Authors:H. Xie, L. Cao, L. Ye, G. Shan, and W. Song
In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3‐E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase signalling was performed in miR-1906 mimic-treated, receptor-activated nuclear factor kappa-B (NF-κB) ligand (RANKL)-induced osteoclasts. In-vivo, osteoporosis was induced by ovariectomy (OVX). Rats were treated with 500 nmol/kg of the miR-1906 mimic via intrathecal administration for 10 consecutive days following surgery. The effect of the miR-1906 mimic on bone mineral density (BMD) in OVX rats was observed in the whole body, lumbar vertebrae and femur. Levels of biochemical parameters and cytokines in the serum of miR-1906 mimic-treated OVX rats were analysed. The mRNA expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), p-38 and NF-κB in tibias of osteoporotic rats (induced by ovariectomy) was observed using quantitative reverse-transcription polymerase chain reaction. Treatment with the miR-1906 mimic reduced cellular toxicity and enhanced the cell viability of MC3T3‐E1 cells. Furthermore, osteoclastogenesis in miR-1906 mimic-treated, RANKL-induced osteoclast cells was reduced, whereas the BMD in the miR-1906 mimic-treated group was higher than in the OVX group of rats. Treatment with the miR-1906 mimic also increased levels of biochemical parameters and cytokines in the serum of ovariectomised rats. Finally, mRNA expression levels of TLR4, MyD88, p-38 and NF-κB were lower in the tibias of miR-1906 mimic-treated rats than in those of OVX rats. In conclusion, the miR-1906 mimic reduces bone loss in rats with ovariectomy-induced osteoporosis by regulating the TLR4/MyD88/NF‐κB pathway.
Authors:Donatella Fiorani, Marta Acierno, Silvia Cutarelli, and Adalgisa Donatelli
The use of digital technologies to study architecture and landscape has begun to represent an innovative aspect of the research when it started to allow the dynamic association (as input and output) of images and alphanumeric data: the different combination of this information through inferences and algorithms and the consequent generation of new data has freed digitisation from a strictly instrumental role making it a new methodological approach in itself.
As a matter of fact, recently architectural research has begun to take an interest in the problem ‘from within’, working not only on the application of computer tools but, more consciously, on their configuration. The work carried out by the Sapienza research group is aimed at developing ontologies and inferential models specifically dedicated to the representation of historical buildings and is devoted to the implementation of a national GIS platform for the historical centres, the Risk Map of the Italian Ministry of Cultural Heritage and Activities and Tourism.
This kind of work involves a series of methodological issues specially oriented to the definition of the role of the history of architecture in itself and its use for the conservation project. These arguments are developed within this essay, mainly focused on: type and quality of information deriving by the new procedures; interpretative components that fuel the new research methods; cost/benefit ratio in the use of ‘analogue’ and ‘digital’ approaches; future prospects of the two different (traditional and digital) investigative strategies. Moreover, both of the fields of digital research developed by the group (ontology and Risk Map) are here summarised.
A kutatásban azóta jelent meg innovatív szempontként a digitális technológiák használata az építészet és környezete tanulmányozásában, amióta a képek és alfanumerikus adatok dinamikus társítása (bemeneti és kimeneti formában) elkezdődött: az információk következtetések és algoritmusok révén létrejött különböző kombinációja, valamint az új adatok ezekből következő generálása megszabadította a digitalizálást szigorúan instrumentális szerepétől és önmagában új módszertani megközelítést hozott létre.
A közelmúltbeli építészeti kutatások tulajdonképpen „belülről” mutattak érdeklődést a probléma iránt, nemcsak a számítógépes eszközök alkalmazásával, hanem még tudatosabban a konfigurációval is foglalkoztak. A Sapienza egyetemi kutatócsoport munkájának célja kifejezetten történeti épületek bemutatására szolgáló ontológiák és következtetési modellek kifejlesztésére irányul azzal a szándékkal, hogy megvalósuljon a történeti központokra vonatkozó olasz nemzeti térinformatikai platform, az olasz Kulturális Örökség és Turizmus Minisztériuma kockázati térképe.
Ez a fajta kutatómunka módszertani problémák sorozatát foglalja magába, amelyek kifejezetten az építészettörténet szerepének meghatározására, valamint helyreállítási projektekben történő felhasználására irányulnak. Érveinket e tanulmányban fejtjük ki, elsősorban a következőkre összpontosítva: az új eljárásokból származó információ típusa és minősége; az új kutatási módszereket fellobbantó értelmező elemek; a költség-haszon arány az „analóg” és a „digitális” megközelítés alkalmazása esetén; a kétféle (hagyományos és digitális) vizsgálati stratégia jövőbeli kilátásai. Ezeken túlmenően összefoglalásra kerül a kutatócsoport által kifejlesztett digitális kutatás mindkét területe (ontológia és kockázati térkép) is.
