Among all scientific traditions alive, medical publishing has a good chance to be the oldest. The first fully peer reviewed academic journal, “Medical Essays and Observations” was launched in 1731 by the Royal Society in Edinburgh. Since then, hundreds of medical journals have been published worldwide. Medical publication in Hungary started in 1857 when the famous physician, Markusovszky founded “Orvosi Hetilap”, which has been published since then every week (with short breaks during the world wars). It is now a most prestigious piece in AKJournals’ portfolio, listed in Journal Citation Reports, with a remarkable impact factor.
Discover the latest journals in Medical and Health Sciences
The primary function of medical articles is the validation of cutting-edge theoretical and clinical research, by providing reference and relevant forums. New drugs and medical practices can only enter the mainstream practise if their randomised trials had passed under the critical lens of prestigious peer reviewed journals. Technical reports help practitioners to improve their arsenal. Case reports confirm theories and provide tools for investigating or disclosing possible malpractice. Review articles serve educational purposes. Some more popular articles may play a role in educating the interested audience.
Types of medical articles
The papers published in medical journals can be classified in the following main categories
Research articles report about novel research results, of both theoretical and (direct or indirect) practical relevance.
Review articles survey specific topics by summarising and analysing all information available in the medical literature. Reviews are kind of combining results from different studies on the same topic. They can be useful for specialists in the field, may help them to prevent, diagnose, or treat a particular disease.
Case reports and case series reports about a concrete story of a concrete patient. They can be interesting because of their uniqueness, not matching any known diagnosis or describing unexpected symptoms. The report should describe each of the diagnosis, treatment, the patient’s response to it and the follow-up history. Case series are related reports about similarly treated patients.
Editorials are typically not peer reviewed shorter communications from senior members of the Editorial Board or from invited renown scholars. They discuss questions of relevance for the scientific community at the moment (say, about public health, or more generally, the health system).
Letters to the editor are articles of the interactive type, a form for readers to contact the medical journal. They can express comments, questions, or criticisms regarding some articles published in that journal. They provide a sophisticated forum for medical communities.
Medical Journals at AKJournals
AKJournals has 9 medical journals. Three of them are in Hungarian. The other six journals are in English and accept submissions from all over the world. Some of them are widely available Open Access journals. The covered topics include immunology, medical imaging, physiology, and veterinary and health care science. In these journals, you can find more than 11.000 medical articles altogether. A filter tool helps to single out the relevant titles. In addition to that, we highly recommend using the search box to find the most important topics only
Authors:B. Kovács, I. Kóbor, Ö. Sebestyén, and J. Tihanyi
Based on the current literature, the link between Achilles tendon moment arm length and running economy is not well understood. Therefore, the aim of this study was to further investigate the connection between Achilles tendon moment arm and running economy and the influence of Achilles tendon moment arm on the function of the plantarflexor muscle-tendon unit during running.
Ten male competitive marathon runners volunteered for this study. The participants ran on a treadmill at two running speeds: 3 and 3.5 m s−1. During running the oxygen consumption, lower leg kinematics, electrical activity of plantar flexor muscles, and fascicle behavior of the lateral gastrocnemius were measured simultaneously. On the second occasion, an MRI scan of the right leg was taken and used to estimate the Achilles tendon moment arm length.
There was a negative correlation between running economy and the body height normalized moment arm length at both selected speeds (r = −0.68, P = 0.014 and r = −0.70, P = 0.01). In addition, Achilles tendon moment arm length correlated with the amplitude of the ankle flexion at both speeds (r = −0.59, P = 0.03 and r = −0.60, P = 0.03) and with the electrical activity of the medial gastrocnemius muscle at 3 m s−1 speed (r = −0.62, P = 0.02). Our finding supports the concept that a longer moment arm could be beneficial for distance runners.
