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Browse our Medical Journals
Among all scientific traditions alive, medical publishing has a good chance to be the oldest. The first fully peer reviewed academic journal, “Medical Essays and Observations” was launched in 1731 by the Royal Society in Edinburgh. Since then, hundreds of medical journals have been published worldwide. Medical publication in Hungary started in 1857 when the famous physician, Markusovszky founded “Orvosi Hetilap”, which has been published since then every week (with short breaks during the world wars). It is now a most prestigious piece in AKJournals’ portfolio, listed in Journal Citation Reports, with a remarkable impact factor.
Discover the latest journals in Medical and Health Sciences
The primary function of medical articles is the validation of cutting-edge theoretical and clinical research, by providing reference and relevant forums. New drugs and medical practices can only enter the mainstream practise if their randomised trials had passed under the critical lens of prestigious peer reviewed journals. Technical reports help practitioners to improve their arsenal. Case reports confirm theories and provide tools for investigating or disclosing possible malpractice. Review articles serve educational purposes. Some more popular articles may play a role in educating the interested audience.
Types of medical articles
The papers published in medical journals can be classified in the following main categories
Research articles report about novel research results, of both theoretical and (direct or indirect) practical relevance.
Review articles survey specific topics by summarising and analysing all information available in the medical literature. Reviews are kind of combining results from different studies on the same topic. They can be useful for specialists in the field, may help them to prevent, diagnose, or treat a particular disease.
Case reports and case series reports about a concrete story of a concrete patient. They can be interesting because of their uniqueness, not matching any known diagnosis or describing unexpected symptoms. The report should describe each of the diagnosis, treatment, the patient’s response to it and the follow-up history. Case series are related reports about similarly treated patients.
Editorials are typically not peer reviewed shorter communications from senior members of the Editorial Board or from invited renown scholars. They discuss questions of relevance for the scientific community at the moment (say, about public health, or more generally, the health system).
Letters to the editor are articles of the interactive type, a form for readers to contact the medical journal. They can express comments, questions, or criticisms regarding some articles published in that journal. They provide a sophisticated forum for medical communities.
Medical Journals at AKJournals
AKJournals has 9 medical journals. Three of them are in Hungarian. The other six journals are in English and accept submissions from all over the world. Some of them are widely available Open Access journals. The covered topics include immunology, medical imaging, physiology, and veterinary and health care science. In these journals, you can find more than 11.000 medical articles altogether. A filter tool helps to single out the relevant titles. In addition to that, we highly recommend using the search box to find the most important topics only
Authors:Bence Kozma, Krisztina Pákozdy, Rudolf Lampé, Ervin Berényi, and Péter Takács
Összefoglaló. Az ultrahang-elasztográfia az elmúlt évek során egyre
növekvő figyelmet kapott a lágyszövetek elaszticitásának vizsgálatában. A
módszer használatát az teszi szükségessé, hogy egyes, a mechanikai
tulajdonságaikban különböző szövetek hasonló echogenitásúak lehetnek, valamint
hogy egy adott szövet megváltozott struktúrája vagy mechanikai tulajdonsága nem
minden esetben jár együtt a szövet hagyományos ultrahangképének megváltozásával.
Az elmúlt évtizedben a deformációs és a nyírási ultrahang-elasztográfia vált
széles körben elérhetővé. Ezen új képalkotási technika egyre nagyobb szerepet
tölt be a szülészeti-nőgyógyászati ultrahang-diagnosztikában is. A
nőgyógyászatban szerephez juthat az endometriosis és az adenomyosis
kimutatásában, valamint a benignus és a malignus cervicalis és ovarialis
képletek elkülönítésében. A nőgyógyászathoz hasonlóan a szülészetben is jelentős
változást hozhat az ultrahang-elasztográfia: alkalmas lehet a szülésindukció
sikerességének, a koraszülés bekövetkezésének és a praeeclampsia kialakulásának
előrejelzésére. Orv Hetil. 2021; 162(18): 690–695.
