Abstract
The use of antibiotics in agriculture and subsequent environmental pollution are associated with the emergence and spread of multidrug-resistant (MDR) bacteria including Escherichia coli. The aim of this study was to detect antimicrobial resistance, resistance genes and mobile genetic elements of 72 E. coli strains isolated from faeces of healthy farm animals. Disk diffusion test showed resistance to ampicillin (59.7%), tetracycline (48.6%), chloramphenicol (16.7%), cefoperazone and ceftriaxone (13.9%), cefepime and aztreonam (12.5%), norfloxacin and ciprofloxacin (8.3%), levofloxacin (6.9%), gentamicin and amikacin (2.8%) among the studied strains. Antibiotic resistance genes (ARGs) were detected by polymerase chain reaction: the prevalence of bla TEM was the highest (59.7% of all strains), followed by tetA (30.6%), bla CTX-M (11.1%), catA1 (9.7%), less than 5% strains contained bla SHV, cmlA, floR, qnrB, qnrS, tetM. 26.4% of E. coli strains had a MDR phenotype. MDR E. coli more often contained class 1 integrons, bacteriophages, conjugative F-like plasmids, than non-MDR strains. ARGs were successfully transferred from faecal E. coli strains into the E. coli Nissle 1917 N4i strain by conjugation. Conjugation frequencies varied from (1.0 ± 0.1) * 10−5 to (7.9 ± 2.6) * 10−4 per recipient. Monitoring mobile genetic elements of E. coli for antibiotic resistance is important for farm animal health, as well as for public health and food safety.
Néhány gondolat az avar kori fülkesírok értelmezéséhez
Some thoughts on the interpretation of the graves with an end-wall shaft
A fülkesírok eredete már régóta megoldatlan kérdése az avar kor kutatásának. Jelen tanulmányban új szempontokat kívánunk nyújtani a sírforma értelmezéséhez. Ehhez belső- és közép-ázsiai, valamint kelet-európai analógiákat mutatunk be. Ezek a kora avar kori sírokhoz képest jóval korábbiak, néhány esetben egykorúak. A padmalyos sírokkal való együttes előfordulásuk alapján a két típus valószínűleg egymás formai variánsaként értelmezhetők.
This paper addresses several important aspects of the historical spread of the Huayan and Chan Buddhist teachings in the Tangut state, and traces local developments of Chan and Huayan thought among the Tang-uts. These developments, as they emerge from the received texts, indicate not only local developments in Xixia, but also provide broader implications for the study of Sinitic Buddhism in Northern China and Central Asia during 11th–13th centuries. The core of the paper concerns Tangut Huayan commentaries, the Huayan lineage composed by Yixing Huijue, Tangut recensions of texts authored by Guifeng Zongmi and the Tangut texts of Hongzhou Chan Buddhism.
The word T1G2 occurs three times in the Ongi Inscription. The sentences containing T1G2 have been interpreted in a variety of ways, with no single reading thus far being deemed satisfactory. A notable aspect of the Old Turkic script is the presence of two distinct characters for the majority of consonant sounds, one representing a back-vocalic and the other a front-vocalic sign. Given that T1G2 occurs on three occasions, it is plausible that the individual(s) responsible for inscribing the text may have deliberately employed this format. The author hypothesizes that T1G2 in question represents the Turkic rendering of the Chinese character dí 敵, which translates to “enemy; hostile.”
This study examines the influence of Mongolian language on spoken Chinese, with a focus on the Sino-Mongolian, or Chinese language translated using the literal translation style (zhiyi-ti 直譯體) from Mongolian. Sino-Mongolian was a type of contact language, based on the Chinese vocabulary and Mongolian syntactic structure. Common linguistic elements are observed between Sino-Mongolian and the Chinese textbook No Gŏltae edited in the Koryŏ Kingdom under Mongol rule. The analysis confirms that No Gŏltae was not translated from Mongolian language but a type of spoken Chinese that was influenced and shaped by Sino-Mongolian through oral dissemination. Although Sino-Mongolian was an artificially translated language, the literal translation style may have been based on Altaic Pidgin Chinese. Hence, it was readily accepted in Northern China and naturally influenced and shaped the spoken Chinese there. It is concluded that the colloquial Chinese influenced by Sino-Mongolian, as observed in No Gŏltae, would be defined as Mongolo-Chinese, a type of Creole language.
Abstract
Background
Research on individual differences in brain structural features of internet gaming disorder (IGD) and established addictions such as tobacco use disorder (TUD) is currently limited. This study utilized normative modeling to analyze the cortical thickness (CT) development patterns of male patients with IGD and TUD, aiming to provide further insights into whether IGD qualifies as an addiction.
Methods
Surface-based brain morphometry (SBM) was used to calculate CT from T1-weighted magnetic resonance imaging data of 804 male participants (665 healthy individuals, 68 IGD and 71 TUD). Gaussian process regression was employed to generate normative models of CT development. Deviation maps were produced to depict deviations of IGD and TUD participants from the typical developmental patterns.
