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  • Author or Editor: B Howell x
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Abstract  

A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.

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Abstract  

The thermal degradation characteristics of head-to-head poly(styrene) [HHPS] should provide insight with respect to the impact of head-to-head placement on the thermal stability of traditional atactic head-to-tail polymer [HTPS]. The synthesis of head-to-head poly(styrene) must be accomplished indirectly. The head-to-head polymer is most satisfactorily obtained by dissolving metal reduction of poly(2,3-diphenyl-1,3-butadiene) [PDBD] generated by radical polymerization of the corresponding diene monomer. Full saturation of the polymer mainchain requires several iterations of the reduction procedure. Since the decomposition of poly(2,3-diphenyl-1,3-butadiene) is prominent at 374C and that for head-to-head poly(styrene) is similarly facile at 406C, it seemed feasible that TG of partially hydrogenated PDBD might be utilized as a convenient means of monitoring the extent of hydrogenation. This has been demonstrated for various levels of unsaturation remaining - from approximately 90 to less than 10%. Within this range the peak areas from the DTG plots of the partially hydrogenated polymer provide a good reflection of the ratio of unsaturated to saturated units in the polymer. Even low levels of unsaturation in the polymer may be detected by the asymmetry of the decomposition peak for the polymer.

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Abstract

A difunctional imide monomer may be produced from 4-nitrophthalic anhydride and m-phenylenediamine. The requisite anhydride may be generated by nitration of phthalimide followed by hydrolysis to the corresponding acid and dehydration. All intermediate compounds have been fully characterized using spectroscopic and thermal methods.

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Abstract

The thermal degradation of a series of 1,1,2,2-tetraaryl-1,2-ethanediols has been examined using thermogravimetry (TG) and gas chromatography/mass spectrometry (GC/MS). These compounds are smoothly converted to the corresponding diaryl ketone and diaryl carbinol, i.e., the compounds undergo disproportionation arising from homolytic cleavage of the central carbon–carbon bond. Presumably, cleavage of the carbon–carbon bond generates a radical pair which disproportionates to provide the observed products.

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Abstract  

Organoplatinum antitumor agents are very effective, broad-spectrum drugs used for the treatment of a variety of cancerous conditions. The two most prominent of these, Cisplatin [cis-diamminodichloroplatinum(II)] and Carboplatin [diammino(1,1-cyclobutanedicarboxylato)platinum(II)], are large scale commercial successes. The third, Oxaliplatin [((trans-1,2-diamminocyclohexane)oxalato)platinum(II)], is now commercially available. The administration of all these drugs is accompanied by severe side effects. For Cisplatin, the most debilitating of these is kidney damage and extreme nausea. Several approaches to generate drug-release formulations that might mitigate toxic side effects have been explored. Now, platinum(IV) compounds which are more inert than platinum(II) compounds, and consequently less toxic, but which may be reduced to platinum(II) species within the cell are being evaluated for effectiveness in the treatment of cancer. The thermal stability of several precursors to compounds of this kind has been examined by thermogravimetry. In general, these materials lose ligands sequentially to generate a residue of platinum. This behavior may be generally useful for the characterization of such materials.

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Abstract  

Two standard vinylidene chloride copolymers, the first containing approximately 9 mass% methyl acrylate and the second containing vinyl chloride at a nominal 15 mass% were prepared by radical suspension techniques using a series of peroxide and azo initiators (all of approximately the same half-life temperature for decomposition). The nature of the initiator could impact the stability of the resulting polymer in two ways. Instability could be introduced either via end-group effects or by attack of residual initiator fragments on the finished polymer during isolation and residual monomer stripping. In this case, the relative thermal stability of the resins produced was assessed by exposing samples to heat and shear in an air environment in a two-roll mill (Brabender Prep-Mill). The rate and extent of degradation was most readily apparent from color development during this treatment. The more thermally stable polymers were produced using initiator radicals that did not attack the polymer during isolation/stripping processes.

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