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Journal of Radioanalytical and Nuclear Chemistry
Authors:
J. Németh
,
B. Jakab
,
R. Józsa
,
T. Hollósy
,
A. Tamás
,
A. Lubics
,
I. Lengvári
,
P. Kiss
,
Zs. Oberritter
,
B. Horváth
,
Z. Szilvássy
, and
D. Reglődi

Abstract  

Pituitary adenylate cyclase activating polypeptide (PACAP) is a widely distributed neuropeptide that has two molecular forms with 38 and 27 amino acid residues. The aim of the present study was to develop a new, highly specific PACAP-27 assay to investigate the quantitative distribution of PACAP-27 in the central nervous system of various vertebrate species applying the same technical and experimental conditions. Our results show that the antiserum used turned to be PACAP-27 specific. The average ID50 value was 51.5±3.6 fmol/ml and the detection limit was 2 fmol/ml. PACAP-27 immunoreactivity was present in the examined brain areas, with highest concentration in the rat diencephalon and telencephalon. Swine and pigeon brain also contained significant amount of PACAP-27. Our results confirm the previously described data showing that PACAP-38 is the dominant form of PACAP in vertebrates, since PACAP-38 levels exceeded those of PACAP-27 in all examined brain areas. Furthermore, our study describes for the first time, the comparative quantitative distribution of PACAP-27 and-38 in the swine and pigeon brain.

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Acta Physiologica Hungarica
Authors:
K. Csanaky
,
D. Reglődi
,
E. Bánki
,
I. Tarcai
,
L. Márk
,
Zs Helyes
,
T. Ertl
,
J. Gyarmati
,
K. Horváth
,
L. Sántik
, and
Andrea Tamás

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with special importance in reproductive and developmental processes. PACAP is found in two bioactive forms: PACAP27 and PACAP38. Recently, we have described that PACAP38 is present in high levels in the milk of human and ruminant animals. Breastfeeding is of utmost importance in proper nutrition of the newborn, but artificial nursing with infant formulas is necessary when breastfeeding is not available. Composition of the breast milk varies during the whole period of nursing and it shows differences at the beginning (foremilk) and the end of an actual suckling (hindmilk). The aim of this study was to investigate PACAP38-like immunoreactivity (PACAP38-LI) in different milk and infant formula samples by radioimmunoassay and to prove the presence of PACAP38 in the infant formula by mass spectrometry. We found similar PACAP38-LI in human mature foremilk and hindmilk samples, in the fresh and pasteurized cow milk and also in formulas. However, we found significantly higher PACAP38-LI in the hypoantigenic formula undergoing extensive hydrolysis compared to the non-hypoantigenic ones. Our results suggest that PACAP38 is relatively stable in the milk and it can withstand the manufacturing processes.

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Physiology International
Authors:
M. Fekete
,
V. Fazekas-Pongor
,
P. Balazs
,
S. Tarantini
,
G. Szollosi
,
J. Pako
,
A.N. Nemeth
, and
J.T. Varga

Abstract

Background

Pathological alterations in nutritional status may develop in Chronic Obstructive Pulmonary Disease (COPD) patients through production of inflammatory cytokines and inadequate diet.

Objective

The aim of our study was to determine the correlation between nutritional status and quality of life of COPD patients.

Methods

We evaluated the nutritional status of COPD patients of Hungarian National Koranyi Institute for Pulmonology using the Malnutrition Universal Screening Tool (MUST) and bioelectrical impedance analysis (BIA) between January 1 and June 1, 2019. Lung function, physical fitness, and respiratory muscle strength were included in the assessment.

Results

Fifty patients (mean age was 66.3 ± 9.6 years) participated in our study. Mean body mass index (BMI) was 26.2 ± 6.1 kg/m2 and mean fat-free mass index (FFMI) was 16.8 ± 2.4 kg/m2. Overweight patients had better lung function values (FEV1ref%: 46.3 ± 15.2) than normal (FEV1ref%: 45.1 ± 20.9) and underweight patients (FEV1ref%: 43.8 ± 16.0). The Modified Medical Research Council Dyspnea Scale (mMRC) was significantly associated with various parameters; strongest correlation was found with FFMI (r = −0.537, P < 0.001), skeletal muscle mass index (SMMI) (r = −0.530, P < 0.001), and 6-minute walking distance (6MWD) (r = −0.481, P < 0.001).

