Among all scientific traditions alive, medical publishing has a good chance to be the oldest. The first fully peer reviewed academic journal, “Medical Essays and Observations” was launched in 1731 by the Royal Society in Edinburgh. Since then, hundreds of medical journals have been published worldwide. Medical publication in Hungary started in 1857 when the famous physician, Markusovszky founded “Orvosi Hetilap”, which has been published since then every week (with short breaks during the world wars). It is now a most prestigious piece in AKJournals’ portfolio, listed in Journal Citation Reports, with a remarkable impact factor.
Discover the latest journals in Medical and Health Sciences
The primary function of medical articles is the validation of cutting-edge theoretical and clinical research, by providing reference and relevant forums. New drugs and medical practices can only enter the mainstream practise if their randomised trials had passed under the critical lens of prestigious peer reviewed journals. Technical reports help practitioners to improve their arsenal. Case reports confirm theories and provide tools for investigating or disclosing possible malpractice. Review articles serve educational purposes. Some more popular articles may play a role in educating the interested audience.
Types of medical articles
The papers published in medical journals can be classified in the following main categories
Research articles report about novel research results, of both theoretical and (direct or indirect) practical relevance.
Review articles survey specific topics by summarising and analysing all information available in the medical literature. Reviews are kind of combining results from different studies on the same topic. They can be useful for specialists in the field, may help them to prevent, diagnose, or treat a particular disease.
Case reports and case series reports about a concrete story of a concrete patient. They can be interesting because of their uniqueness, not matching any known diagnosis or describing unexpected symptoms. The report should describe each of the diagnosis, treatment, the patient’s response to it and the follow-up history. Case series are related reports about similarly treated patients.
Editorials are typically not peer reviewed shorter communications from senior members of the Editorial Board or from invited renown scholars. They discuss questions of relevance for the scientific community at the moment (say, about public health, or more generally, the health system).
Letters to the editor are articles of the interactive type, a form for readers to contact the medical journal. They can express comments, questions, or criticisms regarding some articles published in that journal. They provide a sophisticated forum for medical communities.
Medical Journals at AKJournals
AKJournals has 9 medical journals. Three of them are in Hungarian. The other six journals are in English and accept submissions from all over the world. Some of them are widely available Open Access journals. The covered topics include immunology, medical imaging, physiology, and veterinary and health care science. In these journals, you can find more than 11.000 medical articles altogether. A filter tool helps to single out the relevant titles. In addition to that, we highly recommend using the search box to find the most important topics only
Authors:Pál Soltész, Norbert Németh, Kristóf Gál, Melinda Vass, Ágnes Diószegi, Ferenc †Mechler, Klára Fekete, Viktória Somogyi, and László Módis
Összefoglaló.Háttér: A rheopheresis egy szelektív, extracorporalis, kettős
kaszkádfiltrációs eljárás, mely előzetes plazmaszeparációt követően egy
speciális filter segítségével kivonja a vérplazmából a hiperviszkozitásért
felelős komponenseket, úgymint alacsony sűrűségű lipoprotein, lipoprotein(a),
triglicerid, koleszterin, fibrinogén, α2-makroglobulin, Von Willebrand-faktor,
immunglobulin-M. Módszer és Betegek: Klinikánkon az elmúlt 5
évben MONET filter alkalmazásával összesen 80 kezelést végeztünk
hiperviszkozitással összefüggő, időskori száraz maculadegeneratióban, diabeteses
alsó végtagi fekélyben, illetve neuropathiában. Eredmények: A
dolgozatban beszámolunk kedvező klinikai tapasztalatainkról, a viszkozitás, a
klinikai tünetek és az elektroneurográfiai paraméterek tükrében. Orv Hetil.
2021; 162(10): 375–382.
