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Among all scientific traditions alive, medical publishing has a good chance to be the oldest. The first fully peer reviewed academic journal, “Medical Essays and Observations” was launched in 1731 by the Royal Society in Edinburgh. Since then, hundreds of medical journals have been published worldwide. Medical publication in Hungary started in 1857 when the famous physician, Markusovszky founded “Orvosi Hetilap”, which has been published since then every week (with short breaks during the world wars). It is now a most prestigious piece in AKJournals’ portfolio, listed in Journal Citation Reports, with a remarkable impact factor.

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Journal of Behavioral Addictions
Authors:
Shuai Guo
,
Agata Kamionka
,
Qinbo Xue
,
Bernadetta Izydorczyk
,
Małgorzata Lipowska
, and
Mariusz Lipowski

Abstract

Background and aims

Exercise addiction in adults is increasingly recognized as a public health concern, carrying potentially harmful physical, psychological, and social consequences. Body image—encompassing cognitive, behavioral, affective, and perceptual elements—may be a key factor in this risk, yet comprehensive evidence remains scarce. This systematic review and meta-analysis aimed to (1) evaluate the overall relationship between multidimensional body image and the risk of exercise addiction in adults, and (2) identify key moderators (e.g., different elements of body image, gender, region).

Methods

A systematic search was conducted in PsycINFO, Medline, SPORT Discus, Web of Science, and Embase up to October 22, 2024. A three-level meta-analysis model was employed, and univariate and multivariate meta-regressions were used to explore potential moderating factors.

Results

A total of 38 eligible studies were identified, contributing 65 effect sizes. The meta-analysis revealed a moderate correlation (r = 0.26) between body image and risk of exercise addiction in adults. Moreover, the cognitive component of body image and the use of compulsive exercise measures in addiction assessments emerged as unique moderators, each further strengthening the observed relationship.

Discussion and conclusions

These findings underscore the central role of body image—particularly its cognitive dimension—in shaping the risk of exercise addiction in adults, especially when assessed via compulsive exercise measures. Incorporating these insights into research and practice may guide more effective interventions and improve public health strategies aimed at mitigating harmful exercise behaviors.

Open access

Abstract

Background and aims

Smartphones have been so widely adopted that many consider them essential for modern life. However, some people use their phone excessively, which can cause functional impairment or harm, termed problematic smartphone use (PSU). Smartphone use motives may help explain why users engage in general smartphone use and PSU, but existing measures may not capture certain motives which research suggests are important to smartphone use. To address this, across two studies, we constructed and validated a Motives for Smartphone Use Questionnaire (MSUQ) among young adults.

Methods and results

In Study 1, the Delphi method was used, whereby engagement with a panel of 23 international academic experts resulted in a pool of 62 smartphone use motives items that measure 11 proposed motives. In Study 2, the 62 items were administered to 680 young adults aged 18–25 years (M age = 22.50, SD = 2.16). Results from exploratory and confirmatory factor analyses found that the MSUQ has a seven-factor structure, assessing smartphone use to cope, pass time, socialize, obtain social comfort, feel safe, fulfil social obligations, and seek information. These motives differentially influenced PSU and smartphone usage.

Conclusions

The MSUQ is a valid measure of motives for smartphone use. It was developed specifically for smartphone use and it includes motives not captured in prior measures.

Open access

Abstract

Objective

Hallucinogen Persistent Perception Disorder (HPPD) is a condition where the effects of hallucinogenic drugs reoccur long after the acute effects have stopped. No established risk factors or mechanisms for HPPD have been identified. However, reports have suggested a risk phenotype for HPPD due to associations with other perceptual disturbances. With recent increases in therapeutic psychedelic drug use, it is essential to consider the existence of HPPD risk factors. Therefore, exploring potential links between HPPD and other perceptual disturbances, such as tinnitus and migraine with aura, is a necessary first step. This study aimed to investigate the association between HPPD and other perceptual disorders.

Methods

One hundred thirty-eight individuals with HPPD and 116 controls participated in a survey assessing the prevalence of various perceptual disturbances: photosensitivity, phonosensitivity, tinnitus, migraine with aura, vertigo, paraesthesia, and synaesthesia.

Results

The survey results showed a significant association between HPPD and photosensitivity (OR = 10.65), phonosensitivity (OR = 8.00), and the number of perceptual disturbances (OR = 1.59) in the HPPD group compared to the control group. The study also observed trends of dual prevalence between HPPD and tinnitus, migraine with aura, vertigo, paraesthesia, and synaesthesia. Participants with both HPPD and other perceptual disturbances were likelier to experience additional perceptual disturbances after the onset of HPPD.

