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Abstract
With a surge in critiques levelled against the evidence generated by randomised controlled trials in the study of psychedelic-assisted therapy (PAT), and the legalization of PAT in select jurisdictions such as Australia, and Oregon and Colorado in the United States, we consider what form the real-world evidence of its effects could take. Specifically, we propose to complement individual-level data-gathering (the usual remit of pharmacovigilance procedures) with evidence of PAT's collective effects. Taking our cue from long-standing claims that psychedelics are agents of social transformation, we draw upon the ‘transformative paradigm’ of evaluation, an approach that is itself oriented around social justice and change vis-à-vis marginalised expertise – or what we approach as ‘the grassroots’. To illustrate the potential of such grassroots evaluations, we offer eight examples of social issues that have been discussed in relation to PAT and psychedelics use and, for each, discuss the kinds of expertise that could be brought into the evaluation team and the kinds of questions that could be asked. We further describe our grassroots approach according to three values inspired by the qualities of grass roots themselves: rhizomatic accountability, dark reflexivity, and more-than-human hosting. We argue that these values align with the contemporary experience, practice, and context of PAT. We hope to generate discussion, innovation, and – ultimately – action toward specific study designs that are adequate to the task of documenting, and working with, the transformative potential of psychedelics in contemporary medicalized societies.
Abstract
Aims
Understanding how gambling harm is distributed is essential to inform effective harm reduction measures. This first national Australian study of gambling harm-to-self examined the extent, distribution, risk factors, and health related quality of life (HRQoL) impacts of this harm.
Methods
A Random Digit Dialling sample of 15,000 Australian adults was weighted to key population variables. Key measures included the Gambling Harms Scale-10 (GHS-10), PGSI, SF-6D, gambling behaviours, and demographics. Analyses included ordinal logistic regression.
Results
Amongst gamblers, 14.7% reported harm on the GHS-10, including 1.9% reporting high-level harm. While high-level harm occurred mainly in the problem gambling group (77.3%), other PGSI groups accounted for most of the more prevalent low (98.5%) and moderate (87.2%) harms reported. Proximal predictors of greater harm were use of online gambling and more frequent gambling on electronic gaming machines (EGMs), race betting sports betting, poker, skin gambling, scratchies, and loot box purchasing. Distal predictors were being younger, male, single, Aboriginal or Torres Strait Islander, and speaking a non-English language at home. At the population level, the greatest aggregate HRQoL impacts were amongst lower-risk gamblers, confirming the results of other studies regarding the ‘prevention paradox’.
Conclusions
The distribution of harm across gambler risk groups indicates the need for preventive measures, not just interventions for problem gambling. Reducing harm requires modifying product features that amplify their risk, especially for EGMs, race betting and sports betting that are both inherently risky and widely used. Gambling harm exacerbates health disparities for disadvantaged and vulnerable groups, requiring targeted resources and support.
Abstract
This commentary addresses the potential for a nocebo effect arising from the public discourse on psychedelics, especially considering the increasing interest and engagement with these substances. The resurgence of psychedelics in the public and scientific arenas has led to a proliferation of discussions, both positive and cautionary, about their use. However, an imbalance in this discourse, particularly a focus on potential harms without adequate contextualisation, might inadvertently create a nocebo effect. This effect could manifest in naturalistic settings, influencing individuals' experiences with psychedelics, possibly leading to adverse outcomes. The paper discusses the importance of a balanced narrative that equally acknowledges the benefits and risks associated with psychedelic use. It advocates for comprehensive and transparent information dissemination to enable informed decision-making by users.