Summary.Background: Rheopheresis is a selective, extracorporeal, double
cascade filtration method. After a previous plasma separation, with the help of
a special filter it extracts compounds from blood plasma which are responsible
for hyperviscosity such as low-density lipoprotein, lipoprotein(a),
triglyceride, cholesterine, fibrinogen, α2-macroglobulin, Von Willebrand factor,
immunoglobulin M. Method and Patients: In the past 5 years,
with the application of MONET filter we performed 80 therapies to treat
age-related macula degeneration, diabetic foot ulcers and neuropathy which are
complicated with hyperviscosity. Results: The review describes
our benefical clinical experiences in consideration of viscosity, clinical
symptoms and electroneurography parameters. Orv Hetil. 2021; 162(10):
Authors:György Losonczy, József Lukácsovits, Zoltán Süttő, András Lorx, and Veronika Müller
Összefoglaló. Számos közlemény született arról, hogy a
COVID–19-pneumoniás betegek jelentős hányadában az artériás parciális
oxigéntenzió kifejezetten alacsony, mégsem jellemző a dyspnoe, és a
pulzusoximetria sem mutat – a csökkent oxigéntenzióval arányos – súlyos
hypoxaemiát. A jelenséget „happy hypoxaemia” néven említik. Ugyanakkor a
légszomjról nem panaszkodó, de súlyos alveolocapillaris O2-felvételi
zavarban szenvedő COVID–19-pneumoniás betegek a legkisebb fizikai megterhelést
sem tűrik, és állapotuk gyorsan kritikussá válhat, tehát a hypoxaemia mértékének
időben való felismerése kulcskérdés. A jelen közleményben egy ilyen eset rövid
ismertetése után összefoglaljuk a súlyos, de tünetmentes hypoxaemia hátterében
meghúzódó élettani okokat. Ezek között szerepel a hypocapnia (respiratoricus
alkalosis) is, mely alacsony oxigéntenzió mellett is a hemoglobin viszonylag
megtartott oxigénszaturációját eredményezi. Ezért a mindennapi
COVID–19-ellátásban a megismételt artériásvérgáz-meghatározások jelentősége nem
hangsúlyozható eléggé. Orv Hetil. 2021; 162(10): 362–365.
Summary. Many COVID-19 patients have very low arterial partial
oxigen tension while severe dyspnoe does not develop. Pulse oxymetry indicates
only moderate reduction of arterial O2 saturation in these patients.
The phenomenon is named “happy hypoxaemia”. Lack of (severe) dyspnoe and only
moderately decreased O2 saturation in severely impaired
alveolo-capillary O2 uptake may partially be explained by an
increased oxygen affinity of hemoglobin in the presence of low arterial partial
pressure of CO2. The latter results from increased alveolar
ventilation, while low partial pressure of O2 in COVID-19 patients
reflects right-to-left shunting of pulmonary blood flow and
ventilation-perfusion mismatch of the diseased lungs. While such patients may
have mild complaints as related to the real impairment of alveolo-capillary
oxygen exchange, severe hypoxaemia is a negative prognostic factor of outcome in
this state where severe clinical deterioration may rapidly appear. The latter
circumstance together with the unusual relationship of O2 partial
pressure and O2 saturation of hemoglobin in COVID-19 emphasize the
importance of repeated complete arterial blood gas analyses in these patients.
Orv Hetil. 2021; 162(10): 362–365.
Authors:M. Kádár, G.J. Szőllősi, Sz. Molnár, L. Kardos, and L. Szabó
Understanding the role of nutrition in the development of children’s physical, mental, and motor abilities.
Examination of visiting nurse reports on feeding habits and perceived developmental delays in infants at 1 year of age between 2010 and 2015.
Between 0 and 6 months of age the lowest number of new cases (4.4/100,000) identified by health screenings can be anticipated among the infants feeding exclusively with breastmilk. We find a similarly low number of identifiable new cases among infants nourished with breastmilk where it is mixed with other nutrients (4.7 new cases) while the most cases of delayed motor development can be anticipated among infants nourished with infant formulae (48.4 new cases).
The role of nutrition in infants’ motor development is vital, especially breastfeeding. Regular health status checks of infants are inevitably required for the adoption of higher-level health-policy decisions which may induce projects, programmes, and strategies aimed at the improvement of health. Thorough documentation and continuous collection of the pertinent data is likewise requisite.
Authors:Elvan Hortaç İştar, Hikmet Eda Alışkan, and Jülide Sedef Göçmen
After the first description of OXA-48 type carbapenemase, it has become endemic in Europe, Mediterranean and North African countries in a short time. OXA-48 carbapenemase is the most difficult type to determine and accurate diagnosis is crucial especially in endemic areas.
The CarbaNP test was described as a rapid phenotypic evaluation method of carbapenemases activity. Sensitivity and specifity of this test were high within all carbapenemases genes. In our study, we evaluated the efficacy of CarbaNP test in routine laboratories located in an endemic area of OXA-48 producing Enterobacterales.
A total of 53 Enterobacterales isolates were included in this study. Antimicrobial susceptibility of the isolates to imipenem, meropenem and ertapenem was determined. Polymerase Chain Reaction (PCR) was carried out for the detection of carbapenemases genes (blaKPC, blaNDM,blaBIC,blaIMP,blaVIM, blaSPM,blaAIM,blaDIM,blaGIM,blaSIM, and blaOXA-48). The Carba NP test was performed as in the protocol described previously.
Altogether 31 isolates (58.4%) were blaOXA-48 positive (18 Klebsiella pneumoniae, 8 Escherichia coli, 2 Serratia marcescens, 1 Enterobacter aerogenes, 1 Pantoea agglomerans and 1 Morganella morganii). Among these isolates 3 (5.6%) and 2 (3.7%) isolates were also positive for blaVIM and blaSPM, respectively.