The present report evaluates the protective effects of luteolin against diabetic retinopathy (DR).
Materials and methods
Diabetes was induced in rats by i.p. administration of 60 mg/kg of streptozotocin (STZ), followed by treatment with luteolin for 4 weeks. The effects of luteolin were determined based on the blood glucose and cytokine levels, and parameters of oxidative stress in retinal tissue of DR rats. The diameter of retinal vessels was estimated by fundus photography. A Western blot assay was used to determine the expression of apoptotic proteins and Nod-like receptor 3 (NLRP3) pathway proteins in the retina of DR rats. A molecular docking study was performed to evaluate the interaction between luteolin and NLRP3.
The level of blood glucose was reduced in the luteolin-treated group compared with the DR group. Reductions in cytokines and oxidative stress were observed in the retinal tissues of the luteolin-treated group relative to the DR group. Moreover, treatment with luteolin reduced the expression of NLRP1, NOX4, TXNIP, and NLRP3 proteins, and ameliorated the altered expression of apoptotic proteins in the retina of DR rats.
In conclusion, luteolin prevents retinal apoptosis in DR rats by regulating the NLRP/NOX4 signalling pathway.
This article addresses some shortcomings in the standard theory of the phonology-morphology interface within Government Phonology, which is built on the dichotomy of analytic/non-analytic morphology. I argue that many cases which had previously been thought to be analytic and therefore to require a cyclic application of phonology should be reinterpreted without: Many constructions that seemed to consist of domains inside domains are better understood without that internal structure. This alternative avoids some contradictory results of the standard model, which incorrectly precludes certain kinds of interactions between the nested domains. The reinterpretation also makes better sense of the phonological shape of (allegedly analytic) affixes by taking into account phonotactic possibilities of clusters with more than three consonants, which had so no far not received a satisfactory analysis in the Government Phonology literature.
Cake is a popular bakery product consumed by almost everyone due to its low economic cost and shelflife, however, it is recognised unhealthy because of high fat and sugar contents. The aim of this study was to evaluate physicochemical and sensory properties of muffins baked using 100% of sugar and fat replacement as stevia sweetener (rebaudioside A and erythritol) and chia seed mucilage, respectively. The combination of sweetener with chia gel (SCC) had the highest moisture content, while the replacement of fat in muffin (CC) revealed similarity to the control in lightness and redness values. There was also no significant difference in terms of firmness when only the sweetener was replaced (SC). While the control muffin obtained the highest overall acceptability score, the lowest score was observed in CC. Thus, muffins with reduced fat and sugar contents can benefit the consumer in terms of health, but further optimisation of formulations for both replacers is needed for better sensory acceptance.
Although the communist regime, in literature as well as in all areas of social life, aimed at uniformity and creating an “art” serving propaganda purposes in the entire Central and Eastern European region, the Romanian Stalinist “cultural project” differed in many respects from that of other countries, e.g. Hungary's. In this era, the discourse emphasizing revolutionary transformation and radical policy change decisively builds on the image of the enemy; and the fault-lines between past and present, old and new, and the idea of the need for continuous political struggle also prevail in both poetry and prose as eternal actualities.
For the Transylvanian Hungarian community, the 1989 Regime Change was supposed to mean the end of nationalist dictatorship, of the infinitely intensified ideological/political terror, of the deliberate policy of ethnic homogenization, and the solution of minority issues as well as of internal and external conflicts. Nevertheless, after a few months of cloudless enthusiasm, in 1990, Transylvanian Hungarians had to face the rearrangement of previous power structures; they confronted national and ethnic conflicts, disguised assimilation, and economic vulnerability. This paper aims to present the ideological/political characteristics which determined Transylvanian Hungarian poetry during the Communist Dictatorship and after the 1989 Regime Change.
Seventeen samples of Calabrian ewe’s milk, ewe’s cheese (Pecorino del Poro) made with raw milk, goat’s milk, and goat’s cheese (Caprino d’Aspromonte) made with raw milk were used to obtain 124 yeast isolates. The most abundant species was Debaryomyces hansenii (61.3%), followed by Candida zeylanoides (32.3%) and Kluyveromyces marxianus (3.2%). The enzymatic profile of 25 selected yeast strains was determined. Lastly, they were studied for their interaction with eight dairy lactic acid bacteria – four coccal-shaped and four rod-shaped. The best strains may be used as adjunct cultures for cheese making.
Authors:Ayad Q. Al-Dujaili, Amjad J. Humaidi, Daniel Augusto Pereira, and Ibraheem Kasim Ibraheem
Ball and Beam system is one of the most popular and important laboratory models for teaching control systems. This paper proposes a new control strategy to the position control for the ball and beam system. Firstly, a nonlinear controller is proposed based on the backstepping approach. Secondly, in order to adapt online the dynamic control law, adaptive laws are developed to estimate the uncertain parameters. The stability of the proposed adaptive backstepping controller is proved based on the Lyapunov theorem. Simulated results are presented to illustrate the performance of the proposed approach.