Conclusions

Our results indicate that malnourished COPD patients may have reduced lung function and lower quality of life compared to normal weight patients. Thus, our findings suggest that nutritional therapy be included in the treatment of COPD patients combined with nutritional risk screening and BIA during the follow-up.

Open access
Acta Veterinaria Hungarica
Authors:
L. Kóbori
,
G. Dallos
,
Anette S. H. Gouw
,
Tamás Németh
,
B. Nemes
,
I. Fehérvári
,
A. M. Tegzess
,
M. J. H. Slooff
,
K. P. De Jong
, and
F. Perner

Vascular complications in liver transplantation are a major cause of graft failure and mortality. The aim of the study was to create autologous vascular graft without risk of rejection. Posterior rectus fascia sheath lined with peritoneum was used for iliac artery replacement in seven mongrel dogs. The patency was followed by palpation and Doppler ultrasound. The grafts were removed after one month. Five grafts remained patent. The Doppler showed good, relatively increased flow (median flow rate: 383 cm/sec) after one month in all of the cases. Slight increase in diameter was present in all cases. By microscopy the five patent grafts showed viable morphology, fibroblasts, smooth muscle cells and thin fibrin layer in the wall. The grafts were lined partially with a neoendothelial monolayer and a thin fibrin layer. In conclusion, this graft presents an acceptable patency rate and low thrombogenicity, and could be useful in transplantation. Further investigations are needed to study the effect of immunosuppression and rejection on long-term morphology and patency of the grafts.

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Orvosi Hetilap
Authors:
Attila Nemes
,
Marcel L. Geleijnse
,
Osama I. I. Soliman
,
Ashraf M. Anwar
,
Wim B. Vletter
,
Jackie S. McGhie
,
Miklós Csanády
,
Tamás Forster
, and
Folkert J. Ten Cate

A hypertrophiás cardiomyopathia egy relatíve gyakori öröklődő betegség, amely sajátos kardiális morfológiai és funkcionális eltérésekkel jár együtt. Az echokardiográfia a cardiomyopathiás betegek noninvazív vizsgálatának egyszerű, könnyen kivitelezhető és megtanulható módszereként szolgál. Ennek az összefoglaló jellegű közleménynek a célja az egyik legújabb echokardiográfiás fejlesztés, a real-time háromdimenziós echokardiográfia lehetséges diagnosztikus szerepének bemutatása hypertrophiás cardiomyopathiában.

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Orvosi Hetilap
Authors:
Attila Nemes
,
Marcel L. Geleijnse
,
Osama I.I. Soliman
,
Ashraf M. Anwar
,
Johan G. Bosch
,
Boudewijn J. Krenning
,
Sing-Chien Yap
,
Wim B. Vletter
,
Jackie S. McGhie
,
Tamás Forster
,
Miklós Csanády
, and
Folkert J. ten Cate

A kardiológiai betegek ellátásában a noninvazív vizsgáló módszereknek alapvető jelentőségük van. Elméletileg a szív akkor vizsgálható tökéletesen, ha természetének megfelelően három dimenzióban rögzítjük a szívciklus szerint. A második generációs, immár real-time (vagyis valós idejű) háromdimenziós echokardiográfok elméletileg optimális lehetőséget nyújtanak a cardialis struktúrák háromdimenziós elemzésére. Real-time 3-dimenziós echokardiográfia során pontosan mérhetők a kamrai és pitvari térfogatok, valamint a kamrai izomtömeg. A billentyűk és a congenitalis abnormalitások ‘en-face’ vizsgálhatók. Használhatóságát terheléses protokollok alkalmazása mellett igazolták. A jelen összefoglaló közlemény célja a módszer bemutatása, lehetséges előnyeinek tisztázása a jelenleg még fennálló technológiai korlátok bemutatásával együtt.

