Authors:A. Bumbálová, E. Havránek, M. Harangozó, P. Křenek, and S. Lübkeová
The preparation of N1-(octadecylcarbomyl-methy)-ethylenediaminetriacetic acid labelled with99mTc is described. Reduction of technetium was made using sodium borohydride (procedure A) or stannous chloride (procedure B), and the labelling efficiency was checked by thin layer chromatography. Preliminary studies of biol-behavior of this complex were performed in white rats.
Authors:E. Havránek, A. Bumbálová, V. Kettmann, J. Světlík, and J. Sivý
The preparation of99mTc-complexes with nine derivatives of (4R)-1,3-thiazolidine-4-carboxylic acid over a broad pH range is described. The labeling efficiency of all compounds was checked by paper- and thin layer chromatography. Paper electrophoresis and gel chromatography indicated the presence of two types of99mTc-complexes differing in charge and molecular size. Preliminary results of the biodistribution of anionic complexes in mice are given. The structure of both types of the Tc-complexes is also discussed.
Authors:O. Štroffeková, V. Jánošová, M. Sýkorová, and E. Havránek
This paper aimed to the evaluation of different kinds of sorbent material preparation and to the evaluation of their characteristics
at different pH conditions by X-ray fluorescence analysis. This method is suitable for identification and determination of
elements in samples of different character, state and origin because it is a polycomponent, non-destructive, fast and simple
analytical method. Moreover, it allows time-advantageous and reliable measurements. This paper studies problems concerning
the determination of some selected elements (Mn, Fe, Ni, Cu, Zn, Pb) in pharmaceutical samples of sodium chloride in the solid
state as well as in its solution by sorption on chelating extraction membrane 3M Empore™ and on the strongly acidic ion-exchanger
Dowex 50Wx8. Conditions for the most effective sorption of determined elements are also interpreted.
Authors:E. Havránek, A. Bumbálová, M. Komová, M. Beláková, P. Butvin, and V. Kettmann
A series of bidentate and tetradentate ligands with azomethine and Ar–OH functional groups derived from salicylaldehyde and primary alkyl or aryl monoamines and diamines has been synthesized and labeled with99mTc at various pH's using stannous chloride as reducing agent. The labeling efficiency was monitored by thin layer and paper chromatography.
Authors:E. Havránek, A. Bumbálová, P. Křenek, M. Strašák, M. Beláková, and M. Komová
The preparation of99mTc-Sn-EBV and99mTC-Sn-EBA is described. Different parameters affecting the labeling efficiency (ligand concentration, pH, molar ligand: reducing agent ratio) as well as the time-dependent stability of labeled compounds were investigated. Preliminary biodistribution studies in Wistar rats showed accumulation of the above mentioned compounds in kidneys.