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Abstract

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3‐E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase signalling was performed in miR-1906 mimic-treated, receptor-activated nuclear factor kappa-B (NF-κB) ligand (RANKL)-induced osteoclasts. In-vivo, osteoporosis was induced by ovariectomy (OVX). Rats were treated with 500 nmol/kg of the miR-1906 mimic via intrathecal administration for 10 consecutive days following surgery. The effect of the miR-1906 mimic on bone mineral density (BMD) in OVX rats was observed in the whole body, lumbar vertebrae and femur. Levels of biochemical parameters and cytokines in the serum of miR-1906 mimic-treated OVX rats were analysed. The mRNA expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), p-38 and NF-κB in tibias of osteoporotic rats (induced by ovariectomy) was observed using quantitative reverse-transcription polymerase chain reaction. Treatment with the miR-1906 mimic reduced cellular toxicity and enhanced the cell viability of MC3T3‐E1 cells. Furthermore, osteoclastogenesis in miR-1906 mimic-treated, RANKL-induced osteoclast cells was reduced, whereas the BMD in the miR-1906 mimic-treated group was higher than in the OVX group of rats. Treatment with the miR-1906 mimic also increased levels of biochemical parameters and cytokines in the serum of ovariectomised rats. Finally, mRNA expression levels of TLR4, MyD88, p-38 and NF-κB were lower in the tibias of miR-1906 mimic-treated rats than in those of OVX rats. In conclusion, the miR-1906 mimic reduces bone loss in rats with ovariectomy-induced osteoporosis by regulating the TLR4/MyD88/NF‐κB pathway.

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Transformation of Tools and Conservation of Architecture •

Some Researches on the Use of Digital Systems for the Intervention on the Historical Buildings

Építés - Építészettudomány
Authors: Donatella Fiorani, Marta Acierno, Silvia Cutarelli, and Adalgisa Donatelli

The use of digital technologies to study architecture and landscape has begun to represent an innovative aspect of the research when it started to allow the dynamic association (as input and output) of images and alphanumeric data: the different combination of this information through inferences and algorithms and the consequent generation of new data has freed digitisation from a strictly instrumental role making it a new methodological approach in itself.

As a matter of fact, recently architectural research has begun to take an interest in the problem ‘from within’, working not only on the application of computer tools but, more consciously, on their configuration. The work carried out by the Sapienza research group is aimed at developing ontologies and inferential models specifically dedicated to the representation of historical buildings and is devoted to the implementation of a national GIS platform for the historical centres, the Risk Map of the Italian Ministry of Cultural Heritage and Activities and Tourism.

This kind of work involves a series of methodological issues specially oriented to the definition of the role of the history of architecture in itself and its use for the conservation project. These arguments are developed within this essay, mainly focused on: type and quality of information deriving by the new procedures; interpretative components that fuel the new research methods; cost/benefit ratio in the use of ‘analogue’ and ‘digital’ approaches; future prospects of the two different (traditional and digital) investigative strategies. Moreover, both of the fields of digital research developed by the group (ontology and Risk Map) are here summarised.

A kutatásban azóta jelent meg innovatív szempontként a digitális technológiák használata az építészet és környezete tanulmányozásában, amióta a képek és alfanumerikus adatok dinamikus társítása (bemeneti és kimeneti formában) elkezdődött: az információk következtetések és algoritmusok révén létrejött különböző kombinációja, valamint az új adatok ezekből következő generálása megszabadította a digitalizálást szigorúan instrumentális szerepétől és önmagában új módszertani megközelítést hozott létre.

A közelmúltbeli építészeti kutatások tulajdonképpen „belülről” mutattak érdeklődést a probléma iránt, nemcsak a számítógépes eszközök alkalmazásával, hanem még tudatosabban a konfigurációval is foglalkoztak. A Sapienza egyetemi kutatócsoport munkájának célja kifejezetten történeti épületek bemutatására szolgáló ontológiák és következtetési modellek kifejlesztésére irányul azzal a szándékkal, hogy megvalósuljon a történeti központokra vonatkozó olasz nemzeti térinformatikai platform, az olasz Kulturális Örökség és Turizmus Minisztériuma kockázati térképe.