The sensitivity and specifity of CarbaNP test were found 64.5, and 68.2% respectively. It was observed that determination of positive isolates is hard to distinguish and subjective.
The CarbaNP test has suboptimal results and low of sensitivity and specifity for detection of OXA-48 producing Enterobacterales, and not suitable for detection of blaOXA-48 positive isolates in routine laboratories in endemic areas.
Authors:Κonstantina Kontopoulou, Georgios Meletis, Styliani Pappa, Sofia Zotou, Katerina Tsioka, Panagiota Dimitriadou, Eleni Antoniadou, and Anna Papa
Bacterial carbapenem resistance, especially when mediated by transferable carbapenemases, is of important public health concern. An increased number of metallo-β-lactamase (MBL)-producing Klebsiella pneumoniae strains isolated in a tertiary hospital in Thessaloniki, Greece, called for further genetic investigation.
The study included 29 non-repetitive carbapenem resistant K. pneumoniae isolates phenotypically characterized as MBL-producers collected in a tertiary hospital in Greece. The isolates were screened for the detection of carbapenemase genes (K. pneumoniae carbapenemase (blaKPC), Verona-integron-encoded MBL-1 (blaVIM-1), imipenemase (blaIMP), oxacillinase-48 (blaOXA-48) and New Delhi MBL (blaNDM)). The genetic relationship of the isolates was determined by Random Amplified Polymorphic DNA (RAPD) analysis. The whole genome sequences (WGS) from two NDM-positive K. pneumoniae isolates were further characterized.
The presence of New Delhi MBL (blaNDM) gene was confirmed in all K. pneumoniae isolates, while blaKPC and blaVIM-1 genes were co-detected in one and two isolates, respectively. The RAPD analysis showed that the isolates were clustered into two groups. The whole genome sequence analysis of two K. pneumoniae isolates revealed that they belonged to the sequence type 11, they carried the blaNDM-1 gene, and exhibited differences in the number and type of the plasmids and the resistant genes.
All MBL-producing K. pneumoniae isolates of the study harbored a blaNDM gene, while WGS analysis revealed genetic diversity in resistance genes. Continuous surveillance is needed to detect the emergence of new clones in a hospital setting, while application of antimicrobial stewardship is the only way to reduce the spread of multi-resistant bacteria.
Authors:Neslihan Arıcı, Sebahat Aksaray, and Handan Ankaralı
Bartonella henselae is the causative agent of cat scratch disease (CSD). In this study, we aimed to investigate the clinical data of patients with suspicion of CSD and delineate current epidemiological features.
A total of 785 patients with suspected CSD were included in the study. B. henselae IgM antibody was determined by indirect fluorescent antibody (IFA) test using a commercial kit (Euroimmun, Germany). Sex, age, clinical pre-diagnosis and animal contact information of the patients were obtained from hospital electronic database records.
Seventy-eight (9.9%) of 785 samples were seropositive. Out of 78 patients, 46 with animal contact data were further analyzed. Of these patients, 56% were male, and 41% were under 18 years of age. Seropositivity was more commonly observed in fall and winter. The most common finding was lymphadenitis (63%). Thirty-five patients (76%) had a previous history of animal contact (cat/dog). Of the 46 seropositive patients, 78.3, 15.2, 4.4, and 2.1% had titers of 1:80, 1:160, 1:320, and 1:640, respectively.
Our study confirms that CSD is not rare in Turkey. Thus, it should always be considered in the differential diagnosis of patients presenting with lymphadenopathy in all age groups, particularly children. Questioning of cat exposure should never be neglected, especially in areas with intense population of stray cats, such as Istanbul.
Authors:Saša Koprivec, Marko Novak, Stanislav Bernik, Metka Voga, Luka Mohorič, and Gregor Majdič
In the present pilot study, we evaluated different supplemental therapies using autologous multipotent mesenchymal stromal cells (MMSCs) for the treatment of cranial cruciate ligament defects in dogs. We used tibial tuberosity advancement (TTA) and augmented it by supportive therapy with MMSCs in three patient groups. In the first patient group, the dogs were injected with MMSCs directly into the treated stifle one month after surgery. In the second group, MMSCs were delivered in a silk fibroin scaffold which was placed in the osteotomy gap during surgery. In the third group, MMSCs were first mixed with bone tissue and blood from the patient and delivered into the osteotomy gap during surgery. In the control group, patients underwent the TTA procedure but did not receive MMSC treatment. In the group of patients who received cells in the silk fibroin scaffold during surgery, the osteotomy gap did not heal, presumably due to the low absorption of silk fibroin. Patients who received MMSCs mixed with bone tissue and blood during surgery into the osteotomy gap recovered clinically faster and had better healing of the osteotomy gap than dogs from the other two treated groups and from the control group, as assessed by clinical examination and quantification of radiographs. In conclusion, dogs that received stem cells directly into the osteotomy gap (Group 3) recovered faster compared to dogs from Groups 1 (MMSCs injected into the joint one month after surgery), 2 (cells implanted into the osteotomy gap in a silk fibroin scaffold), and the control group that did not receive additional MMSCs treatment.