Summary. Ultrasound elastography has received significant attention
for the assessment and measurement of soft tissue elastic properties in recent
years. The advantage of ultrasound elastography lies in the fact that two
different tissues can share similar echogenicities but may have other mechanical
properties or, on the contrary, mechanical abnormalities of a designated tissue
do not necessarily go hand in hand with an altered appearance on a conventional
ultrasound image. In the last decade, strain and shear-wave elasticity imaging
methods have become the most widely available among commercial ultrasound
equipments. The importance of this new method expands rapidly also in the field
of obstetrics and gynecology. Ultrasound elastography has a promising role in
the diagnosis of endometriosis and adenomyosis and helps to differentiate benign
and malignant cervical and ovarian lesions. The use in the prediction of the
outcome of labor induction and preterm birth, and in the evaluation of
preeclampsia are emerging. Orv Hetil. 2021; 162(18): 690–695.
Authors:Zsuzsanna Antus, Olga Lukáts, Irén Szalai, Zoltán Zsolt Nagy, and Nóra Szentmáry
Összefoglaló.Bevezetés: Szemhéjcsüngésnek (ptosis vagy blepharoptosis)
nevezzük azt az állapotot, amikor a felső szemhéj abnormálisan alacsony
pozícióban van. A szemhéjcsüngésnek lehetnek veleszületett és szerzett formái.
Célkitűzés: Célunk volt bemutatni a szemhéjemelő izom
(levator) – veleszületett szemhéjcsüngés korrekciója céljából végzett –
kötőhártya felőli redőzésének eredményeit retrospektív módszerrel.
Módszer: 20 beteg 22 szemhéján végeztük el a műtétet
(átlagéletkor: 19,4 ± 9,9 év, férfi: 12 [60%], nő: 8 [40%]). Beválasztási
kritérium volt a közepes (5–8 mm) vagy jó (9 mm felett) levatorfunkció. Kizártuk
a korábban szemhéjkorrekciós műtéten átesett és a 3 hónapnál rövidebb követési
idővel rendelkező betegeket. A műtét előtt megmértük a levatorfunkciót és a
margó–reflex-távolságot. A műtét után megmértük a margó–reflex-távolságot, a
szemhéjak magassága közti aszimmetria mértékét, és elemeztük a szemhéj
posztoperatív kontúrját. Eredmények: A preoperatív
levatorfunkció 10,6 ± 3,0 mm, a preoperatív margó–reflex-távolság 1,8 ± 0,8 mm
volt. A 7,8 ± 7,2 hónap átlagos követési idő alatt a posztoperatív
margó–reflex-távolság 3,2 ± 0,8 mm volt. A preoperatív és a posztoperatív
margó–reflex-távolság különbsége nem tért el szignifikánsan a sikeres és a
sikertelen műtétek között (p = 0,523). A szemhéjak magassága közti aszimmetria
mértéke 3 betegnél haladta meg az 1 mm-t. A szemhéj posztoperatív kontúrja
minden esetben megfelelő volt. A műtét összességében 86,4%-ban (19/22) volt
sikeres. A helyi érzéstelenítésben és altatásban végzett műtétek közt nem
találtunk szignifikáns különbséget a sikeresség tekintetében (p = 0,227).
Következtetés: Tanulmányunk alapján az elvégzett műtéteink
eredményessége a nemzetközi irodalomban közöltekhez hasonló volt. A
veleszületett szemhéjcsüngés korrekciójára a kötőhártya felőli levatorredőzés
megfelelő kezelési mód közepes vagy annál jobb levatorfunkció esetén. Orv Hetil.
2021; 162(18): 705–711.
Summary.Introduction: Droopy eyelid (ptosis or blepharoptosis) is
defined through abnormally low upper eyelid position. Ptosis can be classified
as congenital or acquired. Objective: Our purpose was to report
the results of posterior approach levator plication for congenital ptosis in a
retrospective review. Method: 22 eyelids of 20 patients were
included in this study (age: 19.4 ± 9.9 years, male: 12 [60%], female: 8 [40%]).
