Among all scientific traditions alive, medical publishing has a good chance to be the oldest. The first fully peer reviewed academic journal, “Medical Essays and Observations” was launched in 1731 by the Royal Society in Edinburgh. Since then, hundreds of medical journals have been published worldwide. Medical publication in Hungary started in 1857 when the famous physician, Markusovszky founded “Orvosi Hetilap”, which has been published since then every week (with short breaks during the world wars). It is now a most prestigious piece in AKJournals’ portfolio, listed in Journal Citation Reports, with a remarkable impact factor.
Discover the latest journals in Medical and Health Sciences
The primary function of medical articles is the validation of cutting-edge theoretical and clinical research, by providing reference and relevant forums. New drugs and medical practices can only enter the mainstream practise if their randomised trials had passed under the critical lens of prestigious peer reviewed journals. Technical reports help practitioners to improve their arsenal. Case reports confirm theories and provide tools for investigating or disclosing possible malpractice. Review articles serve educational purposes. Some more popular articles may play a role in educating the interested audience.
Types of medical articles
The papers published in medical journals can be classified in the following main categories
Research articles report about novel research results, of both theoretical and (direct or indirect) practical relevance.
Review articles survey specific topics by summarising and analysing all information available in the medical literature. Reviews are kind of combining results from different studies on the same topic. They can be useful for specialists in the field, may help them to prevent, diagnose, or treat a particular disease.
Case reports and case series reports about a concrete story of a concrete patient. They can be interesting because of their uniqueness, not matching any known diagnosis or describing unexpected symptoms. The report should describe each of the diagnosis, treatment, the patient’s response to it and the follow-up history. Case series are related reports about similarly treated patients.
Editorials are typically not peer reviewed shorter communications from senior members of the Editorial Board or from invited renown scholars. They discuss questions of relevance for the scientific community at the moment (say, about public health, or more generally, the health system).
Letters to the editor are articles of the interactive type, a form for readers to contact the medical journal. They can express comments, questions, or criticisms regarding some articles published in that journal. They provide a sophisticated forum for medical communities.
Medical Journals at AKJournals
AKJournals has 9 medical journals. Three of them are in Hungarian. The other six journals are in English and accept submissions from all over the world. Some of them are widely available Open Access journals. The covered topics include immunology, medical imaging, physiology, and veterinary and health care science. In these journals, you can find more than 11.000 medical articles altogether. A filter tool helps to single out the relevant titles. In addition to that, we highly recommend using the search box to find the most important topics only
Authors:András Mohos, Albert Varga, Csenge Hargittay, Dalma Csatlós, László Kalabay, and Péter Torzsa
Összefoglaló.Bevezetés: A családorvosok testi, lelki egészségi állapota
hatással van a munkavégzésükre, a betegellátás minőségére, ezáltal a társadalom
egészségmutatóira is. Az életmód pedig az egyik legjelentősebb, egészségi
állapotot befolyásoló tényező. Célkitűzés: A vizsgálat célja a
magyar háziorvosok egészségi állapotának és az azt befolyásoló
életmódtényezőknek a felmérése. Módszer: Keresztmetszeti
vizsgálat. Kvantitatív, papíralapú felmérés családorvosok körében (n = 569,
életkor 54 ± 10 év, nők 42%). Eredmények: A háziorvosok 61%-a
túlsúlyos vagy elhízott, 88%-ának a vércukorszintje ≤5,5 mmol/l. A résztvevők
50%-a legalább heti rendszerességgel végez testmozgást, 20%-uk egyáltalán nem. A
háziorvosok 13%-a dohányzik jelenleg, 5%-a tekinthető nagyivónak. Enyhe fokú
depressziós tünetegyüttes 19%-uknál, közepes fokú 6%-uknál, súlyos fokú 5%-uknál
fordult elő. A súlyos fokú kiégés mindkét nemben, mindhárom dimenzióban 18–39%
volt. Következtetés: A magyar háziorvosok általános egészségi
állapota nem mondható jobbnak sem a hazai nem orvos populációénál, sem a
külföldi orvoskollégákénál. A magyar háziorvosok dohányzási mutatói kedvezőbbek
a lakossági adatoknál, míg az alkoholfogyasztás terén kedvezőtlenebb
eredményeket kaptunk. Nemzetközi összehasonlításban, a káros szenvedélyek terén
a hazai kollégák eredményei jónak tekinthetők. A depresszió és a kiégés gyakori
előfordulása jelentős probléma a háziorvosok körében. Mentális egészségük
monitorozása és gondozása a hatékony egészségügyi ellátórendszer kulcskérdése.