Authors:H. Xie, L. Cao, L. Ye, G. Shan, and W. Song
In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3‐E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase signalling was performed in miR-1906 mimic-treated, receptor-activated nuclear factor kappa-B (NF-κB) ligand (RANKL)-induced osteoclasts. In-vivo, osteoporosis was induced by ovariectomy (OVX). Rats were treated with 500 nmol/kg of the miR-1906 mimic via intrathecal administration for 10 consecutive days following surgery. The effect of the miR-1906 mimic on bone mineral density (BMD) in OVX rats was observed in the whole body, lumbar vertebrae and femur. Levels of biochemical parameters and cytokines in the serum of miR-1906 mimic-treated OVX rats were analysed. The mRNA expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), p-38 and NF-κB in tibias of osteoporotic rats (induced by ovariectomy) was observed using quantitative reverse-transcription polymerase chain reaction. Treatment with the miR-1906 mimic reduced cellular toxicity and enhanced the cell viability of MC3T3‐E1 cells. Furthermore, osteoclastogenesis in miR-1906 mimic-treated, RANKL-induced osteoclast cells was reduced, whereas the BMD in the miR-1906 mimic-treated group was higher than in the OVX group of rats. Treatment with the miR-1906 mimic also increased levels of biochemical parameters and cytokines in the serum of ovariectomised rats. Finally, mRNA expression levels of TLR4, MyD88, p-38 and NF-κB were lower in the tibias of miR-1906 mimic-treated rats than in those of OVX rats. In conclusion, the miR-1906 mimic reduces bone loss in rats with ovariectomy-induced osteoporosis by regulating the TLR4/MyD88/NF‐κB pathway.
Authors:Takashi Abe, Vickie Wong, Zachary W. Bell, Robert W. Spitz, Scott J. Dankel, and Jeremy P. Loenneke
It has been observed that gluteal-femoral adipose tissue has a protective effect against risk factors for cardiovascular disease but has not yet been concluded how different evaluation methods of fat distribution affect the results.
To test the hypothesis that B-mode ultrasound-measured subcutaneous adipose tissue distribution is associated with cardiovascular risk factors, 326 Japanese unmedicated postmenopausal women aged 50-70 years were analyzed. Subcutaneous adipose tissue thickness at 6 sites (anterior and posterior aspects of trunk, upper-arm, and thigh) and serum total (TC) and high-density lipoprotein cholesterol (HDLC) was measured, and a ratio of HDLC to TC (HDLC/TC) was calculated. We used Bayesian linear regression with 4 separate models with each model predicting HDLC/TC.
Our first model provided evidence for an inverse correlation (r = –0.23) between ultrasound measured body fat (6 site measurement) and HDLC/TC. The second model noted evidence for an inverse correlation between trunk fat and HDLC/TC and found evidence for the null with respect to the correlation between thigh fat and HDLC/TC. Therefore, we added thigh fat to the null model to produce Distribution Model 2. Within this model, we noted an inverse correlation (r = –0.353) between trunk fat and HDLC/TC. Our last model determined that within the trunk fatness, the abdominal area (anterior trunk) was a larger predictor than the subscapular site (posterior trunk).
These results support the evidence that ultrasound-measured abdominal subcutaneous adipose tissue thickness is a non-invasive predictor for monitoring the risk for dyslipidemia in postmenopausal women.
The present case report describes the clinical signs and case resolution of an intact 9-year-old male crossbreed dog with spontaneous constipation. The dog presented with abdominal pain, lack of appetite, tenesmus and without signs of defecation in the last 4 days. No important alterations were observed in the complete blood count and biochemistry. A substantial obstruction caused by a faecaloma and a prostate with increased size was observed on X-rays. Benign prostatic hyperplasia (BPH) was confirmed by ultrasonography (size: 48.29 cm3) and by testing the serum canine prostate-specific arginine esterase concentration (105.97 ng/mL). Colon impaction was resolved with rectal enemas within two days. BPH was treated with osaterone acetate. Ultrasonographic checks were performed after 60 and 180 days from the demission and a concrete constant reduction of prostatic volume and of the clinical signs was established. Faecaloma is an uncommon finding in male dogs, and it occurs especially as a consequence of BPH. Colon impaction in patients with BPH is usually subclinical, but it is important to underline how, in severe cases, perforation of the colon and faecal peritonitis can occur, leading to fatal conditions for the animal. In conclusion, prostatic enlargement should always be considered in male dogs suffering from colonic impaction.
