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The subject of the present study is the monitoring of the hardwood groves at the Martonvásár Manor Park with the involvement of 20 earlier (recorded in 1980–1981) and 20 current (recorded in 2011–2012) phytocoenological relevés. The manor park was created in the first half of the 19th century. Since then the woods along the St László stream have developed into species-rich and semi-natural forests, which can be identified as related to the oak-ash-elm groves (Scillo vindobonensis-Ulmetum) of the Zámoly Basin and the Csepel Island. The results of the current monitoring repeated 30 years after the first survey show momentous changes in forest dynamics such as the ageing-related opening of the upper canopy and an intense closure of the lower canopy and shrub layer. The ratio of the invasive species doubled. Present findings may provide additional information for long-term forest ecology research, however, results could be considered as changes of a semi-natural hardwood forest with minimal human impact.

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Enzyme-linked immunosorbent assays (ELISAs) are widely used to determine gluten contamination in gluten-free and low gluten food samples. ELISA assays developed using monoclonal antibodies against known toxic peptides have an advantage in the identification of toxic prolamin content in protein extracts of different food samples, as well as raw materials. R5 and G12 monoclonal antibodies specific for two known toxic peptides used in commercially available gluten ELISA assays were applied to test toxic peptide contents in wheat relatives and wild wheat species with different genome composition and complexity. Although the R5 peptide content showed some correlation with ploidy levels in Triticum species, there was a high variance among Aegilops species. Some of the analysed diploid Aegilops species showed extremely high R5 peptide contents. Based on the bioinformatics analyses, the R5 peptide was present in most of the sulphur rich prolamins in all the analysed species, whereas the G12 epitope was exclusively present in alpha gliadins. High variation was detected in the position and frequency of epitopes in sequences originating from the same species, thus highlighting the importance of genotypic variation within species. Identification of new prolamin alleles of wheat relatives and wild wheat species is of great importance in order to find germplasm for special end-use quality purposes as well as development of food with reduced toxicity.

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Interventional Medicine and Applied Science
Authors:
Sz. Szilágyi
,
Béla Merkely
,
L. Molnár
,
E. Zima
,
I. Osztheimer
,
E. M. Végh
, and
L. Gellér

Abstract

Objective

We describe a method to stabilize CS lead position using stent implantation in a CS side branch to anchor the electrode to the wall of the vein, in cases of intraoperative or postoperative lead dislocation, unstable lead position and phrenic nerve stimulation (PNS).

Methods

403 patients were treated with stenting. After finding the desired lead position bare metal coronary stent was introduced via another guide wire, but in the same CS sheath. The stent was deposited 5–35 mm proximal to the tip of the electrode with a pressure of 6 to 14 atmospheres.

Results

Mechanical damage of the CS side branch or pericardial effusion was not observed. During follow-up (median 39, 23–48, max. 82 months) re-operation was necessary in only two patients because of high pacing threshold, while repositioning with ablation catheter was performed in 7 cases because of PNS. Impedance measurements did not suggest lead insulation failure. Transvenous extraction of stented CS leads was successful after 3, 18 and 49 months, while 4 leads were extracted easily during heart transplantation.

Conclusion

Stent implantation to stabilize CS lead position seems to be effective and safe for the prevention and treatment of CS lead dislocation in special cases.

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Progressive loss of muscle mass and strength is a physiological consequence of aging, and without interventions, it usually deteriorates into sarcopenia. In this study, the hypothesis that combined special nutritional–physiotherapeutical intervention to prevent or reverse this biological deterioration in elderly people was tested. The effects of the regular resistance muscle training (PT, n = 17) alone and the combined exercise + special nutrition therapy containing whey protein and vitamin D (PT + NT, n = 17) were monitored for 3 months in 34 elderly patients (12 men and 22 women; mean age: 66.47 years) randomly distributed into two groups at a long-term care facility. Physical exercise alone did not result in significant improvement in skeletal muscle mass or strength, whereas combined intervention significantly increased the muscle strength (22.51 ± 2.35 vs. 24.54 ± 2.65, x ¯  ± SEM, kg, p = 0.027). When therapeutic responses to the intervention were compared, a significant advantage of PT + NT over PT was found. The same trend was found when the non-significant post-therapeutic alterations (χ2 test) of the distribution of normal vs. pre-sarcopenic + sarcopenic conditions within the two groups were compared. Combined intervention (PT + NT) is necessary for the efficient protection of the musculature in the high-risk elderly patients.