Orv Hetil. 2021; 162(12): 449–457.
Summary.Introduction: General practitioners’ somatic and mental health
status have an impact on their work and the quality of care they provide and
thus influence the health indicators of the society. Lifestyle is one of the
most important influencing factors of health. Objective: The
study aims to assess the health status of Hungarian general practitioners and
the lifestyle factors influencing it. Method: Cross-sectional
study. Quantitative, paper-based questionnaire among general practitioners (n =
569, age 54 ± 10 years, female 42%). Results: 61% of family
physicians are overweight or obese, 88% of them have blood glucose level ≤5.5
mmol/l. 50% of the participants do exercise at least once a week, 20% do not
take any exercise at all. 13% currently smoke, 7% are considered heavy drinkers.
Mild, moderate and severe depression symptoms occurred in 19%, 6% and 5% of
them, respectively. A severe level of burnout syndrome was reported in 18–39% in
both sexes, in all three dimensions. Conclusion: The health
status of Hungarian general practitioners is not better than that of the
non-medical Hungarian population or than that of foreign colleagues. The smoking
indicators of Hungarian doctors are more favorable than the Hungarian population
data, while we obtained worse results in the field of alcohol consumption. In
international comparison, the results of Hungarian colleagues in the field of
smoking and alcohol consumption are good. The frequent occurrence of depression
and burnout is a significant problem among family physicians. Monitoring and
caring for their mental health is a key factor in the effective health care
system. Orv Hetil. 2021; 162(12): 449–457.
Authors:R. Afroundeh, P. Hofmann, S. Esmaeilzadeh, M. Narimani, and A.J. Pesola
We examined the agreement between heart rate deflection point (HRDP) variables with maximal lactate steady state (MLSS) in a sample of young males categorized to different body mass statuses using body mass index (BMI) cut-off points. One hundred and eighteen young males (19.9 ± 4.4 years) underwent a standard running incremental protocol with individualized speed increment between 0.3 and 1.0 km/h for HRDP determination. HRDP was determined using the modified Dmax method called S.Dmax. MLSS was determined using 2-5 series of constant-speed treadmill runs. Heart rate (HR) and blood lactate concentration (La) were measured in all tests. MLSS was defined as the maximal running speed yielding a La increase of less than 1 mmol/L during the last 20 min. Good agreement was observed between HRDP and MLSS for HR for all participants (±1.96; 95% CI = −11.5 to +9.2 b/min, ICC = 0.88; P < 0.001). Good agreement was observed between HRDP and MLSS for speed for all participants (±1.96; 95% CI = −0.40 to +0.42 km/h, ICC = 0.98; P < 0.001). The same findings were observed when participants were categorized in different body mass groups. In conclusion, HRDP can be used as a simple, non-invasive and time-efficient method to objectively determine submaximal aerobic performance in nonathletic young adult men with varying body mass status, according to the chosen standards for HRDP determination.
We aimed to critically review the available information on the potential contribution of excessive kallikrein-kinin systems (KKSs) activation to severe respiratory inflammation in SARS-CoV-2 infection, and the likely consequence of ACE inhibition in seriously affected patients.
The literature related to the above topic was reviewed including papers that analysed the connections, actions, interactions, consequences and occasionally suggestions for rational interventions.
