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Abstract

Based on the current literature, the link between Achilles tendon moment arm length and running economy is not well understood. Therefore, the aim of this study was to further investigate the connection between Achilles tendon moment arm and running economy and the influence of Achilles tendon moment arm on the function of the plantarflexor muscle-tendon unit during running.

Ten male competitive marathon runners volunteered for this study. The participants ran on a treadmill at two running speeds: 3 and 3.5 m s−1. During running the oxygen consumption, lower leg kinematics, electrical activity of plantar flexor muscles, and fascicle behavior of the lateral gastrocnemius were measured simultaneously. On the second occasion, an MRI scan of the right leg was taken and used to estimate the Achilles tendon moment arm length.

There was a negative correlation between running economy and the body height normalized moment arm length at both selected speeds (r = −0.68, P = 0.014 and r = −0.70, P = 0.01). In addition, Achilles tendon moment arm length correlated with the amplitude of the ankle flexion at both speeds (r = −0.59, P = 0.03 and r = −0.60, P = 0.03) and with the electrical activity of the medial gastrocnemius muscle at 3 m s−1 speed (r = −0.62, P = 0.02). Our finding supports the concept that a longer moment arm could be beneficial for distance runners.

Open access

Abstract

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3‐E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase signalling was performed in miR-1906 mimic-treated, receptor-activated nuclear factor kappa-B (NF-κB) ligand (RANKL)-induced osteoclasts. In-vivo, osteoporosis was induced by ovariectomy (OVX). Rats were treated with 500 nmol/kg of the miR-1906 mimic via intrathecal administration for 10 consecutive days following surgery. The effect of the miR-1906 mimic on bone mineral density (BMD) in OVX rats was observed in the whole body, lumbar vertebrae and femur. Levels of biochemical parameters and cytokines in the serum of miR-1906 mimic-treated OVX rats were analysed. The mRNA expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), p-38 and NF-κB in tibias of osteoporotic rats (induced by ovariectomy) was observed using quantitative reverse-transcription polymerase chain reaction. Treatment with the miR-1906 mimic reduced cellular toxicity and enhanced the cell viability of MC3T3‐E1 cells. Furthermore, osteoclastogenesis in miR-1906 mimic-treated, RANKL-induced osteoclast cells was reduced, whereas the BMD in the miR-1906 mimic-treated group was higher than in the OVX group of rats. Treatment with the miR-1906 mimic also increased levels of biochemical parameters and cytokines in the serum of ovariectomised rats. Finally, mRNA expression levels of TLR4, MyD88, p-38 and NF-κB were lower in the tibias of miR-1906 mimic-treated rats than in those of OVX rats. In conclusion, the miR-1906 mimic reduces bone loss in rats with ovariectomy-induced osteoporosis by regulating the TLR4/MyD88/NF‐κB pathway.

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Transformation of Tools and Conservation of Architecture •

Some Researches on the Use of Digital Systems for the Intervention on the Historical Buildings

Építés - Építészettudomány
Authors: Donatella Fiorani, Marta Acierno, Silvia Cutarelli, and Adalgisa Donatelli

The use of digital technologies to study architecture and landscape has begun to represent an innovative aspect of the research when it started to allow the dynamic association (as input and output) of images and alphanumeric data: the different combination of this information through inferences and algorithms and the consequent generation of new data has freed digitisation from a strictly instrumental role making it a new methodological approach in itself.

As a matter of fact, recently architectural research has begun to take an interest in the problem ‘from within’, working not only on the application of computer tools but, more consciously, on their configuration. The work carried out by the Sapienza research group is aimed at developing ontologies and inferential models specifically dedicated to the representation of historical buildings and is devoted to the implementation of a national GIS platform for the historical centres, the Risk Map of the Italian Ministry of Cultural Heritage and Activities and Tourism.

This kind of work involves a series of methodological issues specially oriented to the definition of the role of the history of architecture in itself and its use for the conservation project. These arguments are developed within this essay, mainly focused on: type and quality of information deriving by the new procedures; interpretative components that fuel the new research methods; cost/benefit ratio in the use of ‘analogue’ and ‘digital’ approaches; future prospects of the two different (traditional and digital) investigative strategies. Moreover, both of the fields of digital research developed by the group (ontology and Risk Map) are here summarised.

A kutatásban azóta jelent meg innovatív szempontként a digitális technológiák használata az építészet és környezete tanulmányozásában, amióta a képek és alfanumerikus adatok dinamikus társítása (bemeneti és kimeneti formában) elkezdődött: az információk következtetések és algoritmusok révén létrejött különböző kombinációja, valamint az új adatok ezekből következő generálása megszabadította a digitalizálást szigorúan instrumentális szerepétől és önmagában új módszertani megközelítést hozott létre.

A közelmúltbeli építészeti kutatások tulajdonképpen „belülről” mutattak érdeklődést a probléma iránt, nemcsak a számítógépes eszközök alkalmazásával, hanem még tudatosabban a konfigurációval is foglalkoztak. A Sapienza egyetemi kutatócsoport munkájának célja kifejezetten történeti épületek bemutatására szolgáló ontológiák és következtetési modellek kifejlesztésére irányul azzal a szándékkal, hogy megvalósuljon a történeti központokra vonatkozó olasz nemzeti térinformatikai platform, az olasz Kulturális Örökség és Turizmus Minisztériuma kockázati térképe.

