaptive neuro-fuzzy inference system, based on experimental results of a helical pile. The performance of these three techniques has been d compared and the results show that random forest algorithm has best performance than neuro-fuzzy inference system and support vector technique. The results show that machine learning considered a good tool in terms of estimating the pullout resistance of helical piles in the soil.

Open access