Authors:Zoltán Szekanecz, Krisztina Bogos, Tamás Constantin, Béla Fülesdi, Veronika Müller, Éva Rákóczi, István Várkonyi, and István Vályi-Nagy
Összefoglaló. Az új típusú koronavírus-fertőzés (COVID–19) nagy
terhet ró az egészségügyi ellátórendszerre és a társadalomra. A betegségnek
három nagy szakasza van, melyek alapvetően meghatározzák a kezelést. Az I–IIA
fázisban az antivirális, míg a IIB–III. fázisban a gyulladásgátló kezelés áll
előtérben, melyhez intenzív terápiás, szupportív kezelés csatlakozik. A jelen
ajánlás kizárólag a gyógyszeres kezelésre vonatkozik, és a rendelkezésre álló
bizonyítékok alapján foglalja össze a terápiás lehetőségeket. Emellett egy
javasolt kezelési algoritmust is tartalmaz. Orv Hetil. 2021; 162(17):
Summary. The novel coronavirus infection (COVID-19) places a heavy
burden on the health care system and our society. There are three major stages
in the disease that fundamentally determine treatment approaches. Phases I–IIA
require primarily antiviral treatment. In phases IIB–III, anti-inflammatory
treatment is needed accompanied by intensive and supportive care. This
recommendation applies only to pharmacotherapy and summarizes the therapeutic
options based on the available evidence. It also includes a proposed treatment
algorithm. Orv Hetil. 2021; 162(17): 643–651.
Authors:Zsuzsanna Gurdán, József Szalma, and Pálma Benedek
Összefoglaló. Az achondroplasia kialakulásáért az
FGFR3-gén mutációja tehető felelőssé, mely a porc
növekedési lemezében található chondrocyták érésében okoz zavart. Az
esetbemutatásban szereplő lánygyermeknél a születést követő első hónapban a
klinikai, laboratóriumi és röntgenvizsgálatok alapján achondroplasia
igazolódott. A klinikai tünetek közé tartoznak a rövid végtagok – különösen a
proximalis szegmensben –, a macrocephalia, a hypotonia és a horkolás. Szembetűnő
a középarc hypoplasiája. A középfül diszfunkciója tovább súlyosbítja a kórképet,
sok esetben megfigyelhető a hallás nagyfokú csökkenése, illetve kezelés
hiányában akár a hallás elvesztése. A közlemény részletesen bemutatja az
obstruktív alvási apnoe szindróma diagnózisrendszerét és kezelési alternatíváit,
hangsúlyozva az orthodontiai szempontokat. A fül-orr-gégészeti és a
fogszabályozó terápiának köszönhetően, a diagnózistól számított harmadik évre,
az alvási apnoe szindróma megszüntetésével a folyamatos pozitív nyomású
lélegeztetést el lehetett hagyni. A horkolás és az alvási apnoe szindróma
kezelése napjainkban egyre nagyobb hangsúlyt kap, melynek komplex kezelésében a
fogszabályozás is jelentős lehet. A harmonikus együttműködés és teamkezelés
betegünknél jelentős életminőség-javulást eredményezett. Orv Hetil. 2021;
Summary. Development of achondroplasia is due to the mutation of
FGFR3 gene, which disrupts the maturation of chondrocytes
found in the growth plate. The diagnosis of the girl in the present case study
was established based on clinical symptoms, laboratory tests and X-ray imaging
in the first month following childbirth. Clinical symptoms include shorter limbs
especially in the proximal segments, macrocephaly, hypotonia and snoring.
Hypoplasia of the midface is apparent. Dysfunction of the middle ear further
worsens the condition, in many cases severe hearing loss and, without treatment,
even deafness can be observed. The publication describes the diagnostic criteria
and therapeutic options of obstructive sleep apnea syndrome in detail, with an
emphasis on the orthodontic aspects. A comprehensive combined three-year
oto-laryngological and orthodontic treatment finally succeeded in controlling
the sleep apnea syndrome and it was possible to discontinue the continuous
positive airway pressure therapy by the end of the orthodontic therapy.
