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Among all scientific traditions alive, medical publishing has a good chance to be the oldest. The first fully peer reviewed academic journal, “Medical Essays and Observations” was launched in 1731 by the Royal Society in Edinburgh. Since then, hundreds of medical journals have been published worldwide. Medical publication in Hungary started in 1857 when the famous physician, Markusovszky founded “Orvosi Hetilap”, which has been published since then every week (with short breaks during the world wars). It is now a most prestigious piece in AKJournals’ portfolio, listed in Journal Citation Reports, with a remarkable impact factor.

Medical and Health Sciences

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Acta Veterinaria Hungarica
Authors:
Piotr Cybulski
,
Katrin Strutzberg-Minder
,
Edyta Michalik
,
Radosław Kondratiuk
, and
Artur Jabłoński

Abstract

Nowadays, the three strongly beta-haemolytic spirochaetes, Brachyspira hyodysenteriae, Brachyspira suanatina and Brachyspira hampsonii are thought to be causative agents of swine dysentery, an economically devastating disease of grow-finish pigs characterised by severe mucohaemorrhagic diarrhoea. B. hyodysenteriae has been reported in most leading swine-producing regions. B. suanatina and B. hampsonii have been successfully recovered from faecal samples collected in a few countries only. The present study was performed in March 2023 on faecal samples originating from nine Polish finisher farms with 6,000 to 18,000 animals in a location. Samples were obtained from 40 diarrhoeic finishers. Nucleic acid extracted from the samples was analysed using multiplex PCR for Brachyspira spp. From a total of nine sample populations examined in our study, the genetic material of B. hampsonii was identified in two. To the best of our knowledge, this is the first report on molecular detection of B. hampsonii on pig farms outside North America, Belgium and Germany. Our research highlights the need for increased focus directed on laboratory testing strategies, the lack of which may perplex swine practitioners and severely hinder a definite diagnosis.

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Abstract

This study investigated the sero-epidemiology of bluetongue in ruminants in North-Western Pakistan. A total of 3,173 serum samples were collected from small (n = 1,651) and large (n = 1,522) ruminants being reared by farmers in 14 districts. Antibodies to bluetongue virus (BTV) were detected using competitive ELISA. The overall prevalence of BTV antibodies was 65%. A significant association (P < 0.05) between the prevalence of BTV antibodies and the risk factors including sex, species, age, area, husbandry practices and breed was shown by univariate analysis. In multivariate analysis, the seroprevalence was 6.5 (95% CL = 3.7–11.4), 5.9 (95% CL = 3.8–9.4) and 2.4 (95% CL = 1.5–3.7) times higher in buffaloes, cattle and goats than sheep, respectively. The seroprevalence was 1.4 (95% CL = 1.1–1.7) times higher in local breeds than in cross/exotic breeds. The seroprevalence was 1.6 (95% CL = 1.1 to 2.3) times higher in sedentary animals than in nomadic animals. The seroprevalence was significantly associated with age. Further work is required to determine the BTV serotypes prevalent in the study area for effective control of the disease.

Restricted access
Acta Veterinaria Hungarica
Authors:
Dominik Gulyás
,
Gábor Kovács
,
István Jankovics
,
Máté Hidvégi
,
Béla Dénes
,
Lilla Kálfalvy-Molnár
,
Rebeka Nagypál
, and
Márta Lőrincz

Abstract

The interplay of regulatory T cells (Tregs) within the tumour microenvironment presents a significant challenge in anticancer immunotherapy. This study investigates the potential of Treg blockade to enhance the efficiency of effector T cells. Two distinct treatment cocktails were examined: 3p-hpRNA (5′ triphosphate hairpin RNA) combined with unmethylated CpG oligonucleotide (CpG); CpG in combination with OX40 receptor-specific monoclonal antibody (anti-OX40). Treatment efficacy was assessed using a murine model of kidney adenocarcinoma.

Renca cells (renal cortical cells with adenocarcinoma) were subcutaneously engrafted in 30 BALB/c mice, then animals were allocated into three treatment groups: Group 1: CpG+anti-OX40, Group 2: CpG+3p-hpRNA, Group 3: untreated control. Treatment efficacy was evaluated based on tumour growth, the occurrence of metastases and overall survival.

On day 28 post-implantation, experiments had to be terminated due to tumour progression. Although comparisons of survival times and primary tumour sizes thus became inconsequential, histological examinations provided valuable insights. We observed distinct variations in primary tumour characteristics among the different groups: Groups 1 and 2 displayed demarcations, while Group 3 exhibited diffuse tumours with necrosis. Lung metastases were evident in 70% of untreated mice, whereas none were observed in either of the treated groups.

Our findings instil confidence in the potential efficacy of the treatments, thereby laying a solid foundation for future investigations.