Authors:Joana Korablioviene, Mykolas Mauricas, Irena Dumalakiene, Saulius Caplinskas, Rita Viliene, Justinas Baleisis, Gintautas Vysniauskis, Joanna Chorostowska-Wynimko, Ginreta Magelinskiene, Pavel Korabliov, and Arunas Valiulis
This study investigated BCG masking dependency on the species of Mycobacterium through the immune response to the mycobacterial region of deletion 1 (RD-1) associated growth affecting proteins (GEP).
To evaluate the effects of GEP, 8-week old female BALB/c mice were immunized with either the wild type Mycobacterium bovis (MBGEP) or the ATCC Mycobacterium avium subsp. avium (MAGEP) strain and then subjected to further exposure with Mycobacterium terrae or M. avium sub. avium. Mice immunized with MAGEP and those mice further exposed to M. avium subsp. avium had increased granulocytes (GRA) and monocytes to lymphocytes rate (MLR) compared to control mice. Immunization of mice with GEP induced an antibody response one month after primary immunization, as observed by cross-reactivity. Our findings suggest that MAGEP is related to a latent hypersensitivity reaction and an increased risk of mycobacterial infection susceptibility. According to the results of the present study, previous sensitization with NTM antigens results in varying immune reactions after contact with different NTM argued that masking phenomena may be dependent on the species of Mycobacterium.
Authors:Imre Rurik, Péter Apor, Mária Barna, István Barna, J. Róbert Bedros, Péter Kempler, Éva Martos, Elemér Mohos, Gábor Pavlik, Gyula †Pados, József Pucsok, Gábor Simonyi, and György Bíró
Összefoglaló. Az elhízás és következményes megbetegedései fontos
népegészségügyi problémát jelentenek hazánkban is. Kezelése komoly szakmai
kihívás, ugyanakkor prevenciója eredményesebb lehet. Az elhízott betegekkel
leggyakrabban találkozó háziorvosok, más szakorvosok és egészségügyi szakemberek
részéről nagy igény van egy viszonylag rövid, áttekinthető, naprakész
gyakorlatias útmutatóra. A különböző orvosszakmai társaságokban tevékenykedő,
évtizedes szakmai tapasztalatokkal rendelkező szerzők összefoglalják
tudományosan megalapozott, bizonyítékokon alapuló ismereteiket. Az elhízás
kezelését lépcsőzetesen célszerű megkezdeni, előtte felmérve a beteg
motivációját, általános állapotát, lehetőségeit. A szerzők leírják az
energiaszükséglet meghatározásával, az étrenddel és a fizikai aktivitás
megtervezésével kapcsolatos alapvető szempontokat. Felsorolják a hazánkban
elérhető gyógyszereket és metabolikus sebészeti beavatkozásokat, az életmódi
támogatás igényét. Az elhízás megelőzésében az élet első 1000 napjának
táplálkozása, a későbbiekben a szülői minta a meghatározó. Sok kihasználatlan
lehetősége van a háziorvosok, a lakóközösségek, az állami szervek koordinált
együttműködésének, helyi kezdeményezéseknek. Az elhízás betegségként való
meghatározása egyaránt igényel egészségpolitikai és kormányzati támogatást, az
elhízottak ellátására szakosodott multidiszciplináris centrumok számának és
kompetenciájának növelését. Orv Hetil. 2021; 162(9): 323–335.
Summary. Obesity and related morbidities have a high public health
impact in Hungary. The treatment is a challenge, but prevention seems more
effective. General practitioners, other specialists and health care
professionals who are treating obese persons require short, summarized, updated
and practical guideline. Hungarian medical professionals of different scientific
societies, having decennial practices, are summarizing their evidence-based
knowledge. Obesity management requires step by step approach, evaluating
previously the general health condition, motivation and options of the patients.
The measurement of energy requirement, planning of diet and physical activities,
available surgical methods and medications are described in detail with life
style and mental support needed. The most important period in the prevention of
obesity is the first 1000 days from conception. Other significant factors are
the life style habits of the parents. Proper obesity prevention requires better
coordination of primary health care, community and governmental activities.
Obesity should be defined as morbidity, therefore stronger governmental support
and more health-policy initiatives are needed, beside increasing number and
developing of multidisciplinary centres. Orv Hetil. 2021; 162(9): 323–335.