Severe broncho-alveolar inflammation seems to be caused, at least in part, by upregulation of the KKS that increases plasma and/or local tissue concentrations of bradykinin (BK) in patients with COVID-19 infection. Besides KKS activation, suppression of ACE activity results in decreased bradykinin degradation, and these changes in concert can lead to excessive BK B1 and B2 receptor (BKB1R/BKB2R) activation. Aminopeptidase P (APP), and carboxypeptidase N also degrade bradykinin, but their protein expression and activity are unclear in COVID-19 infection. On the other hand, ACE2 expression is upregulated in patients with COVID-19 infection, so ACE2 activity is unlikely to be decreased despite blockade of part of ACE2 by the virus for entry into the cells. ACE2 cleaves lys-des-arginine9BK and arg-des-arginine9BK, the active metabolites of bradykinin, which stimulate the BKB1R receptor. Stimulation of BKB1R/BKB2R can exacerbate the pulmonary inflammatory response by causing vascular leakage and edema, vasodilation, smooth muscle spasm and stimulation of pain afferent nerves. Despite all uncertainties, it seems rational to treat comorbid COVID patients with serious respiratory distress syndrome with ARBs instead of high-dose ACE inhibitor (ACEi) that will further decrease bradykinin degradation and enhance BKB1R/BKB2R activation, but ACEi may not be contraindicated in patients with mild pulmonary symptoms.
Reducing the risk of developing chronic disease, such as obesity and type 2 diabetes, is an important component of successful aging. Offspring born to mothers who exercise during pregnancy have improved body composition and metabolic profiles. However, mechanisms to explain this phenomenon are lacking.
This study examined whether maternal step counts were correlated with neonatal gene expression markers related to glucose metabolism and adipogenesis.
Physical activity levels were assessed in women with male neonates via Fitbit Flex® during the second and third trimester of pregnancy. The dartos and epidermal/dermal layers of the foreskin were collected following circumcision in full-term, singleton, neonates (n = 12 dartos and n = 14 dermal). Tissue was homogenized, RNA isolated, and a NanoString code set was run to quantify a panel of genes related to glucose metabolism and adipogenesis.
Twelve genes were correlated to steps per day with a P-value of <0.05. After adjusting for multiple comparisons, six genes remained significantly correlated to steps per day (False Discovery Rate-corrected P-value < 0.10). Notably, glucose transporter 1, adiponectin receptor 1, and CCAAT/enhancer-binding protein alpha and beta were positively correlated with steps per day, while peroxisome proliferator-activated receptor alpha and peroxisome proliferator-activated receptor gamma coactivator 1- alpha were negatively correlated with steps per day.
Maternal physical activity is associated with offspring gene expression markers of adipogenesis, insulin sensitivity and glucose uptake. Future studies should aim to mechanistically examine whether these markers are driving increased adiposity in offspring born to sedentary mothers.
Brain samples were collected from 33 animals of different species, including buffalo, cattle, dog, donkey, fox and wolf, that had been suspected to be infected by rabies virus (RABV) in different geographical regions of Aswan and Luxor governorates in Egypt. The samples were submitted for histopathological examination and the presence of the nucleic acid and antigens of RABV was tested by RT-PCR and indirect fluorescent antibody technique (IFAT), respectively. Sixteen samples were found positive by all the three examinations. Three samples were selected for further study from animals in which the highest virus loads were detected. The partial sequence of the RABV N gene was determined and analysed from the samples of a buffalo, a cow and a donkey. The viruses in the samples were found to share 95–98% and 95–97% nucleotide and amino acid sequence identities, respectively. In comparison to reference sequences, a few amino acid substitutions occurred in the N protein antigenic sites I and IV in the immunodominant epitopes of the viruses detected in the cow and the donkey but not in the one from the buffalo. The phylogenetic analysis revealed that the RABVs sequenced from the samples belonged to genotype 1, Africa-4 clade, and formed two distinct sub-clades within the Egyptian clade. These findings indicate the circulation of RABV among livestock animals in the southern part of Egypt and raise public health concerns. The amino acid changes detected in this work may contribute to the antigenic diversification of RABVs.