Nowadays, even more alternative therapeutic approaches are available to treat
snoring and sleep apnea syndromes, in which the role of orthodontics must not be
neglected. Harmonic collaboration and team work treatment resulted in a
significant improvement in the quality of life of our patient. Orv Hetil. 2021;
Authors:Sae-Young Won, Yong-Chan Kim, and Byung-Hoon Jeong
Prion disease is a fatal neurodegenerative disease with a broad host range in humans and animals. It is caused by proteinase K-resistant prion protein (PrPres). In previous studies, a heterogeneous infection in Cervidae and Caprinae was reported. Chronic wasting disease (CWD) has been frequently reported as the only prion disease in Korea that occurs in livestock. Thus, there is a possibility of transmission of CWD to Korean native black goats. However, PrPres has not been investigated thus far in Korean native black goats. We found strong linkage disequilibrium between c.126G>A and c.414T>C (r2 = 1) and between c.718C>T and c.126G>A (r2 = 0.638). In addition, the haplotype GTGTAAAC (representing codons 42, 102, 127, 138, 143, 146, 218 and 240) showed the highest frequency with 45.1%. Among 41 Korean native black goats, 20 animals (48.78%) were homozygous for the susceptible haplotypes (histidine at codon 143, asparagine at codon 146 and arginine at codon 154). Interestingly, we did not detect PrPres bands in any of the tested animals, including the 20 animals carrying potential scrapie susceptible haplotypes.
Authors:Tamás Constantin, Noémi Andrási, Andrea Ponyi, Ádám Goschler, László Ablonczy, Judit Kincs, Monika Csóka, Bálint Egyed, Zsuzsanna Horváth, Krisztina Kalocsai, Rita Káposzta, Kinga Kardics, Viktória Kemény, Bernadett Mosdósi, Tamás Pék, Zsófia Szabó, Attila Tóth, Kálmán Tory, Andrea Tölgyesi, Beáta Ónozó, Hajnalka Vágó, Csaba Vilmányi, Weiser Peter, Zoltán Szekanecz, Gábor Kovács, and Attila Szabó
Összefoglaló. A SARS-CoV-2-fertőzés ritka gyermekkori szövődménye a
sokszervi gyulladás, angol terminológiával paediatric inflammatory multisystem
syndrome (PIMS). Két vagy több szerv érintettségével járó, súlyos tünetekkel
induló betegségről van szó, amelynek tünetei átfedést mutatnak a
Kawasaki-betegséggel, a toxikus sokk szindrómával és a makrofágaktivációs
szindrómával. A PIMS-betegek intenzív terápiás osztályon vagy intenzív terápiás
háttérrel rendelkező intézményben kezelendők, ahol biztosítottak a kardiológiai
ellátás feltételei is. A szükséges immunterápia a klinikai prezentációtól függ.
A jelen közleményben a szerzők a releváns nemzetközi irodalom áttekintését
követően ajánlást tesznek a PIMS diagnosztikai és terápiás algoritmusára. Orv
Hetil. 2021; 162(17): 652–667.
Summary. Pediatric inflammatory multisystem syndrome (PIMS) is a
rare complication of SARS-CoV-2 infection in children. PIMS is a severe
condition, involving two or more organ systems. The symptoms overlap with
Kawasaki disease, toxic shock syndrome and macrophage activation syndrome. PIMS
patients should be treated in an intensive care unit or in an institution with
an intensive care background, where cardiological care is also provided. The
required specific immunotherapy depends on the clinical presentation. In this
paper, after reviewing the relevant international literature, the authors make a
recommendation for the diagnostic and therapeutic algorithm for PIMS. Orv Hetil.
2021; 162(17): 652–667.
Authors:Máté Magyar, Tibor Glasz, Tekla Kovács, András Bálint Deák, Pál Maurovich-Horvat, and Balázs Futácsi
Gastroparesis, a form of gastrointestinal dysfunction and the increased risk for aspiration pneumonia are well known complications in patients with Parkinson’s disease. In our case report we demonstrate the case of an 83-year-old, bedridden male patient with Parkinson’s disease, who had a slowly progressing stomach dilation, gradually pushing the otherwise normal liver to a highly unusual craniodorsally rotated position.