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Acta Chromatographica
Authors:
Bingying Hu
,
Yingying Sun
,
Min Wang
,
Zhisheng He
,
Shanshan Chen
,
Dake Qi
,
Zhen Ge
,
Lingling Fan
,
Jingfang Chen
, and
Yang Wei

Abstract

A reliable LC-MS/MS method for the determination of five bioactive constituents (bilobalide, BLL; ginkgolide A, GLA; ginkgolide B, GLB; ginkgolide C, GLC; rutin) of Ginkgo biloba leaf extracts (GBE) in rat plasma was established, fully validated and applied to an intragastric pharmacokinetic study of a preparation of GBE in rat. Samples were extracted with ethyl acetate. C18 column was selected as analytical column in this method. Mobile phase was water with 0.01% formic acid and acetonitrile. Quantification was performed in negative multiple-reaction monitoring mode. Matrix instability of terpene lactones was noticed and hydrochloric acid was used as a stabilizer. This method showed good precision and accuracy, recovery was reproducible and matrix effect was negligible. Among four terpene lactones, BLL had the highest exposure and the shortest terminal half-life, GLA and GLB had lower exposure and longer terminal half-life, the exposure of GLC was lowest and its terminal half-life was the maximum, and all of them showed rapid absorption. This study provides a reference for determination of terpene lactones and flavonol glycoside prototypes in GBE and offers pharmacokinetic data of flavonol glycoside prototype in GBE.

Open access
Journal of Behavioral Addictions
Authors:
Wei Hong
,
Peipeng Liang
,
Yu Pan
,
Jia Jin
,
Lijuan Luo
,
Ying Li
,
Chen Jin
,
Wanwan Lü
,
Min Wang
,
Yan Liu
,
Hui Chen
,
Huixing Gou
,
Wei Wei
,
Zhanyu Ma
,
Ran Tao
,
Rujing Zha
, and
Xiaochu Zhang

Abstract

Background and aims

Impaired value-based decision-making is a feature of substance and behavioral addictions. Loss aversion is a core of value-based decision-making and its alteration plays an important role in addiction. However, few studies explored it in internet gaming disorder patients (IGD).

Methods

In this study, IGD patients (PIGD) and healthy controls (Con-PIGD) performed the Iowa gambling task (IGT), under functional magnetic resonance imaging (fMRI). We investigated group differences in loss aversion, brain functional networks of node-centric functional connectivity (nFC) and the overlapping community features of edge-centric functional connectivity (eFC) in IGT.

Results

PIGD performed worse with lower average net score in IGT. The computational model results showed that PIGD significantly reduced loss aversion. There was no group difference in nFC. However, there were significant group differences in the overlapping community features of eFC1. Furthermore, in Con-PIGD, loss aversion was positively correlated with the edge community profile similarity of the edge2 between left IFG and right hippocampus at right caudate. This relationship was suppressed by response consistency3 in PIGD. In addition, reduced loss aversion was negatively correlated with the promoted bottom-to-up neuromodulation from the right hippocampus to the left IFG in PIGD.

Discussion and conclusions

The reduced loss aversion in value-based decision making and their related edge-centric functional connectivity support that the IGD showed the same value-based decision-making deficit as the substance use and other behavioral addictive disorders. These findings may have important significance for understanding the definition and mechanism of IGD in the future.

Open access

Abstract  

The mechanism of solvent extraction of uranium(VI) from highly concentrated chloride solution with a quaternary ammonium salt, benzyloctadecyldimethylammonium chloride (BODMAC, R4NCl), dissolved in chloroform was studied. The compositions of the extracted species were R4N.UO2Cl3 and (R4N)2 .UO2Cl4. The extraction process is exothermic (ΔH° = -8.42±0.54 KJ/mol). Kex 1 and Kex 2 are calculated to be (3.62±0.55).10-2 and (1.06±0.17).103, respectively. In the extraction process, a W/O uranium(VI) rich emulsion solution has been formed between the organic and aqueous phases, its volume increased with the increase of BODMAC in the system. The influences of temperature, NaCl, MgCl2 and MgSO4 concentrations on the extraction equilibrium were also studied.

Restricted access
Journal of Radioanalytical and Nuclear Chemistry
Authors:
Ye Yu-xing
,
Hu Jin-xin
,
Huang Zi-lin
,
Shi Wei-qun
,
Wu Guang-min
,
Tang Hong-bin
,
Zhu Wen-bin
,
Wang Xiao-rong
,
Zhao Hu-gen
,
Dong Yu
,
Sheng Dong
,
Luo Fang-xiang
, and
Zhao Yan-ju

Abstract  

The partitioning of actinides from simulated high level liquid waste (HLLW) originated from the Purex process has been studied using a mixture of dihexyl N,N-diethylcarbamoylmethyl-phosphonate (DHDECMP) and tributylphosphonate (TBP) in kerosene (OK). The distribution ratios of actinides were investigated as a function of a number of parameters such as the concentration of nitric acid, salting-out reagent, Gd(III) in the aqueous phase, extractant in the organic phase, and temperature. The extraction complexes, extraction reaction constant k, and thermodynamic parameters H, G and S were determined. The extraction of actinides from simulated HLLW by DHDECMP-TBP/OK has been carried out using a miniature countercurrent centrifugal contactor. The results show that the removal efficiency of actinides is greater than 99.9%. A conceptual flowsheet for the removal of actinides from HLLW is proposed.

Restricted access