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Physiology International
Authors:
V. Fazekas-Pongor
,
M. Fekete
,
P. Balazs
,
D. Árva
,
M. Pénzes
,
S. Tarantini
,
R. Urbán
, and
J.T. Varga
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Acta Botanica Hungarica
Authors:
J. Csiky
,
L. Balogh
,
I. Dancza
,
F. Gyulai
,
G. Jakab
,
G. Király
,
É. Lehoczky
,
A. Mesterházy
,
P. Pósa
, and
T. Wirth

As part of the PADAPT project, the authors compiled the invasion biological database of the alien vascular flora of Hungary, which contains the nativeness, residence time, introduc- tion mode and invasion status of 878 alien or cryptogenic taxa. In the absence of adequate evidence, the classification of some species was only possible into uncertain, transitional cat- egories. The definitions of most categories are compatible with several international termi- nologies, but are primarily based on Central European traditions. Of the 560 taxa that have already been naturalised in Hungary, 85 are invasive, and 22 of them are transformer alien vascular plants. Only 5 of these transformers are included in the European list of Invasive Alien Species of Union concern (Ailanthus altissima, Asclepias syriaca, Elodea nuttallii, Heracleum mantegazzianum and H. sosnowskyi), which require uniform preventive interventions and treatments throughout the continent, while the rest of transformers in Hungary (e.g., Robinia pseudoacacia, Fallopia × bohemica and Solidago gigantea) draw attention to the unique, local and/ or regional invasion biological situation of the Pannonian Basin and Central Europe.

Open access
Acta Botanica Hungarica
Authors:
K. Török
,
K. Szilágyi
,
K. Halász
,
V. Zsigmond
,
G. Kósa
,
T. Rédei
,
E. Peti
,
J. Schellenberger
,
Z. Tóth
, and
K. Szitár

Seed bank collections have multiple benefits: store genetic material for conservation and research, and their data can also provide valuable scientific information. The Pannon Seed Bank was established during an EU LIFE+ project between 2010 and 2014 with the target to collect and store seeds of approx. 50% of the wild native vascular flora of the Pannonian Biogeographic Region, seed accessions of at least 800 storable species. This task was fully achieved by the end of the project, as altogether 1,853 seed accessions of 910 species are stored. The aim of the present paper is to provide access to the collection data and metadata of the Pannon Seed Bank as it was completed by the end of the project. The collection campaign involved about 40 experts and covered the whole country. Collection and storing applied standard methodology, based on the ENSCONET project. The collection data published in this paper can be used manifold. Geographical data on species occurrences are major input for nature conservation and research. Seed collection date is valuable for ecological studies of phytophagous insects, frugivorous birds and mammals, etc. The database can be partner to international databases (like GBIF) or research infrastructures (e.g. LifeWatch). Hopefully, this data paper will contribute to further motivate the development of native seed collections and their use for conservation and research in Hungary.

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Acta Botanica Hungarica
Authors:
R. Kiss
,
J. Sonkoly
,
P. Török
,
B. Tóthmérész
,
B. Deák
,
K. Tóth
,
K. Lukács
,
L. Godó
,
A. Kelemen
,
T. Miglécz
,
Sz. Radócz
,
E. Tóth
,
N. Balogh
, and
O. Valkó

Seeds ensure the survival and dispersal of the majority of vascular plant species. Seeds require species-specific germination conditions and display very different germination capacities using different germination methods. Despite the importance of plant generative reproduction, little is known about the germination capacity of the seeds of the Pannonian flora, particularly under field conditions. Our aim was to reduce this knowledge gap by providing original data on the germination capacity of 75 herbaceous species. We reported the germination capacity of 8 species for the first time. We also highlighted the year-to-year differences in the germination capacity of 11 species which could be highly variable between years. The data regarding the germination capacity of target species, as well as weeds and invasive species, can be informative for nature conservation and restoration projects. Our findings support the composition of proper seed mixtures for ecological restoration and also highlight the importance of testing seed germination capacity before sowing.

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