Conclusions

These findings suggest a common vulnerability or pathophysiological mechanism among these perceptual disturbances. Given the increasing therapeutic use of hallucinogens, the results of this study provide essential considerations for HPPD risk profiles. Moreover, they may guide future investigations into HPPD's pathophysiology and management options.

Open access

Abstract

[68Ga]Ga-PSMA-11 PET/CT (Gallium prostate-specific membrane antigen positron emission tomography/computed tomography) is an established molecular imaging technique for identifying the spread of prostate cancer in patients with biochemical recurrence (BCR) and for initial staging. Penile metastases from prostate cancer are very rare and can be easily misdiagnosed as noncancerous nodules as part of Peyronie's disease. Most cases of penile metastases occur in patients with disseminated disease and are typically diagnosed at advanced stages. In this case, a 74-year-old patient with prostate cancer underwent a successful prostatectomy, ADT, and radiation therapy to the prostate bed, achieving a PSAnadir of 0.01 ng mL−1. Three and a half years after surgery, biochemical recurrence occurred, and the patient was referred to our clinic for a [68Ga]Ga-PSMA-11 PET/CT scan. PET/CT revealed pathological PSMA expression in a proximal part of the penile root, later confirmed by pathohistological analysis as prostate cancer metastasis. Notably, our patient had a PSA value of only 0.53 ng mL−1, one of the lowest serum PSA values reported in the literature for penile metastasis. This case underscores the critical role of [68Ga]Ga-PSMA-11 PET/CT in differentiating benign conditions like Peyronie's disease from metastatic lesions and in detecting rare and unusual metastatic sites.

Open access

Abstract

Physical activity can provide health benefits if done regularly and of sufficient duration and intensity. The World Health Organization recommends adults do 150–300 min of moderate-intensity activity per week, 75–150 min of vigorous-intensity activity, or an equivalent combination.

Physical inactivity is the fourth leading cause of early death globally, with 31% of the world's population not getting enough physical activity. Aging is defined by rapid decline in physical activity, loss of mobility, and premature morbidity.

Low testosterone levels in men decline from 30 to 40 years of age, and this continues until death. Antiaging strategies, such as caloric restriction, balanced diet, regular exercise, weight management, diabetes control, and smoking cessation can prevent and treat aging-related diseases. Exercise significantly boosts testosterone production, with levels varying based on type, frequency, volume, intensity, and duration. It increases muscle steroidogenesis, total testosterone, and free testosterone in the elderly. Testosterone replacement therapy in elderly men improves physical function, strength, protein synthesis, cholesterol, bone density, sexual desire, erectile function, and overall cognition. However, some studies suggest dehydroepiandrosterone supplementation may provide health improvements without negative effects, potentially reversing arterial aging and reducing the risk of cardiovascular diseases. Senolytic therapeutics focus on cellular senescence, and stem cell transplantation investigates the therapeutic potential of older stem cells.

Restricted access

Abstract

The study was conducted in the microbiology laboratory of the First Affiliated Hospital of Hainan Medical University, Haikou, China, from January 2019 to December 2023. A total of 316 consecutive non-duplicate isolates were collected and identified, that belonged to the Bacteroides fragilis group. Identification of the isolated strains was performed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The minimum inhibitory concentration (MIC) of seven antibiotics was determined by agar dilution method. The presence of cfiA, ermF, and nim genes was determined by polymerase chain reaction (PCR). Correlations between the presence of resistance genes and the MIC values of antibiotics were determined using the Pearson correlation coefficient. In the identification process, 214 isolates (67.7%) were identified as B. fragilis, 52 (16.4%) as Bacteroides thetaiotaomicron, 17 (5.4%) as Bacteroides ovatus, 12 (3.8%) as Bacteroides uniformis, 10 (3.2%) as Phocaeicola vulgatus (=Bacteroides vulgatus), 7 (2.2%) as Bacteroides stercoris, and 4 (1.3%) as Parabacteroides distasonis. The presence of cfiA gene moderately correlated with the MIC of imipenem and meropenem (r = 0.34 and r = 0.42, respectively), while resistance to clindamycin and the presence of ermF gene exhibited a very strong correlation (r = 0.72). In the current study, the most active antimicrobial agents against B. fragilis group bacteria were found to be meropenem, imipenem, metronidazole, and piperacillin/tazobactam; however, resistance to clindamycin renders its empirical use inappropriate.

Restricted access
Imaging
Authors:
Csaba Csobay-Novák
,
Gergely Csikós
,
Ákos Bérczi
,
András Szentiványi
,
Péter Osztrogonácz
,
Artúr Hüttl
, and
Péter Sótonyi

Abstract

Thoracoabdominal aneurysms with extent I and II usually represent a challenge for endovascular aortic repair, given the absent proximal landing zone for a standard thoracic endovascular aortic repair. We report a successful endovascular treatment of such an aneurysm with a staged complex repair incorporating a total of eight branches, without the need of a surgical bypass.