The inclusion criteria were moderate (5–8 mm) or good (more than 9 mm) levator
function. Patients with postoperative follow-up time shorter than 3 months and
those who underwent previous eyelid surgery were excluded. The data collected
included preoperative levator function and margin reflex distance, postoperative
margin reflex distance, inter-eyelid height asymmetry and postoperative eyelid
contour. Results: Preoperative levator function was 10.6 ± 3.0
mm, preoperative margin reflex distance was 1.8 ± 0.8 mm. During 7.8 ± 7.2
months postoperative follow-up, postoperative margin reflex distance was 3.2 ±
0.8 mm. The difference between preoperative and postoperative margin reflex
distance was not significant (p = 0.523) in the group of successful operations
compared with unsuccessful operations. Inter-eyelid height asymmetry was more
than 1 mm in 3 cases. Satisfactory postoperative eyelid contour was achieved in
all cases. Overall success rate was 86.4% (19/22). Surgical success did not
differ significantly between surgeries in local or general anaesthesia (p =
0.227). Conclusion: Our study shows an overall success rate of
the procedures comparable to those in international publications. Posterior
approach levator plication for congenital ptosis with moderate or better levator
function seems to be a suitable treatment method. Orv Hetil. 2021; 162(18):
Authors:Thomas Heseltine, Scott W Murray, Saye Khoo, and Balazs Ruzsics
The treatment of human immunodeficiency virus (HIV) with antiretroviral (ARV) medications has revolutionised the care for these patients. The dramatic increase in life expectancy has brought new challenges in treating diseases of aging in this cohort. Cardiovascular disease (CVD) is now a leading cause of morbidity and mortality with risk matched HIV-positive patients having double the risk of MI compared to HIV-negative patients. This enhanced risk is secondary to the interplay the virus (and accessory proteins), ARV medications and traditional risk factors. The culmination of these factors can lead to a hybrid metabolic syndrome characterised by heightened ectopic fat . Cardiovascular computed tomography (CT) is ideal for quantifying epicardial adipose tissue volumes, hepatosteatosis and cardiovascular disease burden. The CVD risk attributed to disease burden and plaque morphology is well established in general populations but is less clear in HIV populations. The purpose of this review article is to appraise the latest data on CVD development in HIV-positive patients and how the use of cardiovascular CT may be used to enhance risk prediction in this population. This may have important implications on individualised treatment decisions and risk reduction strategies which will improve the care of these patients.
Authors:Bettina Katalin Budai, Veronica Frank, Sonaz Shariati, Bence Fejér, Ambrus Tóth, Vince Orbán, Viktor Bérczi, and Pál Novák Kaposi
Artificial Intelligence and the use of radiomics analysis have been of great interest in the last decade in the field of imaging. CT texture analysis (CTTA) is a new and emerging field in radiomics, which seems promising in the assessment and diagnosis of both focal and diffuse liver lesions. The utilization of CTTA has only been receiving great attention recently, especially for response evaluation and prognostication of different oncological diagnoses. Radiomics, combined with machine learning techniques, offers a promising opportunity to accurately detect or differentiate between focal liver lesions based on their unique texture parameters. In this review article, we discuss the unique ability of radiomics in the diagnostics and prognostication of both focal and diffuse liver lesions. We also provide a brief review of radiogenomics and summarize its potential role of in the non-invasive diagnosis of malignant liver tumors.