Abstract
The Dark Triad is an important aspect of human personality, and there is evidence that it associated with infidelity. The current research aimed to examine the association between Narcissism, Psychopathy, and Machiavellianism traits and different aspects of infidelity in the Greek cultural context. In particular, using a sample of 509 Greek-speaking participants [57.5% women, mean age 36.5 (SD = 11.7), 42.5% men, mean age 40.1 (SD = 13.1)], we found that higher scores in Psychopathy were associated with higher incidence of infidelity and willingness to be unfaithful to one's partner. Moreover, men and women who scored higher in Psychopathy were more likely to be detected by their partners when unfaithful. Men who scored high in Psychopathy were also more suspicious of their partners for being unfaithful than men who scored low. However, the scores in the Dark Triad traits did not predict the probability to detect a partner's infidelity neither for men nor for women. Overall, in the Greek cultural context, the Dark Triad traits were associated with certain aspects of infidelity.
Abstract
Animal ethologists suggest that non-human primates console victims of aggression in a manner similar to humans. However, the empirical basis for this cross-species comparison is fragile, given that few studies have examined consolation behavior among humans. To address this gap, we revive and apply the underappreciated ethological branch of micro-sociology, which advocates the study of human interactions by applying ethological observation techniques. We thus systematically observed naturally occurring human consolation captured by video surveillance cameras in the aftermath of violent public assaults. Consistent with prior human and non-human primate research, social affiliation promoted consolatory helping. By contrast, we found no main effect of sex. A further exploratory analysis indicated an interaction effect between social affiliation and sex, with female affiliates having the largest probability of providing consolation. We discuss implications for the cross-species study of primate consolation and advocate that micro-sociology should reappraise ethological perspectives.
Abstract
Previous research has demonstrated that people remember negative reputational information particularly well. However, most of these experiments manipulated the type of information associated with each face, rather than manipulating the circumstances under which people learn this information. The present experiment examines the effect of the social situation on memory for social-exchange relevant information. Faces were paired with descriptions of cheating, trustworthy, or neutral behavior. In addition, the importance of the social situation was manipulated: Participants had either to decide if they would want to work with the described person on a student project (socially relevant scenario) or if they would want to ask this person what time it is while waiting at an airport (socially irrelevant scenario). A multinomial processing tree model was used to measure old–new item discrimination and source memory. Only in the socially relevant scenario a source memory advantage for cheaters was found.
Abstract
Background
This study contributes to the understanding of the efficacy, safety, and experience of ketamine-assisted therapy. The paper documents how individuals describe the effects of a protocolized and personalized use of ketamine (‘the relational dose’) in the context of group couples therapy based on Imago Relationship Therapy (IRT). Little is known about simultaneously administering ketamine to both members of a couple in this context, and no research to date has been published on whether ketamine facilitates couples to better engage in and benefit from the therapeutic process. The paper includes both qualitative and quantitative results.
Method
The study utilized a mixed methods approach. One approach was an inductive content analysis that produced overarching themes gleaned from participants' check-ins pre and post their weekly ketamine sessions. Transcripts were examined to better understand ketamine's effects on couples' ability to engage in therapeutic dialogue and resolve challenging relationship issues, as well as themes related to the non-ordinary-state-of-consciousness (NOSC) experience. The second approach involved the analysis of pre-test, post-test, and follow-up data from the Couples Satisfaction Index (CSI).
Results
The couples described a wide range of effects that ketamine produced in the context of their relational dialoguing including: empathogenic effects, mystical/spiritual/psychedelic experiences, anxiolytic and antidepressant effects. They also affirmed ketamine's ability to generate alternative perspectives, promote insight, heighten awareness, enhance vulnerability and communication, lower defenses, and produce novel somatic experiences. Participants' description of ketamine effects included its short duration, rapid onset, idiosyncratic sensitivity to dose, cumulative effects, as well as transient and mild side-effects. Several t-tests were statistically significant, and indicated improved relationship satisfaction following the treatment.
Conclusion
In the context of couples therapy, ketamine produced a wide range of therapeutic effects and possessed unique pharmacological properties as a rapid-acting novel psychoactive molecule. The drug may have profound therapeutic benefits when administered in the context of couples therapy, under clinical supervision, however more research should be carried out.