Open access

Abstract

A longstanding challenge in the behavioral addictions field has been determining the point at which gaming involvement becomes clinically significant problematic use. Gaming disorder (GD) and hazardous gaming as recent ICD-11 diagnoses have attracted polarized perspectives due in part to the global popularity of recreational gaming and gaming culture. The broad continuum of gaming can often be perceived differently by different parties, including gamers themselves; what might be seen as regular, harmless, and normative to some, may be considered risky and problematic by others. The ICD-11 guidelines provide some clarity by advising that gaming disorder should not be diagnosed based on persistent gaming alone; that gaming as part of a routine, developing skills, changing mood or relieving boredom, or facilitating social interaction is not sufficient for a diagnosis; and that cultural and peer group norms should be considered in diagnosis. In this paper, we examine gaming normality-disorder boundary issues in the areas of conceptualization, assessment, and interventions. Some examples of the complex personal, social, and cultural considerations that arise in gaming diagnoses are provided. We call for researchers in the addiction and health disciplines to grapple with conceptual controversy and conduct the empirical and clinical research needed to ensure that normal recreational gaming is always clearly distinguished from harm and disorder.

Open access

Fejlett technológiák és innovatív megközelítések a neuromusculoskeletalis rehabilitációban

Advanced technologies and innovative approaches in neuromusculoskeletal rehabilitation

Orvosi Hetilap
Authors:
Krisztina Sándor
and
Gábor Fazekas

In recent years, advanced technology-based devices have become increasingly important in rehabilitation. Modern devices such as virtual and augmented reality, exoskeletons, end-effectors and weight-assisted gait training can be of great benefit in restoring mobility and cognitive function when used as a complement to traditional therapies. The development and implementation of protocols and guidelines are needed to ensure that modern rehabilitation technologies are regulated and based on scientific evidence. Advanced technology-based devices require specially trained therapists who are skilled in their use. Therapists play a crucial role not only in selecting the appropriate device, developing the therapeutic plan and delivering treatments based on the principles of traditional physiotherapy but also in motivating patients, which is important during longer treatment processes. Further research is needed to better understand the effectiveness of the devices and how they are used and to develop new guidelines to support their practical application. Improving the cost-effectiveness of the devices is also important, as this can ensure wider availability of the technology, including their home use. Overall, the widespread availability and adoption of modern technology-based solutions by health professionals could offer new long-term rehabilitation perspectives. Orv Hetil. 2025; 166(5): 175–182.

Open access

A petefészek-krioprezerváció és -autotranszplantáció mint a termékenység megőrzésének új lehetősége

Ovarian cryopreservation and autotransplantation as a new method for fertility preservation

Orvosi Hetilap
Authors:
Pál Botond Sík
,
Péter Fancsovits
,
János Urbancsek
,
László Piros
,
Annamária Nemes
,
Kata Joó
,
Nándor Ács
, and
Attila Bokor

Ovarian cryopreservation and autotransplantation offer a promising opportunity for preserving fertility in patients undergoing gonadotoxic treatment of malignant diseases. The aim of the procedure is to restore ovarian function following treatment and prevent premature ovarian failure. The aim of this case study is to present the method of ovarian cryopreservation and autotransplantation and to review the current scientific literature on the subject. A 25-year-old female patient diagnosed with acute lymphoblastic leukemia underwent ovarian tissue cryopreservation prior to myeloablative treatment. Following her remission, the ovarian tissue was orthotopically autotransplanted, after which the patient was monitored through weekly hormone level assessments (FSH, LH, estradiol, progesterone) and transvaginal ultrasounds. Gonadotropin and ovarian hormone levels showed no significant changes between postoperative days 7 and 63. By day 145, ovarian endocrine function was restored as indicated by decreased gonadotropin levels and normalized estradiol levels. In the literature, the 5-year survival rate of ovarian grafts during long-term follow-up was reported at 55%, with restoration of reproductive function and spontaneous pregnancies occurring in some cases. The method has proven effective in restoring both endocrine and reproductive functions, with the highest likelihood of achieving pregnancy shortly after the procedure. Previous studies have reported live birth rates as high as 41% following ovarian cryopreservation and autotransplantation. Ovarian cryopreservation and autotransplantation provide a valuable opportunity for preserving fertility in patients undergoing gonadotoxic treatments. Although our experience is limited to a single case, the results are encouraging. Further research is needed to optimize the procedure and expand its clinical application. Orv Hetil. 2025; 166(5): 195–200.

Open access