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Journal of Radioanalytical and Nuclear Chemistry
Authors:
Em. Cincu
,
I. Manea
,
V. Manu
,
D. Barbos
,
O. Sima
,
I. Gustavsson
,
P. Vermaercke
,
N. Vajda
,
Zs. Molnar
, and
H. Polkowska-Motrenko

Abstract  

Samples of high alloy Stainless Steel SS 1 were analyzed by instrumental neutron activation analysis (INAA) at 5 research institutes in 4 European countries within the frame of an Inter-Laboratory Comparison (ILC) exercise aiming at checking if the results were independent of the standardization methods, and if INAA was accurate enough to contribute to certification. The mean element concentration values yielded by INAA were also compared with mean values obtained by atomic emission spectroscopy techniques at other laboratories that took part in the International Proficiency Testing organized by KIMAB Institute of Sweden, producer of the SS 1. The performances of the nuclear and atomic techniques were compared in terms of the z-score values calculated for 11 element concentrations evaluated by the two analytical ways. Finally, consideration is given to the ways in which highest accuracy and precision can be ensured for certifying stainless steels as CRMs.

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Physiology International
Authors:
J Fodor
,
A Gomba-Tóth
,
T Oláh
,
E Zádor
,
Zs Cs Tóth
,
I Ioannis
,
B Molnár
,
I Kovács
, and
L Csernoch

Atherosclerosis is a disease caused by a build-up of fatty plaques and cholesterol in the arteries. The lumen of the vessels is obliterated resulting in restricted blood supply to tissues. In ischemic conditions, the cytosolic Ca2+ level of skeletal muscle may increase, indicating the alteration of Ca2+ removal mechanisms. Ca2+ is transported from cytosol into the sarcoplasmic reticulum by Ca2+ ATPase (SERCA), with its 1a isoform expressed in adult, while its 1b isoform in neonatal and regenerating fast-twitch skeletal muscle. To investigate the role of these isoforms in ischemic skeletal muscle, biopsies from musculus biceps femoris of patients who underwent amputation due to atherosclerosis were examined. Samples were removed from the visibly healthy and hypoxia-affected tissue. Significantly increased SERCA1a expression was detected under the ischemic conditions (246 ± 69%; p < 0.05) compared with the healthy tissue. Furthermore, the ratio of SERCA1a-positive fibers was slightly increased (46 ± 4% in healthy tissue and 60 ± 5% in ischemic tissue; p > 0.05), whereas SERCA2a did not change. In addition, in primary cultures derived from hypoxia-affected tissue, the diameter and fusion index of myotubes were significantly increased (30 ± 1.6 µm vs. 41 ± 2.4 µm and 31 ± 4% vs. 45 ± 3%; p < 0.05). We propose that the increased SERCA1a expression indicates the existence and location of compensating mechanisms in ischemic muscle.

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Abstract

In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for forensic and pathologic examination. However, classical dissection remains dominant in everyday practice. Lack of quantifiable data on the coronary system has become a disadvantageous attribute of traditional autopsy. Therefore, post mortem MSCT angiography was performed in 80 ex corpo hearts with the aim of improving the accuracy and quantitative documentation of pathologic and forensic diagnoses of coronary artery disease (CAD). Hearts were perfused by introducing a new oily or synthetic resin, or using both contrast materials successively. Then the perfused organs were processed for imaging. Detailed angiographic analysis enabled us to localize, map and quantify coronary calcifications, stenoses, and to characterize the types of atherosclerotic plaques. Significant early or late complications of widely used percutaneous coronary interventions (PCI) and coronary bypass surgery (CABS) could be revealed using CT analysis. Furthermore, by using our oily contrast material and CT imaging, we could identify and visualize the clinically important small caliber nodal arteries (diameter 0.4–2.0 mm). The present work suggests that post mortem CT angiography and post-processing of the data may improve the quality of pathologic and forensic diagnosis. Our collection of coronary casts including digital data are available for further analysis.

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Acta Veterinaria Hungarica
Authors:
I. Biksi
,
Márta Lőrincz
,
Beáta Molnár
,
T. Kecskés
,
N. Takács
,
Darja Mirt
,
A. Cizek
,
Z. Pejsak
,
G. Martineau
,
J. Sevin
, and
O. Szenci