Ez a fajta kutatómunka módszertani problémák sorozatát foglalja magába, amelyek kifejezetten az építészettörténet szerepének meghatározására, valamint helyreállítási projektekben történő felhasználására irányulnak. Érveinket e tanulmányban fejtjük ki, elsősorban a következőkre összpontosítva: az új eljárásokból származó információ típusa és minősége; az új kutatási módszereket fellobbantó értelmező elemek; a költség-haszon arány az „analóg” és a „digitális” megközelítés alkalmazása esetén; a kétféle (hagyományos és digitális) vizsgálati stratégia jövőbeli kilátásai. Ezeken túlmenően összefoglalásra kerül a kutatócsoport által kifejlesztett digitális kutatás mindkét területe (ontológia és kockázati térkép) is.

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Abstract

With the reform of China's childbirth policy in recent years, a unique baby boom phenomenon has emerged, and the new-born baby has increased rapidly in China. In the process of transformation and development of contemporary cities, a complex urban environment has a significant impact on psychology and physiology. The past kindergarten architectural aesthetic experience can no longer adapt to the social development needs. Thus, how to realize the sustainable development of kindergarten architecture has become a social problem that needs to be solved urgently. In the context of Environmental Psychology, this paper investigates the construction mode of experiential kindergarten architecture and tries to explore a new paradigm of educational architecture design in China for the future.

Open access

Abstract

The purpose of this paper is to investigate the pre-enrollment attributes of first-year students at Computer Science BSc programs of the University of Miskolc, Hungary in order to find those that mostly contribute to failure on the Programming Basics first-semester course and, consequently to dropout. Our aim is to detect at-risk students early, so that we can offer appropriate mentorship program to them. The study is based on secondary school performance and first-semester Programming Basics course results from the last decade of over 500 students. Secondary school performance is characterized by the rank of the school, admission point score, and foreign language knowledge. The correlation of these data with the Programming Basics course result is measured. We have tested three hypotheses, and found that admission point score and school rank together have significant impact on the first-semester Programming Basics course results. The findings also support our assumption that students having weaknesses in all examined pre-enrollment attributes are subject to dropout. This paper presents our analysis on students' data and the method we used to determine the attributes that mostly affect dropout.

Open access

Abstract

The laser tracker is a widely used instrument in many industrial and metrological applications with high demand measurement accuracy. Imperfections in construction and misalignment of individual parts deliver systematic errors in the measurement results. All error sources need to be identified and reduced to the minimum to achieve the best possible accuracy. The paper summarizes error sources of the laser tracker without beam steering mirror with emphasis on error modeling. Descriptions of error models are provided for the static and kinematic type of measurement.

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Abstract

The city of Prishtina has constantly been changing in urban, architectural, and technological terms. This has political, ecological, economic, and cultural consequences, especially in the downtown area, where higher-density, taller office buildings and commercial spaces and even more congested residential areas are planned. In this study, the Urban Gastro-Lounge is taken as an example of an adaptive reuse strategy for a whole building or its interior. This example of adaptive reuse aims to revive urban and architectural areas as a way of promoting the sustainable development of the city in terms of its general formal architectural morphology. The Urban Gastro-Lounge is an excellent example of this approach and is worthy of being considered a particularly useful intervention.

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Abstract

What happens, if a university moves to a town that never had a higher education institution previously? What is the impact of this development both on the community and the institution? The aim of this paper is to answer this question. The authors use the concept of ‘social innovation’ for understanding the developments. An institute may initiate, organise and coordinate all kinds of learning that takes place in a given community (Bradford, 2003). To do so, the institute may have to change its missions (not only its third, but also its first, second and third ones. These developments could be interpreted as a ‘social innovation’ during which the local economy and society was challenged and they looked for new responses. As suggested in the ‘social innovation’ literature the main research method was participatory research, combined with structured and semi-structured interviews, story-telling and narrative analyses. As a result, three interest groups could be described with various requirements different demands toward the university; while the university had to modify its structure, curriculum and communications. The main lesson to learn is that ’social innovation’ as a frame of interpretation can be used to understand the developmental processes that occurred between the locals and a new university.

Open access

Abstract

Most Education systems propose policies in pro of the benefit of society. However, successful application of these is unknown in consequence considering teachers voices is needed to understand the situations in the classroom. This study analyzes some English language teachers’ stories that served the purpose to construct themselves as professionals of language education facing the dichotomy of inclusion and exclusion placed by the mandates of the Colombian education system. The theme of Language Teacher Subjectivities, in this article, is conceptualized and discussed as the alternative s teachers have within their reach to use their own theories regarding language teaching and learning. Reflecting retrospectively and prospectively on meaningful school experiences related to the language teaching activity to tackle the dichotomy, the research question that guided this study was: What do language teachers’ narratives portray about their professional subjectivities in relation to inclusion? From a narrative perspective, narrative interviews and a professional life history timeline was analyzed using short story analysis focusing on when, when and who as meaningful in the data and finding that the participants comply with the multidimensional view of the subject. The narratives depicted that the corporal dimension, social-affective dimension, cognitive dimension, and ethic-moral dimension are part of the teachers’ professional subjectivities in the frame of Colombian inclusion policy.

Open access