Ez a fajta kutatómunka módszertani problémák sorozatát foglalja magába, amelyek kifejezetten az építészettörténet szerepének meghatározására, valamint helyreállítási projektekben történő felhasználására irányulnak. Érveinket e tanulmányban fejtjük ki, elsősorban a következőkre összpontosítva: az új eljárásokból származó információ típusa és minősége; az új kutatási módszereket fellobbantó értelmező elemek; a költség-haszon arány az „analóg” és a „digitális” megközelítés alkalmazása esetén; a kétféle (hagyományos és digitális) vizsgálati stratégia jövőbeli kilátásai. Ezeken túlmenően összefoglalásra kerül a kutatócsoport által kifejlesztett digitális kutatás mindkét területe (ontológia és kockázati térkép) is.

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Abstract

This article analyzes Ignác Goldziher’s portrayal of Ármin Vámbéry in his memorial lecture of 1915. Goldziher positioned Vámbéry, his teacher, as a Jewish Hungarian nationalist Orientalist and a foundational figure to Hungarology. Through this portrayal Goldziher opened the door to the notion that he, too, was like Vámbéry, a nationalist Hungarian Orientalist, despite the fact that his own work did not contribute to Hungarology, and did not display nationalist and patriotic tendencies as did Vámbéry’s. Goldziher’s portrayal of Vámbéry, thus, is a part of Jewish apologetics that emerged as a response to growing anti-Semitism during the early twentieth century.

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Abstract

The study demonstrated that cultivation of Pleurotus ostreatus var. florida, Pleurotus eryngii, Pleurotus cornucopiae and Pleurotus djamor on selenium enriched substrate did not significantly affect biological efficiency (%), but total soluble protein content, total phenolic content, flavonoid content and free radical scavenging activity (%) were found to be significantly improved in Se enriched fruit bodies as compared to the control. Elemental analysis of the Se biofortified Pleurotus mushrooms through SEM-EDS showed signals characteristic for selenium on surface of P. ostreatus. var. florida and P. djamor confirming that selenium was incorporated into the cell wall of these fruiting bodies. The Se content was found to be 22.34 μg g−1 dw in Se enriched wheat straw and 0.059 μg g−1 dw in respective non-enriched wheat straw. Se contents of Se-enriched fruit bodies were found to be higher compared to non-enriched Pleurotus spp. FT-IR spectra of proteins from Pleurotus spp. indicated an increase in the flexibility, unfolding, hydrophilicity of the proteins upon Se supplementation.

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Abstract

József Péczeli (1750–1792), a Calvinist minister educated at some of the outstanding German, Swiss and Dutch centres of knowledge, is mostly known for his editorial and publishing activities, including his translations of Voltaire’s dramas and epic works. However, this paper is meant to analyze the issues of calling and absolution as presented in “Moral Semons” edited and published by the “erudite minister of Révkomárom”. It argues that Péczeli’s sermons tend to show the influence of eighteenth century English theologians, thereby disseminating the ideas of modern practical theology, as well as interpreting and adapting them to the needs of young ministers serving in the communities of the various layers of contemporary Hungarian society.

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Résumé

L’ouvrage d’Anna TÜSKÉS s’appuie sur des recherches menées depuis déjà plus de dix ans (2008–2019) qui s’intéressent, de façon tout à fait originale, à certains aspects personnels, « privés », des relations littéraires entre la France et la Hongrie tout au long du siècle dernier. Ayant su mettre à profit des ressources non encore publiées du Musée littéraire Petőfi (Petőfi Irodalmi Múzeum), l’auteur réunit ici, en un dense ouvrage (383 pages), sept études distinctes au sujet d’écrivains ou traducteurs (ou encore spécialistes en arts plastiques) qui ont contribué à construire et renforcer les liens littéraires entre les deux pays, en dépit des vicissitudes historiques et politiques ayant, pendant presque un siècle, souvent menacé de les affaiblir. Les portraits individuels sont rassemblés autour d’une idée centrale, bien mise en valeur par l’auteur : le désir constant de dialogue éprouvé par des femmes et des hommes de Hongrie et de France, s’exprimant au travers d’écrits littéraires ou de correspondances, de poèmes lyriques ou cocasses, de photographies partagées… Ce livre à la très riche documentation donne à voir un tableau qui met en jeu non des « théories » littéraires, mais des sujets agissants et passionnés.

