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Abstract

Background and aims

Patients with schizophrenia are known to use potentially addictive psychoactive substances as self-medication and to ease psychological distress. Other potentially addictive behaviors such as online gaming are also used to self-medicate and ease psychological distress. However, the role of online gaming and problematic gaming (in the form of internet gaming disorder [IGD]) has not previously been investigated for patients with schizophrenia facing distress.

Methods

One hundred and four participants diagnosed with schizophrenia were recruited and completed a number of psychometric scales including the Personal and Social Performance Scale (PSPS), Internet Gaming Disorder Scale-Short Form (IGDS-SF9), Self-Stigma Scale-Short (SSS-S), and Depression, Anxiety, Stress Scale (DASS-21).

Results

The results showed significant negative associations between PSPS, IGDS-SF9, and DASS-21, and significant positive correlations between the IGDS-SF-9, SSS-S and DASS-21. Moreover, IGD did not mediate the association between self-stigma and depression. However, IGD significantly mediated the association between self-stigma and anxiety, and the association between self-stigma and stress. In addition, (i) age and self-stigma were significant predictors for IGD; (ii) social function and self-stigma were significant predictors for depression; (iii) social function, self-stigma, and IGD were significant predictors for anxiety; and (iv) self-stigma and IGD were significant predictors for stress.

Conclusion

The findings suggest that online gaming may be a coping strategy for individuals with schizophrenia with psychological stress and self-stigma and that for some of these individuals, their gaming may be problematic.

Open access

Abstract

The importance of preparation for citizenship has been recognized for millennia, while education for democracy has been central to pedagogical thinking in Europe and in Hungary for more than a quarter of a century (Crick Report, European Year of Citizenship through Education, EU key competences, modified version of the NCC). Educating a citizenry that is capable of thinking independently, is equipped with critical skills and can deliberate about matters appears in these documents as a definitive goal. The concept of civic competence or citizenship competence indicates a combination of such knowledge, skills, abilities and values that make the individual capable of effectively participating in an everyday life that is based on democratic values as well as in civic society (Hoskins and Crick, 2008, cited by Kinyó, Az állampolgári kompetencia egyes összetevőinek és a közösségi tevékenységformák jellemzőinek vizsgálata 7. és 11. évfolyamos tanulók körében[PhD dissertation: Individual Components of the Competence of Citizenship and an Examination of the Characteristics of Forms of Community Activities Among Students in the 7th to 11th Grades], 2012). The various models of preparation in schools assume that civic knowledge has identifiable elements that can be taught (e.g. texts of legal documents, constitutional principles, the structure of the state); at the same time, civic "knowledge" comprises rather the adoption of attitudes and the practice of certain skills. This study, supported by research data based on survey questions, seeks to discover the degree of prevalence of education for democracy and citizenship in everyday practice, as well as the kinds of problems those affected see in this area and what recommendations they have to address these difficulties.

Open access

Abstract

Our research team has developed a system and methodology for measuring psycho-physiological parameters, which can be used to determine the level of fatigue and fitness of the person being measured. This article describes the electroencephalography (EEG) part of this system. This article covers the technical and mathematical background of EEG measurement, the selection and implementation of the measurement tool in the development environment, and the development of the measurement and processing algorithm. The result is a system that can detect, digitize, and process the digitized signal from the brain, and save the processed signal in an XML database.

Open access

Abstract

Anticoagulant rodenticides (ARs) are widely used to control rodents. A method based on online turbulent flow chromatography (TFC) combined with LC-MS/MS has been established for rapid quantitative determination of eight ARs in human blood and urine. This method, which does not require time-consuming pre-processing steps, renders it especially suited for use in emergency poisoning cases. Sample preparation, including extraction, centrifugation, and filtration, was followed by online clean-up using TFC. The total run-time was within 13.5 min, including online purification, chromatographic separation, and re-equilibration of the TFC system. The parameters for sample extraction, purification, separation, and detection in this study were optimized separately. The linear regression coefficients of matrix-matched calibration standard curves established for quantification were greater than 0.9976. The limit of quantification (LOQ) for the method were found to be 0.3–3.0 ng/mL in human blood and 0.06–0.6 ng/mL in urine. The recoveries of spiked target compounds at different concentrations in human blood and urine were 91.8–111.9% and 86.9–105.3%, respectively. Inter- and intra-day precision values were both less than 12.5%, and the matrix effects of human blood and urine samples for ARs were 75.3–108.6% and 102.7–130.0%, respectively. This method had successfully applied to the emergency detection of ARs in biological samples of poisoned patients.

Open access

Abstract

This study describes the development of a method allowing the simultaneous separation and quantification of five statins by High performance liquid chromatography/Diode Array Detector (HPLC/DAD). Optimization was accomplished using chemometric tools such as the Design Space (DS) and Response Surface Methodology (RSM). Central Composite Design (CCD) and DS were applied for the optimization of the chromatographic procedure as well as the robustness of the chromatographic method by taking the ratio of the percentage of acetonitrile (%ACN) Buffer solution, the pH and the mobile phase flow rate as critical parameters. Satisfactory results were obtained after the optimization phase with a percentage of mobile phase equal to 46.19%, a pH of 4.16 and the flow rate is 1.4 mL min−1 by setting the resolution limits above 6, and the target retention time of 20 min. Using the DS and CCD approach, we have developed a robust and reliable procedure for the simultaneous and accurate separation and quantification of the five statins.

