Abstract
Background and aims
Negative/positive urgency (NU/PU) refers to the proneness to act rashly under negative/positive emotions. These traits are proxies to generalized emotion dysregulation, and are well-established predictors of gambling-related problems. We aimed to replicate a previous work (Quintero et al., 2020) showing NU to be related to faulty extinction of conditioned stimuli in an emotional conditioning task, to extend these findings to PU, and to clarify the role of urgency in the development of gambling-related craving and problems.
Methods
81 gamblers performed an acquisition-extinction task in which neutral, disgusting, erotic and gambling-related images were used as unconditioned stimuli (US), and color patches as conditioned stimuli (CS). Trial-by-trial predictive responses were analyzed using generalized linear mixed-effects models (GLME).
Results
PU was more strongly related than NU to craving and severity of gambling problems. PU did not influence acquisition in the associative task, whereas NU slightly slowed it. Extinction was hampered in individuals with high PU, and a follow-up analysis showed this effect to depend on relative preference for skill-based and casino games.
Discussion and conclusions
Results suggest that resistance to extinction of emotionally conditioned cues is a sign of malfunctioning emotion regulation in problematic gambling. In our work, the key effect was driven by PU (instead of NU), and gambling craving and symptoms were also more closely predicted by it. Future research should compare the involvement of PU and NU in emotion regulation and gambling problems, for gamblers with preference for different gambling modalities (e.g., pure chance vs skill games).
Abstract
In this study, a UPLC-MS/MS method was developed for determination of pancratistatin in the mouse blood, and the pharmacokinetics of pancratistatin in mice after intravenous (5 mg kg−1) and intragastric (15 mg kg−1) administration was studied. HSS T3 column was used for separation with mobile phases of acetonitrile and 0.1% formic acid using gradient elution procedure. The blood sample was treated by protein precipitant with acetonitrile, midazolam was used as internal standard (IS). Multiple reaction monitoring mode (MRM) was used for quantitative analysis, m/z 326.2→83.8 for pancratistatin and m/z 326.2→291.4 for IS in electrospray (ESI) positive interface. It showed a good linear in the range of 10–4,000 ng mL−1 (r > 0.998); the intra-day and inter-day precision was <15%, and the accuracy was 93%–105%. The recovery was better than 82%, and the matrix effect was 94%–105%. The developed UPLC-MS/MS method was fast, selective, and suitable for the pharmacokinetics of pancratistatin in mice.
Abstract
The literature on fusidic acid resistant Staphylococcus aureus strains is scarce in Iran, although the emergence of these strains in health care settings is increasing. This descriptive cross-sectional study was conducted on 68 fusidic acid resistant S. aureus strains to learn about the molecular characteristics and antimicrobial resistance of strains isolated from hospitalized patients. In the present study, the prevalence of resistance to fusidic acid in S. aureus isolates was 15.1%. Fusidic acid resistance determinative factors (fusB, fusC and fusD) were identified by multiplex PCR assay. To detect the existence of fusA and fusE determinants and their mutation status, amplifications and sequencing were performed. Molecular characterization of fusidic acid resistant isolates was investigated by SCCmec and spa typing methods. All strains were MRSA and multi drug resistant. Two (2.9%) and 31 (45.6%) isolates were resistant to vancomycin and mupirocin respectively. The SCCmec type IV was highly prevalent representing 50% followed by types III (51.5%), and SCCmec types II (13.2%). fusB, was the most predominant acquired gene (66.2%) followed by fusC (19.1%), and fusA (14.7%). The mutations in fusA were present in 10 isolates with 5 (50%) having L461K mutation showing fusidic acid MIC values of ≥256 μg ml−1 followed by H457Y (40%), and H457Q (10%) showing fusidic acid MIC values of 128 and 64 μg ml−1 respectively. Isolates were allocated to ten particular t030 (22.1%), t037 (14.6%), t408 (11.8%), t064 (11.8%), t008 (10.3%), t002 (8.8%), t005 (5.9%), t790 (5.9%), t318 (4.4%), and t018 (4.4%) spa types. fusA positive isolates were assigned to particular spa types t002 (60%), and t005 (40%). There may be be a spreading of fusidic acid resistance among MRSA, creating worrying public concern. This research notes the importance of adequate data of local prevalence of FA-resistant MRSA in Iran for taking appropriate measures to treat, control and reduce the incidence of these isolates.
A zsámbéki Öregtemplom építőanyagának vizsgálata: esettanulmány
Experimental Test on the Building Material of the Old Church in Zsámbék: A Case Study
A zsámbéki romtemplom az ország egyik legismertebb műemléke. Története során számos alkalommal átépítették, felújították már mielőtt lepusztult volna. Azóta már több terv is született, hogy milyen irányba kellene a rom hasznosítását terelni. Ezek széles variációkkal rendelkeztek, attól kezdve, hogy legfeljebb csak állagmegóvás legyen egészen odáig, hogy teljesen visszaépítsék. Időről időre előkerül mindig ez a kérdés. Ez az esettanulmány is egy tervezés előtti felmérés keretén belül született. A tanulmány a rom építőanyagainak, főleg az eredeti kőanyag és habarcs vizsgálataival, azok mostani állapotával foglalkozik. Egy átfogó felmérés is készült a templomról, amely feltérképezi, hogy hol, milyen anyagból áll a szerkezet.