Results
Both addiction groups exhibited widespread cortical thinning, particularly in regions such as the bilateral temporal pole and medial orbitofrontal cortex. The TUD group demonstrated a higher degree of individualization and limited spatial overlap compared to the IGD group. Opposite trends in CT changes were observed between the two groups in the bilateral pericalcarine cortex and pars triangularis.
Conclusions
These findings regarding the similarities and differences between IGD and TUD provide support for the idea that IGD shares common features with substance-related addictions and contribute to a deeper understanding of the neural mechanisms underlying IGD.
Abstract
Formaldehyde plays a significant role in the global economy due to its unique chemical properties and widespread use in both the medical field and various industrial sectors. However, formaldehyde (HCHO) is classified as a persistent organic pollutant and is known to be harmful. Exposure to formaldehyde, both direct and prolonged, can cause severe health issues and potentially lead to death. It is recognized as a human carcinogen by numerous organizations and can negatively impact the endocrine system, as well as having mutagenic or teratogenic effects. Formaldehyde has been detected in various matrices at levels exceeding those permitted by international health regulatory bodies. Chromatography, particularly high-performance liquid chromatography (HPLC) coupled with detection methods, is an analytical technique frequently used to determine volatile organic molecules, including formaldehyde. This investigation aimed to develop and validate an assay method to identify and quantify formaldehyde in cosmetic products using HPLC-PDA. The chosen isocratic system consisted of a ZORBAX RX-C8 column (250 mm × 4.6 mm; 5 μm) and a mobile phase mixture of acetonitrile and water in a 55:45 (v/v) ratio, with a flow rate of 1.5 mL min−1. Formaldehyde was detected at 353 nm after derivatization with a 0.1N 2,4-dinitrophenylhydrazine solution, with a retention time of approximately 5.0 min and a total run time of 7.0 min for formaldehyde. The method was validated according to ICH Q2 (R1) guidelines. The validation parameters demonstrated high selectivity, precision (RSD <2%), accuracy (mean recovery of 101.3%), linearity (r > 0.995 in the 1,000–2,400 ppm range), and a limit of quantification (LOQ) of 0.1 ppm. The validated analytical method was applied to 35 cosmetic products. None of these products were labeled as containing formaldehyde, although 6 imported products were labeled as containing formaldehyde-releasing preservatives. The results indicated that 88.6% of the samples tested positive for formaldehyde, with free formaldehyde levels ranging from 20 to 981 ppm. All samples contained formaldehyde levels below the 2000 ppm threshold.
Mikolás Tibor és a kelet-magyarországi modernizmus
Tibor Mikolás and Modernism in Eastern Hungary
Mikolás Tibor (1924–2024) Debrecen és Kelet-Magyarország egyik meghatározó építésze volt. 2024-ben a kétszeres Ybl-díjas és Széchenyi-díjas alkotóművész születésének 100 éves évfordulóját ünnepeljük. A Debreceni Egyetem Műszaki Kar Építészmérnöki Tanszékén célul tűztük ki az igen gazdag életmű feldolgozását. A mesterszakos hallgatókkal együtt sorra vettük szakmai fejlődésének stációit, a háború utáni klasszikus modern építészetet oktató iskola és mesteriskola, a szocialista realizmus, az 1960-as évek szabadabb építészeti gondolkodása és az 1970-es évektől előretörő előregyártási kényszer keretei között született jellemző épületek, tervpályázatok és koncepciótervek bemutatásával. Az építészeti projektek feldolgozásánál azt a hallgatók által szerethetőbb módszert választottuk, mely szerint az épületeket mai vizualizációs programokkal reprodukáltuk, ezáltal azok érthetősége is változott. Párhuzamot vonva a tervek születésének dátumával tisztázódtak azok az építészetét meghatározó alapgondolatok, amelyek mentén az épületek születtek. 1963-ig például létezett egy rá jellemző színvilággal kevert homlokzati rajzosság, utána inkább a funkcióból eredő letisztultsággal találkoztunk. A tanulmány célja bemutatni az életutat, a terveken keresztül bizonyítani, hogy bár voltak a közel 50 éves tervezői pályafutásnak evolúciós lépései, de összességében ars poeticáját a klasszikus modernizmus és a funkcionalizmus határozta meg.
Abstract
The paper provides a close reading of Plotinus' obscure chapter Ennead IV.6.2. I try to make clear, beyond the central thesis that sense-perception is an active power, how it contributes to the argument of the whole treatise, how its seemingly disconnected comments make up a coherent line of thought, and how it remains consistent with Plotinus' positions expressed elsewhere.
Abstract
The article covers the issue of ecological security in Poland with a view to international regulation, the objectives of which are pursued at the municipality level, i.e., the basic unit of local government. It is in local areas and at the source of any threat that a rapid response is often needed to eliminate environmental pollution and its effects. Accordingly, the municipal authorities have been equipped with a number of powers enabling them to take action for environmental safety. It should be assumed as a research hypothesis that, in terms of activities in the sphere of ecological security, a municipal authority is a body that complements the activities of the state resulting from EU obligations and other higher-level local government units and that these activities are aimed at issues closest to individuals. The study is characterised by a legal theory-based approach. The main research method used in the study is the doctrinal method, as well as the method of legal text analysis. It mainly draws on theoretical views presented in legal studies and those offered in case law practice.