Open access

Abstract

The aim of the study is to give an insight into the evaluation of the program “Mentor Migration SALAM – Spielen Austauschen-Lernen-Achtsam-Miteinander” (Playing-Sharing-Learning-Attentively-Together). Students striving for a teaching degree or studying Social education at the University of Education Freiburg, mentor a child from a migrant or a refugee family for a period of 9 months. Some of the evaluation results are presented here. Based on different instruments like a questionnaire, open questions, interviews, reports, and minutes of the supervision meetings the mostly qualitative data are analysed and categorized. The article focuses on the impacts on the students: They gain a better awareness for intercultural encounters, and get insights into milieus they usually would not have. So especially the competences ‘Coping with Difference’ and ‘Professional pedagogical Skills’ will be investigated. The Intercultural Competence Model of Deardorff gives the theoretical background.

Open access

Abstract

Although glimepiride (GLM) is the first-line treatment of Type II diabetes, low extraction recovery is still a significant limitation in previous plasma analysis methods. An optimized solid-phase extraction method of GLM in human plasma with excellent extraction recovery, 100 ± 0.06%, was achieved using liquid chromatography-electrospray ionization tandem mass spectrometry and Gliclazide (GLZ) as an internal standard. GLM was extracted from 100 µL plasma sample using Sep-Pak® vac 1cc (100 mg) C18 column and methylene chloride: methanol (2: 1, v/v) as eluant. Both GLM and GLZ were monitored by a triple quad mass spectrometer applying positive multiple reaction monitoring mode (+MRM). The protonated precursor ions and product ions of GLM and GLZ were m/z 491(352), and m/z 324 (127), respectively. The detection and measurement of low levels of GLM in human plasma reached to picogram range (limit of detection (LOD) = 60 pg/mL, limit of quantification (LOQ) = 200 pg/mL). The method was validated in terms of selectivity, linearity, recovery, accuracy, and precision. The method was successfully applied to the pharmacokinetic study of GLM following oral administration of 1 mg GLM tablets to 12 healthy volunteers.

Open access

Abstract

In the experiments, the sound generated during the breaking of chocolate samples was examined. The fracture was performed by a precision penetrometer, the breaking sound was recorded. Texture index (TI) was calculated from the resulting signal. First the change of the resulting TI was monitored as a function of the samples' temperature. The sample groups of the same dark chocolate with different temperatures were completely separated from each other with statistical tool (LDA, linear discriminant analyses), but no trend was found to describe the change. Secondly, based on the TI, we could identify and classify the chocolate samples in the appropriate groups (based on cocoa content from 40 to 85%). According to linear discriminant analyses chocolates with different cocoa content were completely separated and showed a certain pattern. Based on the obtained results, it can be stated that the cocoa content of chocolate can be determined on the basis of TI obtained by acoustic method.

Open access

Absztrakt:

Bevezetés és célkitűzés: A nagy betegszám a sürgősségi osztályokon a dolgozók megterhelését növeli, a betegelégedettséget csökkenti. Ennek a tendenciának megállítására és javítására több módszert is bevezettünk 2019-ben. A COVID–19-járvány során a betegek a sürgősségi osztályt keresték fel azon panaszaikkal, amelyekkel amúgy a háziorvost vagy a szakambulanciákat keresték volna fel, továbbá a szakdolgozók több mint 15%-a a Koronavírus Ellátó Központban dolgozott 2020. áprilisban és májusban. Célunk volt felmérni a 2019-ben bevezetett intézkedéseknek, valamint a COVID–19-járvány okozta pluszmegterhelésnek a betegelégedettségre gyakorolt hatásait. Módszer: Longitudinális, kvantitatív, leíró jellegű, kérdőíves felmérést és dokumentumelemzést végeztünk a Pécsi Tudományegyetem Klinikai Központ (PTE KK) Sürgősségi Orvostani Tanszékének Sürgősségi Betegellátó Osztályán 2019. április 1. és 2020. május 31. között (n = 999). A felmérés első részében 354, a második részében 645 kérdőívet elemeztünk, valamint a dokumentumelemzés során a betegszámokat használtuk fel. Az adatelemzéshez leíró statisztikát, kétmintás t-próbát és Mann–Whitney-tesztet végeztünk (p<0,05). Eredmények: A felmérés első hónapjában a páciensek és hozzátartozók 51%-a értékelte pozitívan a PTE KK Sürgősségi Orvostani Tanszékének Sürgősségi Betegellátó Osztályát, míg novemberre ez az arány 99%-ra emelkedett. A kommunikációs tréninget és egyéb intézkedéseket követően pozitív irányba változott az ápolókról (Z = –2,25, p = 0,024), az orvosokról (Z = –2,25, p = 0,024) és az osztályról (Z = –2,24, p = 0,025) alkotott vélemény. A COVID–19-járvány alatt csökkent a betegelégedettség: a dolgozók viselkedését (Z = –4,16, p<0,001) és a szolgáltatások minőségét (Z = –3,88, p<0,001) is rosszabbnak ítélték. Következtetés: A bevezetésre került intézkedéseink pozitív hatásait mérhetjük a betegelégedettség növekedésén keresztül. Eredményeink rámutatnak arra, hogy a COVID–19-járvány miatti dolgozói megterhelés negatívan befolyásolta a betegelégedettséget. Orv Hetil. 2020; 161(43): 1819–1823.

Open access