Abstract
The manufacturing of cement liberates the green-house gasses into atmosphere. To overcome this problem so many alternative materials has been invented by researchers to minimize addition of cement. The incorporation of these alternative materials as cementitious material in concrete enhances the attributes of concrete. In this scenario metakaolin gained momentum as a substitution to cement in concrete. Most of the researchers studied the performance of concrete incorporating metakaolin as cementitious material in normal curing conditions. There is a need for analysing the impact of accelerated curing on properties of concrete by incorporating metakaolin as cementitious material. The current construction industry needs high early strength for removal of form work in early ages. The accelerated curing is a method which provides high early strength. In this study, different proportions of metakaolin are added as partial alternative to cement and cured in accelerated curing tank for 3.5 h. The strength parameters test, durability test, and micro-structural parameter tests are performed on these samples. Further, micro-structural analysis has been carried out using SEM, and EDX tests. Results depicted the incorporation of 15% of metakaolin as substitute to cement amplifies the overall performance of concrete in accelerated curing regime.
Abstract
A computational fluid dynamics numerical model addressed the problem of local scouring and deposition calculation for non-cohesive sediment and clear water conditions near single and double cylindrical piers. The numerical results of single cylindrical piers correlate very well with the physical model's results while are higher than the case of the double pier, especially when the large-eddy turbulence model, the van Rijn bed-load transport equation, and fine mesh size are considered. Additionally, the final numerical predictions are compared to experimental data after parameters effectiveness explores the range of results based on projected user inputs like the bed-load equation, mesh cell size, and turbulence model.
Abstract
The rapid technological development that is still taking place today, with increasingly interconnected IT tools, is introducing dramatic changes. The development of computer programs is rapidly transforming traditional processes and the systems that support them. It is therefore natural that the fourth industrial revolution (Industry 4.0) and its impact on Hungarian companies is one of the key topics of our time. We conducted an exploratory quantitative survey, asking 140 managers of Hungarian small, medium and large enterprises about their current situation in the context of Industry 4.0. We sought to find out to what extent the specific R&D and innovation potential of Industry 4.0 is accepted, and whether it has already been introduced in the companies. On a qualitative side, 2 case studies and 3 interviews were conducted, in which structured interviews were used to further explore the issue. We aimed to find out where SMEs stood in terms of digital preparedness and what advantages, possible disadvantages, and goals they managed to identify. Our research showed that an increasing number of companies have already decided to take the first steps towards industrial digitalisation, which will completely transform their internal processes.
Abstract
The gear is the most efficient and reliable portion of the transmission system. In machine tools, gears are utilized to handle heavy loads. These gears are used indefinitely if the prerequisites are met. Gear tooth bending stress for numerous spur gears has been examined in this research. The influence of changing the pressure angles on the spur gear tooth root stress has been investigated. The purpose of this study is to look for a new way of finding the stresses generated in the roots of the gear teeth as well as the effect of changing pressure angles on these stresses. Solidworks 2021 uses parametric formulation to model gears, analyzed for deformation and maximum bending stress in ANSYS. The airy stress function is used to conduct the nominal root tooth stress. The enhancement percentages of modified cases are 5.92%, 1.70%, 10.70%, 17.22%, 10.86%, 24.32%, 20.91%, and 26.15% for the cases 2, 3, 4, 5, 6, 7, 8, and 9, respectively according to the stress function findings.
Abstract
Background and aims
It has been argued that it is important to consider underlying mechanisms of mental health problems. Previous studies have shown that executive deficits, delay aversion, and emotion dysregulation are related to Internet Gaming Disorder (IGD) and Social Media Disorder (SMD). However, the present study is the first to investigate whether these neuropsychological deficits show additive effects or if they interact. The present study also investigated whether these deficits mediate the association between IGD/SMD and psychosocial outcomes.
Methods
The study involved 995 university students who completed a survey measuring IGD/SMD symptom severity, neuropsychological functions, and psychosocial outcomes. Both dimensional and categorical analyses were used to assess the associations between neuropsychological functions and IGD/SMD. Simple and multiple mediation analyses were conducted to examine if neuropsychological functioning mediates the association between IGD/SMD and psychosocial outcomes.
Results
All neuropsychological functions were significantly associated with both IGD and SMD symptom severity. However, only inhibition and emotion regulation, as well as delay aversion for SMD, remained significant when controlling for the overlap between different functions. Associations were significantly stronger for men compared to women for IGD. In the categorical analyses, individuals with IGD/SMD were more likely to have neuropsychological deficits (odds ratios between 3.33 and 8.81). Finally, all neuropsychological functions, except inhibition, were significant mediators in the link between IGD/SMD and psychosocial outcomes.
Discussion and conclusions
These results shed light on the neuropsychological underpinnings of IGD/SMD, which can be used to identify more homogenous subgroups and provide more individualized treatment options.
Abstract
The thermo convective instability of the Darcy-Benard problem (DB) using Robin (third-kind) thermal conditions is investigated here. We consider a viscous Newtonian fluid saturating a porous layer in which the layer is sandwiched between two impermeable boundaries. The upper and the lower walls are modelled in the form of the Neumann (second-kind) and the Robin (third-kind) thermal conditions, respectively. The difference in the temperature distribution between both phases allows the lack of a local thermal equilibrium model to be present. As a consequence, the third kind of thermal condition brings about one extra dimensionless parameter of the Biot number to the usual one of the inter-heat transfer coefficient and the thermal conductivity ratio. The normal modes method adopted in a linear stability analysis gives rise to perturbed governing equations. The eigenvalue problem is handled numerically as a result of the perturbed governing equations leading to the marginal stability condition.