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Abstract

The paper presents a study of a Lower Carboniferous (Visean) clastic sequence commonly called Bobrikovsky Formation, deposited in the Volga-Ural Petroleum Province, Orenburg Region. Our investigation included sedimentological description of core samples from hydrocarbon wells and well log correlations. Facies were identified by well log patterns and calibrated by core sedimentology. The Bobrikovsky Formation is proposed to be interpreted as an overall transgressive-regressive succession in a nearshore-tidal environment. Transgressive lagoon-estuary and barrier island facies became regressional lagoon fill-type settings.

Open access
Journal of Behavioral Addictions
Authors: Elodie Hurel, Gaëlle Challet-Bouju, Marion Chirio-Espitalier, Malory Vincent, and Marie Grall-Bronnec

Abstract

Background

Social communication disorder (SCD) is a neurodevelopmental disorder that includes communication difficulties. Literature linking SCD and addictions is scarce, and there are only a few case reports regarding the co-occurrence of addiction and autism disorder spectrum, and only one of them addressed behavioural addictions.

Case presentation

We report MC’s case, who displayed an SCD and sexual addiction (SA). Clinical and neuropsychological evaluations suggested an alteration of social cognition, especially of affective theory of mind. This article also presents the adaptation made of the usual treatment.

Discussion

This case report illustrates the importance of social cognition abilities in the development and maintenance of behavioural addictions, and specifically SA. It also highlights the possible comorbidity of these two disorders and the possibility to work on social cognition as an alternate therapy in the treatment of behavioural addictions.

Conclusions

The co-occurrence of SCD and a behavioural addiction triggered clinical adaptations and implications that may affect a patient’s treatment presenting one of these disorders.

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Abstract

A product with increased quality and nutritional value can be developed by enriching noodles with shrimp meat (SM). The formulation of noodle dough was supplemented with SM (10, 20 and 30% w/w). The noodles were freeze-dried due to the susceptibility of added SM to spoilage. Water activity values of all samples were below 0.35. The highest protein (19.37 ± 1.04%), lipid (39.30 ± 1.69%), moisture (6.31 ± 0.42%) and energy (571.14 ± 10.16 kcal/100 g) contents were determined in noodles with 30% shrimp meat content (30S). Carbohydrate value of noodles decreased with the SM fortification level. Cooking quality characteristics of SM added noodles, especially 10S, were better in terms of weight gain, volume increase and cooking loss. The highest L* and b* values, which are expected to be high by the consumers, were reached with 10S and 30S, respectively. The value of a* increased with the addition of SM. Hardness, cohesiveness and chewiness values of the noodles increased with an increase in the level of shrimp content. Addition of SM improved the microstructure of noodles due to enriched protein matrix. Nutritious noodles with high cooking quality and a potential for long shelf life are intended for athletes and individuals with special nutritional needs.

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Imaging
Authors: Cesare Mantini, Francesco Corradi, Domenico Mastrodicasa, Luca Procaccini, Marzia Olivieri, Fabrizio Ricci, Filippo Cademartiri, Massimo Caulo, and Raffaele De Caterina

Abstract

The pericardial cavity, sinuses, and recesses are frequently depicted on Computed Tomography (CT) and Magnetic Resonance (MR).

We here review the normal human pericardial structures as provided by MR imaging of young, healthy subject and CT scans acquired after iatrogenic coronary dissection. We compared such radiological information with cadaveric axial and sagittal sections of the human body provided by the Visible Human Server (VHS), Ecole Polytechnique Federale de Lousanne (EPFL), Switzerland.

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