Authors:Veronica Frank, Sonaz Shariati, Bettina Katalin Budai, Bence Fejér, Ambrus Tóth, Vince Orbán, Viktor Bérczi, and Pál Novák Kaposi
It has been proven in a few early studies that radiomic analysis offers a promising opportunity to detect or differentiate between organ lesions based on their unique texture parameters. Recently, the utilization of CT texture analysis (CTTA) has been receiving significant attention, especially for response evaluation and prognostication of different oncological diagnoses. In this review article, we discuss the unique ability of radiomics and its subfield CTTA to diagnose lesions in the pancreas and kidney. We review studies in which CTTA was used for the classification of histology grades in pancreas and kidney tumors. We also review the role of radiogenomics in the prediction of the molecular and genetic subtypes of pancreatic tumors. Furthermore, we provide a short report on recent advancements of radiomic analysis in predicting prognosis and survival of patients with pancreatic and renal cancers.
Authors:Nilgün Gültiken, Murat Yarim, Gül Fatma Yarim, Mahmut Sözmen, Elvan Anadol, and Murat Findik
The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)–pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. IGF-2 immunopositivity was observed in the endometrial glandular epithelium in both groups. Additionally, interstitial fibroblasts and macrophages in the endometrium were also positive in Group 1. The concentration of plasma IGF-2 was higher in Group 1 than in Group 2 (P < 0.05). The concentration was positively correlated with IGF-2 expression in the endometrial glands (r = 0.926; P < 0.001) in Group 1. However, a negative correlation was present between plasma IGF-2 concentration and IGF-2 expression in the interstitial endocrine cells of the ovary in Group 1 (r = −0.652; P < 0.05). The results suggest that IGF-2 plays an important role during the inflammatory process occurring in bitches with CEH–pyometra complex as well as in the endometrium of healthy bitches in dioestrus.
Authors:Violetta M. Yurakhno, Vladimir N. Voronin, Sergey G. Sokolov, Julia M. Malysh, Alexandr P. Kalmykov, and Yuri S. Tokarev
Loma acerinae is a xenoma-forming fish microsporidium described from common ruffe Gymnocephalus cernua (Perciformes: Percidae) and also found in Ponto-Caspian gobies (Gobiiformes: Gobiidae). This casts doubt on the strict host specificity of this parasite. The largest subunit RNA polymerase II (rpb1) was used as a genetic marker of the parasite isolated from six host species of Perciformes (G. cernua from the Baltic Sea), Atheriniformes (Atherina boyeri from the Azov Sea) and Gobiiformes (Neogobius spp. and Zosterisessor ophiocephalus from the Black Sea and Ponticola kessleri from the Caspian Sea basin). Two major rpb1 haplogroups were found with 98.5% identity between the groups. Notably, Haplogroup I was associated with Neogobius spp. samples (n = 6) only, whereas Haplogroup II included the samples from other host species (n = 7). These findings confirm the broad distribution and host range of L. acerinae, but also indicate that certain patterns of host-driven intraspecific polymorphism may exist. Furthermore, the study revealed low similarity between the ribosomal RNA gene sequences of L. acerinae and the type species, Loma morhua (as well as other species of the genus). This suggests loose genetic association within the genus, and may raise the need for the taxonomic revision of L. acerinae.
Interferon-induced transmembrane protein 3 (IFITM3) plays a pivotal role in antiviral capacity in several species. However, to date, investigations of the IFITM3 protein in cattle have been rare. According to recent studies, interspecific differences in the IFITM3 protein result in several unique features of the IFITM3 protein relative to primates and birds. Thus, in the present study, we investigated the bovine IFITM3 protein based on nucleotide and amino acid sequences to find its distinct features. We found that the bovine IFITM3 gene showed a significantly different length and homology relative to other species, including primates, rodents and birds. Phylogenetic analyses indicated that the bovine IFITM3 gene and IFITM3 protein showed closer evolutionary distance with primates than with rodents. However, cattle showed an independent clade among primates, rodents and birds. Multiple sequence alignment of the IFITM3 protein indicated that the bovine IFITM3 protein contains 36 bovine-specific amino acids. Notably, the bovine IFITM3 protein was predicted to prefer inside-to-outside topology of intramembrane domain 1 (IMD1) and inside-to-outside topology of transmembrane domain 2 by TMpred and three membrane embedding domains according to the SOSUI system.