Open access

Abstract

Dissection of the matter into its constituents leads us to the smallest particles that we know. These particles form a material structure that is determined by the electromagnetic field generated and carried by those particles. Changes in any of the two major constituents leads to changes in that material system, be it a living organism or a lifeless object. The latter statement carries the mystery of life that is born from a continuous and programmed series of system changes fuelled by an energy source with a yet unknown functioning mechanism. The present work is a theoretical approach towards the understanding and potential discovery of the aforementioned, not-yet-known cellular energetic mechanism. Understanding the energetic basis of intracellular biochemistry is equally important in human and animal therapeutics. Additionally, as all such discoveries offer novel solutions in various fields of the global industry, the final outcome of this theoretical work also brings about the idea of a new discovery in electronics industry.

Open access

Abstract

Background and aims

The association between perceived stress (PS) and gaming addiction (GA) is well documented. However, the mechanism for explaining this association remains unclear. Using a genetically informative design, this study aims to distinguish between the diathesis-stress and bio-ecological models of gene by environment interaction (G x E) to explain the underlying mechanism of the relationship.

Methods

In total, 1,468 twins (mean age = 22.6 ± 2.8 years) completed an online survey including the GA and PS scales. Twin correlations for GA and PS were computed and univariate model-fitting analysis was conducted to determine genetic and environmental influences on GA and PS. The bivariate G x E model-fitting analysis was performed to determine the best G x E interaction model.

Results

Additive genetic, shared environmental, and non-shared environmental effects were 0.70 (95%CI = 0.61, 0.77), 0.00, and 0.30 (95%CI = 0.26, 0.33), and 0.38 (95%CI = 0.24, 0.55), 0.35 (95% CI = 0.18, 0.51), and 0.22 (95%CI = 0.20, 0.26) for GA and PS, respectively. Bivariate G x E model-fitting analysis supported the diathesis-stress model, where genetic influences on GA were greater in higher levels of PS, whereas environmental influences on GA were small and constant across levels of PS.

Discussion and conclusions

The evidence for the diathesis-stress model for GA is consistent with the etiological process of many forms of psychopathology. The findings should be incorporated in clinical settings to improve the treatment of GA, and used in developments of intervention and prevention methods for GA.

Open access

Abstract

Purpose

The COVID-19 pandemic has had an enormous negative impact on the psychosomatic status of the general population, and especially of more vulnerable populations, such as older people. The present study aimed to assess changes in psychosomatic status before and after the COVID-19 pandemic among emeritus professors over 70 years of age.

Materials/Methods

A total of 56 emeritus professors aged 77.4 ± 6.1 (74.1% male) participated in the study. The study was conducted between September 2022 and January 2023, after approximately two and a half years of the COVID-19 pandemic. Sociodemographic characteristics, including socioeconomic status, were assessed in the questionnaire, along with active involvement in academic life and healthcare/sports. Physical and mental fatigue were assessed using a self-report questionnaire, and the impact of fatigue on physical and cognitive function was measured using the Fatigue Impact Scale. Participants evaluated their physical/mental fatigue and physical/cognitive function before and after the COVID-19 pandemic.

Results

Among the participating emeritus professors, 15% reported higher levels of physical fatigue (Z = −1.992, P = 0.046, r = 0.28) and mental fatigue (Z = −2.154, P = 0.031, r = 0.31) following the COVID-19 pandemic. A significant difference was found in physical function assessed before and after the COVID-19 pandemic, t(51) = −2.986, P = 0.004, g = 0.22, while cognitive function showed a non-significant difference, t(51) = −1.265, P = 0.212, g = 0.12. After the COVID-19 pandemic, 26.9% of participants reported reduced physical function and 19.2% showed reduced cognitive function. Infection with the COVID-19 virus resulted in increased mental fatigue and reduced cognitive function among the participating emeritus professors.

Conclusion

The COVID-19 pandemic (and the introduction of restrictions on social activities) had a substantial and similar impact on the psychosomatic status of emeritus professors at both medical and sports universities. Furthermore, the reduction in physical and mental/cognitive function was exacerbated in those who were infected by SARS-CoV-2. Importantly, however, the overall impact of the COVID-19 pandemic was smaller in the population of emeritus professors than in the general elderly population. This may be due to the better maintenance of physical and mental activity in the former population, thus emphasising the importance of remaining physically and mentally active in old age, especially in the context of critical life events.