Authors:Borostyánkői Zsófia, Takács Szabolcs, and Szabó-Bartha Anett
Elméleti háttér: A Self-Criticizing/Attacking and Self-Reassuring Scale (Önkritikusság és Önmegerősítés Skála) magyar változatának köszönhetően az önkritikusság jelensége Magyarországon is mérhetővé vált. Cél: Jelen vizsgálat során bemutatásra kerül az Önkritikusság és Önmegerősítés Skála magyar mintán történő alkalmazhatósága, és az önegyüttérzéstől való félelem mellett a depresszióval, valamint az élettel való elégedettséggel vizsgált öszszefüggése. Módszerek: A kutatásban összesen 434 fő vett részt: 107 férfi és 327 nő, átlagéletkoruk 30,2 (SD = 12,15) év. Eredmények: A feltáró faktoranalízis az Önkritikusság és Önmegerősítés Skála (FSCRS-HU) esetén az eredetihez hasonló háromfaktoros struktúrát jelzett: a magyar mintán is megjelentek az alkalmatlan én (inadequate self), a megerősített én (reassured self) és a gyűlölt én (hated self) dimenziói. Ezt a struktúrát a konfirmatív faktoranalízis is megerősítette (RMSEA = 0,056; CFI = 0,945) és az alskálák belső megbízhatósága megfelelőnek bizonyult (Cronbach-α = 0,9; 0,87, 0,83, sorrendben). Az FSCRS-HU mind a depresszióval (r = 0,62 – 0,68; p < 0,01), mind az önegyüttérzéstől való félelemmel (r = 0,65 – 0,68; p = 0,01) és az élettel való elégedettséggel (r = [–0,51] – [–0,52]; p = 0,01) is szignifikáns, közepes erősségű együttjárást mutatott. Az életkor gyenge, az alkalmatlan én esetében pedig közepes mértékű szignifikáns hatása mindhárom alskálánál megjelent. A nemek közt azonban egyedül az alkalmatlan én esetén volt szignifikáns különbség (Z = –2,109; p = 0,040; rang Cohen-d = –0,229). Következtetések: Összességében az Önkritikusság és Önmegerősítés Skála megbízható és érvényes mérőeszköznek bizonyult hazai mintán is.
Background: Due to the Hungarian version of the Self-Criticizing/Attacking and Self-Reassuring Scale, the phenomenon of self-criticism has become measurable in Hungary as well. Aims: In the present study we present the applicability of the Self-Criticism and Self-Reassuring Scale on a Hungarian sample and its relationship to depression, life satisfaction, and fear of self-compassion. Methods: A total of 434 people participated in the research: 107 men and 327 women, with a mean age of 30.2 (SD = 12.15) years. Results: The exploratory factor analysis indicated a three-factor structure similar to the original version of the Self-Criticism and Self- Reassuring Scale, the Hungarian sample also showed the dimensions of the inadequate self, the reassured self and the hated self. This structure was also confirmed by confirmatory factor analysis (RMSEA = 0.056, CFI = 0.945) and the internal reliability of the subscales proved to be adequate (Cronbach's α = 0.9, 0.87, and 0.83, respectively). The FSCRS-HU showed a significant, moderate association with both depression (r = 0.62 – 0.68; p < 0.01) and fear of self-compassion (r = 0.65 – 0.68, p < 0.01) and life satisfaction (r = [–0.51] – [–0.52], p = 0.01). Age had a weak and, in the case of an inadequate self, a moderately significant effect on all three subscales. There was a significant difference between the sexes only in the case of the inadequate self (Z = –2.109, p = 0.040, rank Cohen’s d = –0.229). Conclusions: Overall, the Self-Criticism and Self- Reassuring Scale proved to be a reliable and valid measurement tool in the Hungarian sample as well.
During their university studies the Saxons of Brasov, who used to be one of the most influential urban communities of Transylvanian Saxons, had relationships with friends and colleagues. I want to particularly highlight the relationships documented by the occasional prints between 1650 and 1750. I want to find the answer to what social circles are mentioned in the occasional prints related to the Saxon students of Brasov during their peregrination. Therefore I will henceforth mostly make attempts to reconstruct their friendly and collegial relationships.
Occasional texts transition between correspondences and few-word memorial notes (especially regarding the number of writers and the length of writings). Thus a comprehensive storing and analysing of the occasional works restricted to a certain group can provide an opportunity to get informed about family, friendly and collegial relationships. Such writings may also contain valuable implications for the research of relation history. The relations that can be seen through these might add a lot in terms of success, especially if it is possible to continue the relation historical exploratory work connected to certain people. Furthermore, these data can be compared with their positions held during a later period of their lives, as well as with their family relations and high reputation within their community.