The aim of this study was to obtain prevalence estimates about the most important enteropathogenic bacteria: Lawsonia intracellularis, Brachyspira hyodysenteriae, Brachyspira pilosicoli, Salmonella enterica and Clostridium perfringens A and C in Hungarian farrow-to-finish pig herds. A total of 31 herds were selected, from where six pooled faecal samples, each containing three individual rectal faecal samples were collected from fattening pigs of 5–6 months of age. All 186 samples were examined by polymerase chain reaction (PCR) for the presence of the pathogens mentioned above. Lawsonia intracellularis was found in 29 herds (93.55%) and in 108 samples (58.06%); B. hyodysenteriae in 14 herds (45.16%) and in 23 samples (12.37%); B. pilosicoli in 19 herds (61.29%) and in 53 samples (28.49%); S. enterica in 17 herds (54.83%) and in 40 samples (21.50%). We detected the presence of C. perfringens A in 19 herds (61.29%) and in 46 samples (24.73%), while C. perfringens C was found in 8 herds (25.81%) and in 11 samples (5.91%). All examined herds were infected with one or more of these agents. Herds with diarrhoea in the mid-to late finishing phase had almost 10 times higher prevalence of B. hyodysenteriae than herds without such a history.

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Agrokémia és Talajtan
Authors:
A. Horel
,
Zs. Bakacsi
,
M. Dencső
,
Cs. Farkas
,
Gy. Gelybó
,
I. Kása
,
E. Tóth
,
S. Molnár
, and
S. Koós

A vizsgálat 42 órája alatt (2016. február 3–4.) és az előtte lévő öt hónapban összesen négy nagyobb mennyiségű csapadékesemény történt a Csorsza-patak vízgyűjtő területén. A vizsgált esőzés időszakában 21,6 mm csapadékmennyiség hullott összesen a vízgyűjtő területére 5 órás intervallumban. A csapadékesemény első órájában a patak zavarosság értéke majdnem megduplázódott, viszont így is viszonylag alacsony szinten maradt a későbbiekben mért értékekhez viszonyítva. Az esőzés kezdetét követő 7. órában emelkedett meg jelentősen a zavarosság mértéke, több mint 14-szeresére, a 13–14. órában pedig 34-szeresére nőtt a vizsgálat előtti naphoz viszonyítva. A Csorsza-patak zavarosságának nagysága nem sokkal a tetőzést követően nagy mértékben lecsökkent, 13 órával később pedig hasonló értékeket mutatott, mint a vizsgálat előtti esőzés nélküli időszakban.

A nagyobb esőzések alkalmával az alacsonyabb területeken fekvő, minimális lejtésű szántó esetében telítettséghez közeli talajnedvesség-tartalom volt megfigyelhető, míg a legkisebb talajnedvesség-tartalom ingadozás az esőzést követően a gyepes és az erdős területekre volt jellemző.

A jelen vizsgálatban összegyűjtött adatok alapján a Csorsza-patakból a Balatonba bekerülő talajhordalék mennyisége a téli időszakban, az erozív esőzések gyakoriságának ismeretében könnyebben és pontosabban becsülhető. Annak érdekében, hogy az éves átlag lebegtetett hordalék mennyiségének a becslését pontosabban el tudjuk végezni, több időszakos mérésre volna szükség.

Munkánkat az OTKA K—101065 projekt, az OTKA PD—116157 és OTKA PD—116084 kutatási projekt, valamint a Bolyai János Kutatási Ösztöndíj támogatta. Külön köszönet Mózes Mariann és Bányász Ágnes részére a laboratóriumi vizsgálatokban nyújtott segítségükért, valamint Szegvári Győző és kollégáinak a zánkai vízminták gyűjtésében való hatalmas segítségükért.

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Journal of Radioanalytical and Nuclear Chemistry
Authors:
G. Molnár
,
T. Belgya
,
L. Dabolczi
,
B. Fazekas
,
Zs. Révay
,
Á. Veres
,
I. Bikit
,
Z. Kiss
, and
J. Östör

Abstract  

Prompt gamma-activation analysis (PGAA) is an important complementary technique to conventional instrumental activation analysis that can be successfully used in a number of cases when INAA is not applicable. Therefore, a PGAA facility has been constructed at the recently refurbished and upgraded Budapest Research Reactor. It occupies the end position of a new curved themal guide of 30 m length and 2.5×10 cm2 cross section which provides a clean beam of low energy neutrons. The sophisticated HPGe-BGO -ray spectrometer system can be operated in Compton-suppression and pair-spectrometer modes simultaneously. The octal splitting of the main BGO improves efficient pair mode operation when coincidences between pairs of opposite segments and the HPGe detector are required separately. Gamma-gamma coincidence measurements will also be possible when the new multiparameter data acquisition system is completed. One of the main tasks at the new facility will be the accumulation of new spectroscopic data for detector calibration and standardisation, as well as for the construction of a more accurate prompt -ray library for the chemical elements. Various applications are planned, such as the determination of hydrogen in fullerenes and of toxic trace elements in environmental samples.

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