Open access

Cisztás Fibrózis Regiszter és Tuberkulózis Surveillance Rendszer az Országos Korányi Pulmonológiai Intézetben

Cystic Fibrosis Registry and Tuberculosis Surveillance System in the National Korányi Institute for Pulmonology

Orvosi Hetilap
Authors:
Zsuzsa Cselkó
,
Adrien Halász
,
István Gaudi
,
István Zsarnóczay
, and
Krisztina Bogos

A betegségregiszter olyan, népességre vonatkozó nyilvántartási rendszer, amelynek célja, hogy demográfiai és klinikai információk gyűjtésével, elemzésével, hasznosításával segítse az egészségügyi ellátás minőségének javítását. A magyarországi betegségregiszterek létrehozását és működtetését a 49/2018. számú EMMI rendelet szabályozza. Az Országos Korányi Pulmonológiai Intézet eddig alkalmazott, saját fejlesztésű online adatgyűjtő rendszerei – főként a 2010 óta működő Tuberkulózis Surveillance Rendszer – számottevő tapasztalatot eredményeztek a betegségregiszterek kifejlesztése és üzemeltetése terén. E tapasztalatra építve jött létre 2022-ben a Nemzeti Cisztás Fibrózis Regiszter. A közlemény célja, hogy bemutassa az Országos Korányi Pulmonológiai Intézetben működő Nemzeti Cisztás Fibrózis Regiszter és Tuberkulózis Surveillance Rendszer funkcióját és eredményeit. Orv Hetil. 2024; 165(24–25): 965–972.

Open access

Előszó a regiszterekkel foglalkozó tematikus számhoz

Preface to the thematic issue on disease registries

Orvosi Hetilap
Author:
András Jánosi
Open access

A humán reprodukcióval kapcsolatos hazai regiszterek

National registries related to human reproduction

Orvosi Hetilap
Authors:
Dóra Vesztergom
,
Miklós Szabó
,
István Sziller
,
Andrea Valek
,
Zsuzsanna Turi
,
Ákos Szekrényes
,
Katalin Szöllősi
,
Anna Krádi
,
Zsuzsanna Kéki
,
Emese Vita
, and
Béla Muzsik

A női egészség, a reprodukció és a megszületett gyermekek egészsége az egészségügyi ellátórendszer első számú prioritásai közé tartozik. A meddőségkezelés, a nagy rizikójú újszülöttek intenzív ellátása a jövő generációk egészségének meghatározó tényezői, mindemellett eredményességük demográfiai jelentőséggel bír. Az ellátórendszer hatékony működésének feltétele a korszerű, átlátható adatgyűjtés és -feldolgozás, valamint szakmai értékelő és elemző munka. Az informatika fejlődésével lehetővé vált az eddiginél pontosabb, strukturáltabb adatok gyűjtése és a különböző regiszterekből származó adatok egy adatbázisban történő összekapcsolása. A Nemzeti In Vitro Fertilizációs, Szülészeti és Perinatális Regiszter a Humán Reprodukciós Regiszter, a Tauffer–Csákány Statisztika és a Peri- és Neonatális Regiszter összekapcsolásával olyan szakmai egységet alkot a jövőben, amely alkalmas arra, hogy hazai viszonylatokban mérve az egyik legrészletesebb adatkezelés és -kiértékelés alapjául szolgáljon, amely a legcélravezetőbb mód a rendszer hatékonyságának növelésére, és alapját képezi az ellátórendszer folyamatos fejlesztésének. Orv Hetil. 2024; 165(24–25): 973–980.

Open access

Nemzeti Gyermekonkológiai Regiszter

National Childhood Cancer Registry

Orvosi Hetilap
Authors:
Miklós Garami
and
Zsuzsanna Jakab

A Magyar Gyermekonkológiai Hálózat 1971 óta működteti a gyermekkori daganatos betegségek epidemiológiájára, a gyógykezelés módjára és eredményességére, illetve a betegek további sorsára, késői utánkövetésére vonatkozó adatokat összegző Gyermekonkológiai Regisztert. A Regiszter székhelye a Semmelweis Egyetem Gyermekgyógyászati Klinikájának Tűzoltó utcai részlege. Jelentős változás történt az adatgyűjtés/bejelentés módjában, kiépült és 2010 áprilisától véglegesen átvette az internetes bejelentési rendszer a korábbi papíralapú bejelentési formát. Az adatok forrása többek között a Nemzeti Egészségbiztosítási Alapkezelő, illetve a Magyar Gyermekonkológiai Hálózat kezelőközpontjai. A Nemzeti Gyermekonkológiai Regiszter valamennyi 0–18 év közötti magyar, társadalombiztosítási kártyával rendelkező beteg gyermek adatait tartalmazza. A Regiszter online adatbevitelre épül, az adatok ellenőrzése és a Regiszter teljességének követése szigorú írott eljárások mentén történik. Az adatok publikálása több módon, többek között éves riportok, tudományos közlemények és előadások formájában történik. A Gyermekonkológiai Regiszter 1971. évi létrehozása és folyamatos üzemeltetése az egyik legfontosabb lépés volt a gyermekonkológia területén, mind a kezelési eljárások kiértékelésének, mind az egészségügyi befektetés megtérülésének maximalizálása érdekében. Orv Hetil. 2024; 165(24–25): 933–943.

Open access