Authors:Pegah Safaei, Gholamhossein Khadjeh, Mohammad Reza Tabandeh, and Keramat Asasi
Sudden death syndrome (SDS) is an economically important disorder in broiler chickens with unknown aetiology. The aim of the present study was to evaluate the metabolic and molecular alterations related to hypoxia in the myocardium of broiler chickens with SDS. Samples from the cardiac muscle of internal control broiler chickens (ICs) (n = 36) and chickens having died of SDS (n = 36) were obtained during the rearing period. The activities of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) and the concentration of lactate were measured in the cardiac tissue using available commercial kits. The expression of hypoxia-inducing factor 1α (HIF1α), glucose transporter 1 (GLUT1), pyruvate dehydrogenase kinase 4 (PDHK4) and monocarboxylate transporter 4 (MCT4) genes was determined in the myocardium by real-time PCR analysis. The results showed the elevation of lactate level and activities of LDH and CPK in the cardiac muscle of SDS-affected chickens compared with the IC birds (P < 0.05). The cardiac muscle expression of HIF1α, MCT4 and GLUT1 genes was increased, while the PDHK4 mRNA level was decreased in the SDS-affected group compared to those in the IC chickens (P < 0.05). Our results showed that metabolic remodelling associated with hypoxia in the cardiac tissues may have an important role in the pathogenesis of cardiac insufficiency and SDS in broiler chickens.
Authors:Csaba Dzsinich, László Szentpétery, Gabriella Nagy, Tibor Pataki, Gábor Darabos, and László Barta
Összefoglaló. Complex aortaaneurysmáról beszélünk, ha az több,
egymástól anatómiailag nem elválasztható aortaszegmentumra terjed, és/vagy az
aneurysma egy vagy több életfontosságú mellékág szájadékát is magában foglalja.
Kettős vagy többszörös aortaaneurysmák egymástól sebészileg jól szeparálható
elváltozásokat jelentenek. Míg a complex elváltozások egy ülésben vagy időben,
egymást néhány nappal követő beavatkozással kezelendők, addig a
kettős/többszörös aneurysmák szeparált megoldásokkal uralhatók. E kiterjedt
elváltozások kezelése jelentős javallati és technikai kihívásokkal társul. A
kezelési lehetőségek széles spektrumával rendelkezünk. Korábban a nagy sebészi
traumával, jelentős morbiditással és mortalitással járó nyitott műtétek nagy
rizikóval terhelt betegeken siker reményében nem voltak elvégezhetők.
Napjainkban a sebészi és endograft technikákkal végzett hybrid műtétek, illetve
a tisztán endovascularis megoldások a kiterjedt elváltozások kezelésének
javallatát jelentősen kiszélesítették. Dolgozatunkban ismertetjük a lehetséges,
és az általunk már alkalmazott technikákat, valamint azokat a lehetőségeket,
amelyeket a rohamos technikai fejlődés kínál.
Summary. Complex aortic aneurysms extend to more aortic segments,
and/or include one or more orifices of highly important side branches. Meanwhile
complex aneurysms need reconstructive solutions in one sitting or hybrid
procedures timely close to each other, multiple aneurysms can be treated
technically and timely separated. Previously, open surgery was the only
opportunity to intervene, which was associated with significant surgical trauma
and was not suitable for high risk patients when devastating complications were
likely. Recently combination of lower risk surgery with endovascular treatment
options – the so called hybrid techniques – resulted in that indications for
treatment remarkably widened. In addition, permanent technical progress made
available pure endovascuar solutions, so a wide range of surgical procedures
provide number of options for treatment. In this paper we report on the
treatment options of complex aortic aneurysms, and present our own relevant
Authors:Tamás Molnár F., Péter Zsoldos, and Attila Oláh
Összefoglaló. A szerzők a sebészeti varrógépekkel kapcsolatos
technikai fogalmak rendszerezett definícióját végzik el. Nem titkolt céljuk a
sebészeti eszközök közbeszerzése során észlelhető félreértések elkerülése, a
kettős vagy még többes értelmezések tisztázása, a fogalmak egyértelműsítése.
Summary. Definition and systemic review of the different surgical
staplers are offered in a comprehensive manner. Improved efficacy in tender
decisions, better understanding and usage of clear categories are the main
targets of the present overview.